Literature DB >> 34311790

The use and effects of synthetic cannabinoid receptor agonists by New South Wales cannabis treatment clients.

Melissa A Jackson1, Amanda L Brown2, Jennifer Johnston3, Richard Clancy4, Iain McGregor5, Raimondo Bruno6, Nick Lintzeris7, Mark Montebello8, Jennifer Luksza9, Jenny Bowman10, Nghi Phung11, Dave Allsop5, Adrian J Dunlop2.   

Abstract

INTRODUCTION: Despite decreasing consumption by general populations, use of synthetic cannabinoid receptor agonists (SCRAs) persists in some marginalised groups, including those who use other substances. This article explores SCRA consumption in an Australian cannabis treatment sample, comparing those who report ever using SCRAs with those who have never used SCRAs.
METHODS: A questionnaire orally administered in person to a convenience sample of 154 cannabis treatment service clients from New South Wales, Australia (71% male, median age 35) collected information regarding cannabis and SCRA use including motivations, effects and health-related consequences of use, demographics, other substance use and overall health. Demographic profiles and between-group differences were explored. McNemar tests compared effects of SCRA and cannabis. Logistic regression analysis determined predictors of SCRA use.
RESULTS: Half (53%) reported lifetime SCRA use; 20% reported previous-month use. The SCRA + cannabis group displayed greater polysubstance use and psychological distress. Reduced dependence on cannabis but higher levels of other substance use may predict SCRA use. Although curiosity motivated initial SCRA consumption, perceived psychoactive strength drove continued use. SCRAs appear to induce more negative side-effects than cannabis. Of the SCRA + cannabis group, 27% sought medical assistance for SCRA use. Most (90%) preferred cannabis to SCRAs, citing superior safety, effects and consistency of cannabis.
CONCLUSIONS: Among clients seeking treatment for cannabis use, SCRA use was relatively common, although not a preferred substance. Hazardous substance use and poor mental health characterised SCRA consumers, highlighting the need for continued monitoring by researchers and treatment providers of SCRA consumption in populations who use substances.
© 2021. The Author(s).

Entities:  

Keywords:  Cannabis; Marijuana; Substance use disorder; Synthetic cannabinoid receptor agonist; Synthetic cannabinoids; Treatment

Year:  2021        PMID: 34311790     DOI: 10.1186/s42238-021-00091-z

Source DB:  PubMed          Journal:  J Cannabis Res        ISSN: 2522-5782


  23 in total

Review 1.  Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ(9)-THC: mechanism underlying greater toxicity?

Authors:  William E Fantegrossi; Jeffery H Moran; Anna Radominska-Pandya; Paul L Prather
Journal:  Life Sci       Date:  2013-09-29       Impact factor: 5.037

2.  A Polydrug and Psychosocial Profile of Synthetic Cannabinoid Use in a New York City Community Sample, 2016-2017.

Authors:  Adriana Joseph; Helen-Maria Lekas; Marc Manseau; Crystal Lewis
Journal:  Subst Use Misuse       Date:  2018-12-07       Impact factor: 2.164

3.  The impact of Australian legislative changes on synthetic cannabinoid exposures reported to the New South Wales Poisons Information Centre.

Authors:  Rose Cairns; Jared A Brown; Naren Gunja; Nicholas A Buckley
Journal:  Int J Drug Policy       Date:  2017-03-23

4.  Synthetic cannabinoid use in an acute psychiatric inpatient unit.

Authors:  Richard Vincent Clancy; Robert Charles Hodgson; Arvind Kendurkar; Margarett Ann Terry; Lawrence Dadd; Donna Maria Clancy; Karen Ryan; Maria Hatzistylis; Benjamin Graham Tinman
Journal:  Int J Ment Health Nurs       Date:  2017-05-15       Impact factor: 3.503

5.  A survey of synthetic cannabinoid consumption by current cannabis users.

Authors:  Erik W Gunderson; Heather M Haughey; Nassima Ait-Daoud; Amruta S Joshi; Carl L Hart
Journal:  Subst Abus       Date:  2014       Impact factor: 3.716

6.  From niche to stigma-Headshops to prison: Exploring the rise and fall of synthetic cannabinoid use among young adults.

Authors:  Shane Blackman; Rick Bradley
Journal:  Int J Drug Policy       Date:  2016-11-25

7.  Synthetic cannabinoid use among patients in residential substance use disorder treatment: prevalence, motives, and correlates.

Authors:  Erin E Bonar; Lisham Ashrafioun; Mark A Ilgen
Journal:  Drug Alcohol Depend       Date:  2014-07-17       Impact factor: 4.492

Review 8.  Synthetic Cannabinoids-Further Evidence Supporting the Relationship Between Cannabinoids and Psychosis.

Authors:  Liana Fattore
Journal:  Biol Psychiatry       Date:  2016-02-04       Impact factor: 13.382

9.  Patterns of synthetic cannabinoid use in Australia.

Authors:  Monica J Barratt; Vince Cakic; Simon Lenton
Journal:  Drug Alcohol Rev       Date:  2012-10-09

10.  Beyond THC: The New Generation of Cannabinoid Designer Drugs.

Authors:  Liana Fattore; Walter Fratta
Journal:  Front Behav Neurosci       Date:  2011-09-21       Impact factor: 3.558

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