Yangwen Chen1, Qian Chai1, Qian Wang1, Ziying Zhang1, Yongyan Shan1, Dexue Lu1, Meili Liu1, Weihua Wu2. 1. Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China. 2. Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China. Electronic address: wwh_2678@163.com.
Abstract
AIMS: Our study is aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and coronary microvascular dysfunction (CMD) in type 2 diabetes mellitus (T2DM) patients. METHODS: We retrospect the consecutive medical files of 160 T2DM patients and recorded their clinical information and laboratory findings. Patients were divided into CMD group (n=87) and non-CMD group (n=73). We compared the NLR values of the two groups. Meanwhile we also observed the prevalence of CMD at different NLR levels. Then, logistic regression and ROC analysis were performed. RESULTS: NLR value of CMD group was significantly lower than non-CMD group (2.01±0.74 vs 2.53±0.69, P＜0.001). Prevalence of CMD in low (NLR≤1.53, n=30), medium (1.53<NLR≤2.20, n=53) and high (NLR>2.20, n=77) group were 90%, 61.1%, and 39.2% respectively. The prevalence of CMD significantly increased as NLR level decreased. After adjusting potential related factors, NLR was still significantly correlated with CMD (OR=0.295, 95%CI:0.162-0.539, P<0.001). The area under ROC curve (AUC) was 0.707 (95%CI:0.627-0.786, P<0.001). CONCLUSIONS: Our results showed that NLR is associated with CMD in T2DM patients, and the prevalence of CMD may increase as NLR level decrease.
AIMS: Our study is aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and coronary microvascular dysfunction (CMD) in type 2 diabetes mellitus (T2DM) patients. METHODS: We retrospect the consecutive medical files of 160 T2DM patients and recorded their clinical information and laboratory findings. Patients were divided into CMD group (n=87) and non-CMD group (n=73). We compared the NLR values of the two groups. Meanwhile we also observed the prevalence of CMD at different NLR levels. Then, logistic regression and ROC analysis were performed. RESULTS: NLR value of CMD group was significantly lower than non-CMD group (2.01±0.74 vs 2.53±0.69, P＜0.001). Prevalence of CMD in low (NLR≤1.53, n=30), medium (1.53<NLR≤2.20, n=53) and high (NLR>2.20, n=77) group were 90%, 61.1%, and 39.2% respectively. The prevalence of CMD significantly increased as NLR level decreased. After adjusting potential related factors, NLR was still significantly correlated with CMD (OR=0.295, 95%CI:0.162-0.539, P<0.001). The area under ROC curve (AUC) was 0.707 (95%CI:0.627-0.786, P<0.001). CONCLUSIONS: Our results showed that NLR is associated with CMD in T2DM patients, and the prevalence of CMD may increase as NLR level decrease.