Terril L Verplaetse1, MacKenzie R Peltier2, Walter Roberts3, Catherine Burke4, Kelly E Moore5, Brian Pittman6, Sherry A McKee7. 1. Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States. Electronic address: terril.verplaetse@yale.edu. 2. Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States; Psychology Service, Veterans Affairs Connecticut Healthcare System, West Haven, CT, United States. Electronic address: mackenzie.peltier@yale.edu. 3. Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States. Electronic address: walter.roberts@yale.edu. 4. Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States. Electronic address: catherine.burke@yale.edu. 5. Department of Psychology, East Tennessee State University, Johnson City, TN, United States. Electronic address: mooreke2@etsu.edu. 6. Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States. Electronic address: brian.pittman@yale.edu. 7. Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States. Electronic address: sherry.mckee@yale.edu.
Abstract
BACKGROUND: Women experience greater health consequences of alcohol compared to their male counterparts. In recent years, rates of drinking and heavy alcohol use have increased in women while remaining relatively steady in men. Thus, our aim was to newly examine associations between sex, AUD, and the presence of medical conditions in a large nationally representative, cross-sectional dataset. METHODS: Using data from the U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III; n = 36,309), we evaluated relationships among sex and DSM-5 AUD, and their association with past year clinician-confirmed medical conditions. RESULTS: Women were 1.5 to 2 times more likely to be diagnosed with a past year cancer, pain, respiratory, or other significant medical condition compared to men (odds ratio [OR] = 1.331-2.027). Individuals with an ongoing DSM-5 AUD were nearly 1.5 to 2 times more likely to report a confirmed past year liver, cardiovascular, cancer, or other significant medical condition compared to those without an AUD (OR = 1.437-2.073). Interactive effects demonstrated that women with an ongoing AUD were 2 to 3 times more likely to report a past year doctor- or health professional-confirmed medical condition compared to men; specifically, respiratory conditions and cancers (OR = 1.767-2.713). CONCLUSIONS: Results identify that AUD is a critical factor associated with disease that spans organ systems. Associations between AUD and respiratory conditions or cancers are particularly robust in women. Effective interventions for a broad spectrum of medical conditions should consider the role of problematic alcohol use, especially given that rates of drinking in women are increasing.
BACKGROUND: Women experience greater health consequences of alcohol compared to their male counterparts. In recent years, rates of drinking and heavy alcohol use have increased in women while remaining relatively steady in men. Thus, our aim was to newly examine associations between sex, AUD, and the presence of medical conditions in a large nationally representative, cross-sectional dataset. METHODS: Using data from the U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III; n = 36,309), we evaluated relationships among sex and DSM-5 AUD, and their association with past year clinician-confirmed medical conditions. RESULTS: Women were 1.5 to 2 times more likely to be diagnosed with a past year cancer, pain, respiratory, or other significant medical condition compared to men (odds ratio [OR] = 1.331-2.027). Individuals with an ongoing DSM-5 AUD were nearly 1.5 to 2 times more likely to report a confirmed past year liver, cardiovascular, cancer, or other significant medical condition compared to those without an AUD (OR = 1.437-2.073). Interactive effects demonstrated that women with an ongoing AUD were 2 to 3 times more likely to report a past year doctor- or health professional-confirmed medical condition compared to men; specifically, respiratory conditions and cancers (OR = 1.767-2.713). CONCLUSIONS: Results identify that AUD is a critical factor associated with disease that spans organ systems. Associations between AUD and respiratory conditions or cancers are particularly robust in women. Effective interventions for a broad spectrum of medical conditions should consider the role of problematic alcohol use, especially given that rates of drinking in women are increasing.
Authors: Bridget F Grant; Risë B Goldstein; Tulshi D Saha; S Patricia Chou; Jeesun Jung; Haitao Zhang; Roger P Pickering; W June Ruan; Sharon M Smith; Boji Huang; Deborah S Hasin Journal: JAMA Psychiatry Date: 2015-08 Impact factor: 21.596
Authors: Terril L Verplaetse; Kelly E Moore; Brian P Pittman; Walter Roberts; Lindsay M Oberleitner; Mac Kenzie R Peltier; Robyn Hacker; Kelly P Cosgrove; Sherry A McKee Journal: Nicotine Tob Res Date: 2019-09-19 Impact factor: 4.244
Authors: Bridget F Grant; S Patricia Chou; Tulshi D Saha; Roger P Pickering; Bradley T Kerridge; W June Ruan; Boji Huang; Jeesun Jung; Haitao Zhang; Amy Fan; Deborah S Hasin Journal: JAMA Psychiatry Date: 2017-09-01 Impact factor: 21.596
Authors: Richard A Grucza; Kenneth J Sher; William C Kerr; Melissa J Krauss; Camillia K Lui; Yoanna E McDowell; Sarah Hartz; Gurpal Virdi; Laura J Bierut Journal: Alcohol Clin Exp Res Date: 2018-08-23 Impact factor: 3.455