Literature DB >> 34311100

ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores.

Milena S Marcolino1, Magda C Pires2, Lucas Emanuel F Ramos3, Rafael T Silva4, Luana M Oliveira5, Rafael L R Carvalho6, Rodolfo Lucas S Mourato7, Adrián Sánchez-Montalvá8, Berta Raventós9, Fernando Anschau10, José Miguel Chatkin11, Matheus C A Nogueira12, Milton H Guimarães Júnior13, Giovanna G Vietta14, Helena Duani15, Daniela Ponce16, Patricia K Ziegelmann17, Luís C Castro18, Karen B Ruschel19, Christiane C R Cimini20, Saionara C Francisco21, Maiara A Floriani22, Guilherme F Nascimento23, Bárbara L Farace24, Luanna S Monteiro25, Maira V R Souza-Silva26, Thais L S Sales27, Karina Paula M P Martins28, Israel J Borges do Nascimento29, Tatiani O Fereguetti30, Daniel T M O Ferrara31, Fernando A Botoni32, Ana Paula B S Etges33, Eric Boersma34, Carisi A Polanczyk35, Alexandre V Schwarzbold36, Amanda O Maurílio37, Ana Luiza B A Scotton38, André P Weber39, André S M Costa40, Andressa B Glaeser41, Angélica Aparecida C Madureira42, Angelinda R Bhering43, Bruno Mateus de Castro44, Carla Thais C A da Silva45, Carolina M Ramos46, Caroline D Gomes47, Cíntia A de Carvalho48, Daniel V Silveira49, Edilson Cezar50, Elayne C Pereira51, Emanuele Marianne S Kroger52, Felipe B Vallt53, Fernanda B Lucas54, Fernando G Aranha55, Frederico Bartolazzi56, Gabriela P Crestani57, Gisele A N Bastos58, Glícia Cristina de C Madeira59, Helena Carolina Noal60, Heloisa R Vianna61, Henrique C Guimarães62, Isabela M Gomes63, Israel M Romero64, Joanna D L Batista65, Joice C de Alvarenga66, Júlia D S S Guimarães67, Júlia D P de Morais68, Juliana M Rugolo69, Karen Cristina J R Pontes70, Kauane Aline M Dos Santos71, Leonardo S de Oliveira72, Lílian S Pinheiro73, Liliane S Pacheco74, Lucas de D Sousa75, Luciana S F Couto76, Luciane Kopittke77, Luis Cesar S de Moura78, Luisa Elem A Santos79, Máderson A S Cabral80, Maíra D Souza81, Marcela G T Tofani82, Marcelo Carneiro83, Maria Angélica P Ferreira84, Maria Aparecida C Bicalho85, Maria Clara P B Lima86, Mariana F Godoy87, Marilia M A Cardoso88, Meire P Figueiredo89, Natália C S Sampaio90, Natália L Rangel91, Natália T Crespo92, Neimy R de Oliveira93, Pedro L Assaf94, Petrônio José de L Martelli95, Rafaela S C Almeida96, Raphael C Martins97, Raquel Lutkmeier98, Reginaldo Aparecido Valacio99, Renan G Finger100, Ricardo B Cardoso101, Roberta Pozza102, Roberta X Campos103, Rochele M Menezes104, Roger M de Abreu105, Rufino de F Silva106, Silvana M M Guimarães107, Silvia F Araújo108, Susany Anastácia Pereira109, Talita F Oliveira110, Tatiana Kurtz111, Thainara C de Oliveira112, Thaíza Simônia M A Araújo113, Thulio Henrique O Diniz114, Veridiana B Dos Santos115, Virginia Mara R Gomes116, Vitor Augusto L do Vale117, Yuri C Ramires118.   

