INTRODUCTION: The prognostic utility of cerebrospinal fluid (CSF) phosphorylated tau 217 (p-tau217) and p-tau181 is not understood. METHODS: Analyses included 753 Mayo Clinic Study on Aging participants (median age = 71.6; 57% male). CSF amyloid beta (Aβ)42 and p-tau181 were measured with Elecsys immunoassays. CSF p-tau181 and p-tau217 were also measured with Meso Scale Discovery (MSD). We used Cox proportional hazards models for risk of mild cognitive impairment (MCI) and linear mixed models for risk of global and domain-specific cognitive decline and cortical thickness. Analyses were stratified by elevated brain amyloid based on CSF Aβ42 or amyloid positron emission tomography for those with imaging. RESULTS: CSF p-tau217 was superior to p-tau181 for the diagnosis of Alzheimer's disease (AD) pathology. CSF MSD p-tau181 and p-tau217 were associated with risk of MCI among amyloid-positive individuals. Differences between CSF p-tau measures predicting cortical thickness were subtle. DISCUSSION: There are subtle differences for CSF p-tau217 and p-tau181 as prognostic AD markers.
INTRODUCTION: The prognostic utility of cerebrospinal fluid (CSF) phosphorylated tau 217 (p-tau217) and p-tau181 is not understood. METHODS: Analyses included 753 Mayo Clinic Study on Aging participants (median age = 71.6; 57% male). CSF amyloid beta (Aβ)42 and p-tau181 were measured with Elecsys immunoassays. CSF p-tau181 and p-tau217 were also measured with Meso Scale Discovery (MSD). We used Cox proportional hazards models for risk of mild cognitive impairment (MCI) and linear mixed models for risk of global and domain-specific cognitive decline and cortical thickness. Analyses were stratified by elevated brain amyloid based on CSF Aβ42 or amyloid positron emission tomography for those with imaging. RESULTS: CSF p-tau217 was superior to p-tau181 for the diagnosis of Alzheimer's disease (AD) pathology. CSF MSD p-tau181 and p-tau217 were associated with risk of MCI among amyloid-positive individuals. Differences between CSF p-tau measures predicting cortical thickness were subtle. DISCUSSION: There are subtle differences for CSF p-tau217 and p-tau181 as prognostic AD markers.
Authors: Valeria Lifke; Gwendlyn Kollmorgen; Ekaterina Manuilova; Tobias Oelschlaegel; Lars Hillringhaus; Monika Widmann; Christine A F von Arnim; Markus Otto; Robert H Christenson; Jennifer L Powers; Leslie M Shaw; Oskar Hansson; James D Doecke; Qiao-Xin Li; Charlotte Teunissen; Hayrettin Tumani; Kaj Blennow Journal: Clin Biochem Date: 2019-05-23 Impact factor: 3.281
Authors: Val J Lowe; Bradley J Kemp; Clifford R Jack; Matthew Senjem; Stephen Weigand; Maria Shiung; Glenn Smith; David Knopman; Bradley Boeve; Brian Mullan; Ronald C Petersen Journal: J Nucl Med Date: 2009-05-14 Impact factor: 10.057
Authors: Bob Olsson; Ronald Lautner; Ulf Andreasson; Annika Öhrfelt; Erik Portelius; Maria Bjerke; Mikko Hölttä; Christoffer Rosén; Caroline Olsson; Gabrielle Strobel; Elizabeth Wu; Kelly Dakin; Max Petzold; Kaj Blennow; Henrik Zetterberg Journal: Lancet Neurol Date: 2016-04-08 Impact factor: 44.182
Authors: Harald Hampel; Katharina Buerger; Raymond Zinkowski; Stefan J Teipel; Alexander Goernitz; Niels Andreasen; Magnus Sjoegren; John DeBernardis; Daniel Kerkman; Koichi Ishiguro; Hideto Ohno; Eugeen Vanmechelen; Hugo Vanderstichele; Cheryl McCulloch; Hans-Jurgen Moller; Peter Davies; Kaj Blennow Journal: Arch Gen Psychiatry Date: 2004-01
Authors: Kaj Blennow; Chun Chen; Claudia Cicognola; Kristin R Wildsmith; Paul T Manser; Sandra M Sanabria Bohorquez; Zhentao Zhang; Boer Xie; Junmin Peng; Oskar Hansson; Hlin Kvartsberg; Erik Portelius; Henrik Zetterberg; Tammaryn Lashley; Gunnar Brinkmalm; Geoffrey A Kerchner; Robby M Weimer; Keqiang Ye; Kina Höglund Journal: Brain Date: 2020-02-01 Impact factor: 13.501
Authors: Clifford R Jack; Val J Lowe; Matthew L Senjem; Stephen D Weigand; Bradley J Kemp; Maria M Shiung; David S Knopman; Bradley F Boeve; William E Klunk; Chester A Mathis; Ronald C Petersen Journal: Brain Date: 2008-02-07 Impact factor: 13.501
Authors: Rosebud O Roberts; Yonas E Geda; David S Knopman; Ruth H Cha; V Shane Pankratz; Bradley F Boeve; Robert J Ivnik; Eric G Tangalos; Ronald C Petersen; Walter A Rocca Journal: Neuroepidemiology Date: 2008-02-07 Impact factor: 3.282
Authors: Niklas Mattsson-Carlgren; Emelie Andersson; Shorena Janelidze; Rik Ossenkoppele; Philip Insel; Olof Strandberg; Henrik Zetterberg; Howard J Rosen; Gil Rabinovici; Xiyun Chai; Kaj Blennow; Jeffrey L Dage; Erik Stomrud; Ruben Smith; Sebastian Palmqvist; Oskar Hansson Journal: Sci Adv Date: 2020-04-15 Impact factor: 14.136
Authors: Shorena Janelidze; Henrik Zetterberg; Niklas Mattsson; Sebastian Palmqvist; Hugo Vanderstichele; Olof Lindberg; Danielle van Westen; Erik Stomrud; Lennart Minthon; Kaj Blennow; Oskar Hansson Journal: Ann Clin Transl Neurol Date: 2016-01-01 Impact factor: 4.511
Authors: Shorena Janelidze; Erik Stomrud; Ruben Smith; Sebastian Palmqvist; Niklas Mattsson; David C Airey; Nicholas K Proctor; Xiyun Chai; Sergey Shcherbinin; John R Sims; Gallen Triana-Baltzer; Clara Theunis; Randy Slemmon; Marc Mercken; Hartmuth Kolb; Jeffrey L Dage; Oskar Hansson Journal: Nat Commun Date: 2020-04-03 Impact factor: 14.919
Authors: Daniel W Sirkis; Luke W Bonham; Taylor P Johnson; Renaud La Joie; Jennifer S Yokoyama Journal: Mol Psychiatry Date: 2022-04-07 Impact factor: 13.437