Håkan Ashina1,2, Haidar Muhsen Al-Khazali1, Afrim Iljazi1, Sait Ashina3,4,5,6, Faisal Mohammad Amin1, Richard B Lipton7,8, Henrik Winther Schytz9. 1. Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Valdemar Hansen Vej 5, DK-2600, Glostrup, Denmark. 2. Department of Neurorehabilitation and Traumatic Brain Injury, Rigshospitalet, Copenhagen, Denmark. 3. Comprehensive Headache Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 4. Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 5. Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 6. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 7. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. 8. Montefiore Headache Center, Bronx, NY, USA. 9. Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Valdemar Hansen Vej 5, DK-2600, Glostrup, Denmark. henrik.winther.schytz.01@regionh.dk.
Abstract
OBJECTIVE: To investigate the association of psychiatric and cognitive comorbidities with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI). METHODS: A total of 100 patients with persistent PTH attributed to mild TBI and 100 age- and gender-matched healthy controls free of mild TBI were enrolled between July 2018 and June 2019. Quality of sleep was evaluated using the Pittsburgh Sleep Quality Index, while symptoms of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Cognitive impairment was evaluated using the Montreal Cognitive Assessment questionnaire, while post-traumatic stress disorder (PTSD) was assessed using the Harvard Trauma Questionnaire. RESULTS: In 100 patients with persistent PTH, 85% reported poor quality sleep, compared with 42% of healthy controls (P < 0.01). The relative frequency of probable to high risk of anxiety was 52% in the persistent PTH group vs. 8% in healthy controls (P < 0.01), while the relative frequency of probable to high risk of depression was 42% in the persistent PTH group vs. 2% in healthy controls (P < 0.01). Furthermore, 27% of the patients with persistent PTH had mild cognitive impairment while 10% had probable PTSD. CONCLUSIONS: Poor quality of sleep as well as symptoms suggestive of anxiety and depression were more common in patients with persistent PTH than healthy controls. Clinicians should screen patients with persistent PTH for these comorbidities and develop treatment plans that account for their presence.
OBJECTIVE: To investigate the association of psychiatric and cognitive comorbidities with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI). METHODS: A total of 100 patients with persistent PTH attributed to mild TBI and 100 age- and gender-matched healthy controls free of mild TBI were enrolled between July 2018 and June 2019. Quality of sleep was evaluated using the Pittsburgh Sleep Quality Index, while symptoms of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Cognitive impairment was evaluated using the Montreal Cognitive Assessment questionnaire, while post-traumatic stress disorder (PTSD) was assessed using the Harvard Trauma Questionnaire. RESULTS: In 100 patients with persistent PTH, 85% reported poor quality sleep, compared with 42% of healthy controls (P < 0.01). The relative frequency of probable to high risk of anxiety was 52% in the persistent PTH group vs. 8% in healthy controls (P < 0.01), while the relative frequency of probable to high risk of depression was 42% in the persistent PTH group vs. 2% in healthy controls (P < 0.01). Furthermore, 27% of the patients with persistent PTH had mild cognitive impairment while 10% had probable PTSD. CONCLUSIONS: Poor quality of sleep as well as symptoms suggestive of anxiety and depression were more common in patients with persistent PTH than healthy controls. Clinicians should screen patients with persistent PTH for these comorbidities and develop treatment plans that account for their presence.
Authors: Håkan Ashina; Anna K Eigenbrodt; Tad Seifert; Alexandra J Sinclair; Ann I Scher; Henrik W Schytz; Mi Ji Lee; Roberto De Icco; Alan G Finkel; Messoud Ashina Journal: Lancet Neurol Date: 2021-06 Impact factor: 44.182
Authors: Doris Lieba-Samal; Patrick Platzer; Stefan Seidel; Petra Klaschterka; Astrid Knopf; Christian Wöber Journal: Cephalalgia Date: 2011-11-24 Impact factor: 6.292
Authors: Håkan Ashina; Afrim Iljazi; Faisal M Amin; Messoud Ashina; Richard B Lipton; Henrik W Schytz Journal: J Headache Pain Date: 2020-11-19 Impact factor: 7.277
Authors: Ángel González de la Flor; Guillermo García Pérez de Sevilla; Diego Domíngez Balmaseda; Daniel Martín Vera; María Montero Martínez; Jose Ángel Del Blanco Muñiz Journal: Behav Neurol Date: 2022-09-06 Impact factor: 3.112