Abstract

OBJECTIVES: The majority of available scores to assess mortality risk of coronavirus disease 19 (COVID-19) patients in the emergency department have high risk of bias. Therefore, our aim was to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients, and to compare this score with other existing ones.
METHODS: Consecutive patients (≥18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between March-July, 2020. The model was validated in the 1054 patients admitted during August-September, as well as in an external cohort of 474 Spanish patients.
RESULTS: Median (25th-75th percentile) age of the model-derivation cohort was 60 (48-72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO2/FiO2 ratio, platelet count and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829 to 0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833 to 0.885]) and Spanish (0.894 [95% CI 0.870 to 0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/).
CONCLUSIONS: We designed and validated an easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation, for early stratification for in-hospital mortality risk of patients with COVID-19.
Copyright © 2021. Published by Elsevier Ltd.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; hospitalizations; mortality; prognosis; risk factors; score

Year:  2021        PMID： 34311100     DOI： 10.1016/j.ijid.2021.07.049

Source DB:  PubMed          Journal:  Int J Infect Dis        ISSN： 1201-9712            Impact factor:   3.623


  7 in total

1.  Predictors of venous thromboembolism in COVID-19 patients: results of the COVID-19 Brazilian Registry.

Authors:  Warley Cezar da Silveira; Lucas Emanuel Ferreira Ramos; Rafael Tavares Silva; Bruno Barbosa Miranda de Paiva; Polianna Delfino Pereira; Alexandre Vargas Schwarzbold; Andresa Fontoura Garbini; Bruna Schettino Morato Barreira; Bruno Mateus de Castro; Carolina Marques Ramos; Caroline Danubia Gomes; Christiane Corrêa Rodrigues Cimini; Elayne Crestani Pereira; Eliane Würdig Roesch; Emanuele Marianne Souza Kroger; Felipe Ferraz Martins Graça Aranha; Fernando Anschau; Fernando Antonio Botoni; Fernando Graça Aranha; Gabriela Petry Crestani; Giovanna Grunewald Vietta; Gisele Alsina Nader Bastos; Jamille Hemétrio Salles Martins Costa; Jéssica Rayane Corrêa Silva da Fonseca; Karen Brasil Ruschel; Leonardo Seixas de Oliveira; Lílian Santos Pinheiro; Liliane Souto Pacheco; Luciana Borges Segala; Luciana Siuves Ferreira Couto; Luciane Kopittke; Maiara Anschau Floriani; Majlla Magalhães Silva; Marcelo Carneiro; Maria Angélica Pires Ferreira; Maria Auxiliadora Parreiras Martins; Marina Neves Zerbini de Faria; Matheus Carvalho Alves Nogueira; Milton Henriques Guimarães Júnior; Natália da Cunha Severino Sampaio; Neimy Ramos de Oliveira; Nicole de Moraes Pertile; Pedro Guido Soares Andrade; Pedro Ledic Assaf; Reginaldo Aparecido Valacio; Rochele Mosmann Menezes; Saionara Cristina Francisco; Silvana Mangeon Meirelles Guimarães; Silvia Ferreira Araújo; Suely Meireles Rezende; Susany Anastácia Pereira; Tatiana Kurtz; Tatiani Oliveira Fereguetti; Carísi Anne Polanczyk; Magda Carvalho Pires; Marcos André Gonçalves; Milena Soriano Marcolino
Journal:  Intern Emerg Med       Date:  2022-06-01       Impact factor: 5.472

2.  Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study.

Authors:  Adrián Sánchez-Montalvá; Daniel Álvarez-Sierra; Mónica Martínez-Gallo; Janire Perurena-Prieto; Iria Arrese-Muñoz; Juan Carlos Ruiz-Rodríguez; Juan Espinosa-Pereiro; Pau Bosch-Nicolau; Xavier Martínez-Gómez; Andrés Antón; Ferran Martínez-Valle; Mar Riveiro-Barciela; Albert Blanco-Grau; Francisco Rodríguez-Frias; Pol Castellano-Escuder; Elisabet Poyatos-Canton; Jordi Bas-Minguet; Eva Martínez-Cáceres; Alex Sánchez-Pla; Coral Zurera-Egea; Aina Teniente-Serra; Manuel Hernández-González; Ricardo Pujol-Borrell
Journal:  Front Immunol       Date:  2022-06-29       Impact factor: 8.786

