Literature DB >> 3431543

Dexamethasone-induced phosphorylation of high mobility group nonhistone proteins of aging rats.

S Prasad1, M K Thakur.   

Abstract

Phosphorylation of high mobility group (HMG) proteins and its modulation by dexamethasone were examined in vitro by incubating liver slices of young (15-) and old (138-week) male rats with (32P) orthophosphate. HMG proteins were extracted and analyzed by acid-urea polyacrylamide gel electrophoresis. Phosphorylation of HMG proteins, particularly of HMG2, 14 and 17 decreases drastically in old rats. Dexamethasone stimulates the phosphorylation of total HMG proteins in both ages. Individual HMG proteins vary in the extent of 32P incorporation. Such differential phosphorylation of HMG proteins and its modulation by dexamethasone may affect chromatin organization and gene expression during aging.

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Year:  1987        PMID： 3431543     DOI： 10.1007/BF00444679

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  19 in total

1.  An improved large scale fractionation of high mobility group non-histone chromatin proteins.

Authors:  G H Goodwin; R H Nicolas; E W Johns
Journal:  Biochim Biophys Acta       Date:  1975-10-20

2.  Nonhistone proteins HMG1 and HMG2 unwind DNA double helix.

Authors:  K Javaherian; M Sadeghi; L F Liu
Journal:  Nucleic Acids Res       Date:  1979-08-10       Impact factor: 16.971

3.  Phosphorlyation of H1 and H5 histones by cyclic AMP-dependent protein kinase reduces DNA binding.

Authors:  T M Fasy; A Inoue; E M Johnson; V G Allfrey
Journal:  Biochim Biophys Acta       Date:  1979-09-27

4.  The isolation of the high mobility group non-histone chromosomal protein HMG 14.

Authors:  G H Goodwin; A Rabbani; P H Nicolas; E W Johns
Journal:  FEBS Lett       Date:  1977-08-15       Impact factor: 4.124

5.  Control of aerobic glycolysis in guinea-pig cerebral cortex slices.

Authors:  G Takagaki
Journal:  J Neurochem       Date:  1972-07       Impact factor: 5.372

6.  Differential phosphorylation of nuclear nonhistone high mobility group proteins HMG 14 and HMG 17 during the cell cycle.

Authors:  J S Bhorjee
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

7.  Interaction of HMG 14 and 17 with actively transcribed genes.

Authors:  S Weisbrod; M Groudine; H Weintraub
Journal:  Cell       Date:  1980-01       Impact factor: 41.582

8.  The effects of dexamethasone on histone phosphorylation in L cells.

Authors:  D A Prentice; S E Taylor; M Z Newmark; P A Kitos
Journal:  Biochem Biophys Res Commun       Date:  1978-11-29       Impact factor: 3.575

9.  Phosphorylation of high-mobility-group proteins by the calcium-phospholipid-dependent protein kinase and the cyclic AMP-dependent protein kinase.

Authors:  C Ramachandran; P Yau; E M Bradbury; G Shyamala; H Yasuda; D A Walsh
Journal:  J Biol Chem       Date:  1984-11-10       Impact factor: 5.157

10.  HMG (high-mobility-group)-14/17-like proteins in calf thyroid. Thyrotropin-dependent phosphorylation and comparison with calf thymus proteins.

Authors:  E Cooper; S W Spaulding
Journal:  Biochem J       Date:  1983-12-01       Impact factor: 3.857
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  1 in total

1.  Analysis of age-associated alteration in the synthesis of HMG nonhistone proteins of the rat liver.

Authors:  M K Thakur; S Prasad
Journal:  Mol Biol Rep       Date:  1991-02       Impact factor: 2.316
  1 in total

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