Rapid antigen detection alone may not be sufficient for early diagnosis and/or mass screening of COVID-19.

Currently, COVID-19 pandemic is still severe, and the major challenge in the fight against this pandemic is how to early find pre-symptomatic and asymptomatic individuals and to eliminate silent transmission. Rapid antigen detection alone may not be sufficient for early diagnosis and/or mass screening of COVID-19, and direct probe-based RT-LAMP assay or other nucleic acid amplification (NAA)-based POCT strategies should be recommended to use alone or together with rapid antigen test in mass screening or community-based testing of SARS-CoV-2 This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.