3.  Usefulness of the C2HEST Score in Predicting the Clinical Outcomes of COVID-19 in Diabetic and Non-Diabetic Cohorts.

Authors:  Damian Gajecki; Adrian Doroszko; Małgorzata Trocha; Katarzyna Giniewicz; Krzysztof Kujawa; Marek Skarupski; Jakub Gawryś; Tomasz Matys; Ewa Szahidewicz-Krupska; Piotr Rola; Barbara Stachowska; Jowita Halupczok-Żyła; Barbara Adamik; Krzysztof Kaliszewski; Katarzyna Kilis-Pstrusinska; Krzysztof Letachowicz; Agnieszka Matera-Witkiewicz; Michał Pomorski; Marcin Protasiewicz; Marcin Madziarski; Klaudia Konikowska; Agata Remiorz; Maja Orłowska; Krzysztof Proc; Małgorzata Szymala-Pedzik; Joanna Zorawska; Karolina Lindner; Janusz Sokołowski; Ewa A Jankowska; Katarzyna Madziarska
Journal:  J Clin Med       Date:  2022-02-07       Impact factor: 4.241

4.  The role of a noninvasive index 'Spo2/ Fio2' in predicting mortality among patients with COVID-19 pneumonia.

Authors:  Merve Osoydan Satici; Mehmet Muzaffer Islam; Celal Satici; Cemre Nur Uygun; Enis Ademoglu; İbrahim Altunok; Gokhan Aksel; Serkan Emre Eroglu
Journal:  Am J Emerg Med       Date:  2022-04-27       Impact factor: 4.093

5.  A Machine Learning Model for Predicting Hospitalization in Patients with Respiratory Symptoms during the COVID-19 Pandemic.

Authors:  Victor Muniz De Freitas; Daniela Mendes Chiloff; Giulia Gabriella Bosso; Janaina Oliveira Pires Teixeira; Isabele Cristina de Godói Hernandes; Maira do Patrocínio Padilha; Giovanna Corrêa Moura; Luis Gustavo Modelli De Andrade; Frederico Mancuso; Francisco Estivallet Finamor; Aluísio Marçal de Barros Serodio; Jaquelina Sonoe Ota Arakaki; Marair Gracio Ferreira Sartori; Paulo Roberto Abrão Ferreira; Érika Bevilaqua Rangel
Journal:  J Clin Med       Date:  2022-08-05       Impact factor: 4.964

6.  Hospital characteristics associated with COVID-19 mortality: data from the multicenter cohort Brazilian Registry.

Authors:  Maira Viana Rego Souza-Silva; Patricia Klarmann Ziegelmann; Vandack Nobre; Virginia Mara Reis Gomes; Ana Paula Beck da Silva Etges; Alexandre Vargas Schwarzbold; Aline Gabrielle Sousa Nunes; Amanda de Oliveira Maurílio; Ana Luiza Bahia Alves Scotton; André Soares de Moura Costa; Andressa Barreto Glaeser; Bárbara Lopes Farace; Bruno Nunes Ribeiro; Carolina Marques Ramos; Christiane Corrêa Rodrigues Cimini; Cíntia Alcantara de Carvalho; Claudete Rempel; Daniel Vitório Silveira; Daniela Dos Reis Carazai; Daniela Ponce; Elayne Crestani Pereira; Emanuele Marianne Souza Kroger; Euler Roberto Fernandes Manenti; Evelin Paola de Almeida Cenci; Fernanda Barbosa Lucas; Fernanda Costa Dos Santos; Fernando Anschau; Fernando Antonio Botoni; Fernando Graça Aranha; Filipe Carrilho de Aguiar; Frederico Bartolazzi; Gabriela Petry Crestani; Giovanna Grunewald Vietta; Guilherme Fagundes Nascimento; Helena Carolina Noal; Helena Duani; Heloisa Reniers Vianna; Henrique Cerqueira Guimarães; Joice Coutinho de Alvarenga; José Miguel Chatkin; Júlia Drumond Parreiras de Morais; Juliana da Silva Nogueira Carvalho; Juliana Machado Rugolo; Karen Brasil Ruschel; Lara de Barros Wanderley Gomes; Leonardo Seixas de Oliveira; Liege Barella Zandoná; Lílian Santos Pinheiro; Liliane Souto Pacheco; Luanna da Silva Monteiro Menezes; Lucas de Deus Sousa; Luis Cesar Souto de Moura; Luisa Elem Almeida Santos; Luiz Antonio Nasi; Máderson Alvares de Souza Cabral; Maiara Anschau Floriani; Maíra Dias Souza; Marcelo Carneiro; Mariana Frizzo de Godoy; Marilia Mastrocolla de Almeida Cardoso; Matheus Carvalho Alves Nogueira; Mauro Oscar Soares de Souza Lima; Meire Pereira de Figueiredo; Milton Henriques Guimarães-Júnior; Natália da Cunha Severino Sampaio; Neimy Ramos de Oliveira; Pedro Guido Soares Andrade; Pedro Ledic Assaf; Petrônio José de Lima Martelli; Raphael Castro Martins; Reginaldo Aparecido Valacio; Roberta Pozza; Rochele Mosmann Menezes; Rodolfo Lucas Silva Mourato; Roger Mendes de Abreu; Rufino de Freitas Silva; Saionara Cristina Francisco; Silvana Mangeon Mereilles Guimarães; Silvia Ferreira Araújo; Talita Fischer Oliveira; Tatiana Kurtz; Tatiani Oliveira Fereguetti; Thainara Conceição de Oliveira; Yara Cristina Neves Marques Barbosa Ribeiro; Yuri Carlotto Ramires; Carísi Anne Polanczyk; Milena Soriano Marcolino
Journal:  Intern Emerg Med       Date:  2022-09-25       Impact factor: 5.472

7.  Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry.

Authors:  Daniella Nunes Pereira; Leticia Ferreira Gontijo Silveira; Milena Maria Moreira Guimarães; Carísi Anne Polanczyk; Aline Gabrielle Sousa Nunes; André Soares de Moura Costa; Barbara Lopes Farace; Christiane Corrêa Rodrigues Cimini; Cíntia Alcantara de Carvalho; Daniela Ponce; Eliane Würdig Roesch; Euler Roberto Fernandes Manenti; Fernanda Barbosa Lucas; Fernanda d'Athayde Rodrigues; Fernando Anschau; Fernando Graça Aranha; Frederico Bartolazzi; Giovanna Grunewald Vietta; Guilherme Fagundes Nascimento; Helena Duani; Heloisa Reniers Vianna; Henrique Cerqueira Guimarães; Jamille Hemétrio Salles Martins Costa; Joanna d'Arc Lyra Batista; Joice Coutinho de Alvarenga; José Miguel Chatkin; Júlia Drumond Parreiras de Morais; Juliana Machado-Rugolo; Karen Brasil Ruschel; Lílian Santos Pinheiro; Luanna Silva Monteiro Menezes; Luciana Siuves Ferreira Couto; Luciane Kopittke; Luís César de Castro; Luiz Antônio Nasi; Máderson Alvares de Souza Cabral; Maiara Anschau Floriani; Maíra Dias Souza; Marcelo Carneiro; Maria Aparecida Camargos Bicalho; Mariana Frizzo de Godoy; Matheus Carvalho Alves Nogueira; Milton Henriques Guimarães Júnior; Natália da Cunha Severino Sampaio; Neimy Ramos de Oliveira; Pedro Ledic Assaf; Renan Goulart Finger; Roberta Xavier Campos; Rochele Mosmann Menezes; Saionara Cristina Francisco; Samuel Penchel Alvarenga; Silvana Mangeon Mereilles Guimarães; Silvia Ferreira Araújo; Talita Fischer Oliveira; Thulio Henrique Oliveira Diniz; Yuri Carlotto Ramires; Evelin Paola de Almeida Cenci; Thainara Conceição de Oliveira; Alexandre Vargas Schwarzbold; Patricia Klarmann Ziegelmann; Roberta Pozza; Caroline Scherer Carvalho; Magda Carvalho Pires; Milena Soriano Marcolino
Journal:  Int J Infect Dis       Date:  2022-01-19       Impact factor: 12.074
  7 in total

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