Mahdi Sheikh1, Anush Mukeriya2, Oxana Shangina2, Paul Brennan1, David Zaridze2. 1. International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, Lyon, France (M.S., P.B.). 2. N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia (A.M., O.S., D.Z.).
Abstract
BACKGROUND: Lung cancer is the leading cause of cancer death worldwide, and about one half of patients with lung cancer are active smokers at diagnosis. OBJECTIVE: To determine whether quitting smoking after diagnosis of lung cancer affects the risk for disease progression and mortality. DESIGN: Prospective study of patients with non-small cell lung cancer (NSCLC) who were recruited between 2007 and 2016 and followed annually through 2020. SETTING: N.N. Blokhin National Medical Research Center of Oncology and City Clinical Oncological Hospital No. 1, Moscow, Russia. PATIENTS: 517 current smokers who were diagnosed with early-stage (IA-IIIA) NSCLC. MEASUREMENTS: Probabilities of overall survival, progression-free survival, and lung cancer-specific mortality and hazard ratios (HRs) for all-cause and cancer-specific mortality. RESULTS: During an average of 7 years of follow-up, 327 (63.2%) deaths, 273 (52.8%) cancer-specific deaths, and 172 (33.7%) cases of tumor progression (local recurrence or metastasis) were recorded. The adjusted median overall survival time was 21.6 months higher among patients who had quit smoking than those who continued smoking (6.6 vs. 4.8 years, respectively; P = 0.001). Higher 5-year overall survival (60.6% vs. 48.6%; P = 0.001) and progression-free survival (54.4% vs. 43.8%; P = 0.004) were observed among patients who quit than those who continued smoking. After adjustments, smoking cessation remained associated with decreased risk for all-cause mortality (HR, 0.67 [95% CI, 0.53 to 0.85]), cancer-specific mortality (HR, 0.75 [CI, 0.58 to 0.98]), and disease progression (HR, 0.70 [CI, 0.56 to 0.89]). Similar effects were observed among mild to moderate and heavy smokers and patients with earlier and later cancer stages. LIMITATION: Exposure measurements were based on self-reported questionnaires. CONCLUSION: Smoking cessation after diagnosis materially improved overall and progression-free survival among current smokers with early-stage lung cancer.
BACKGROUND:Lung cancer is the leading cause of cancer death worldwide, and about one half of patients with lung cancer are active smokers at diagnosis. OBJECTIVE: To determine whether quitting smoking after diagnosis of lung cancer affects the risk for disease progression and mortality. DESIGN: Prospective study of patients with non-small cell lung cancer (NSCLC) who were recruited between 2007 and 2016 and followed annually through 2020. SETTING: N.N. Blokhin National Medical Research Center of Oncology and City Clinical Oncological Hospital No. 1, Moscow, Russia. PATIENTS: 517 current smokers who were diagnosed with early-stage (IA-IIIA) NSCLC. MEASUREMENTS: Probabilities of overall survival, progression-free survival, and lung cancer-specific mortality and hazard ratios (HRs) for all-cause and cancer-specific mortality. RESULTS: During an average of 7 years of follow-up, 327 (63.2%) deaths, 273 (52.8%) cancer-specific deaths, and 172 (33.7%) cases of tumor progression (local recurrence or metastasis) were recorded. The adjusted median overall survival time was 21.6 months higher among patients who had quit smoking than those who continued smoking (6.6 vs. 4.8 years, respectively; P = 0.001). Higher 5-year overall survival (60.6% vs. 48.6%; P = 0.001) and progression-free survival (54.4% vs. 43.8%; P = 0.004) were observed among patients who quit than those who continued smoking. After adjustments, smoking cessation remained associated with decreased risk for all-cause mortality (HR, 0.67 [95% CI, 0.53 to 0.85]), cancer-specific mortality (HR, 0.75 [CI, 0.58 to 0.98]), and disease progression (HR, 0.70 [CI, 0.56 to 0.89]). Similar effects were observed among mild to moderate and heavy smokers and patients with earlier and later cancer stages. LIMITATION: Exposure measurements were based on self-reported questionnaires. CONCLUSION: Smoking cessation after diagnosis materially improved overall and progression-free survival among current smokers with early-stage lung cancer.
Authors: Xinan Wang; Biagio Ricciuti; Joao V Alessi; Tom Nguyen; Mark M Awad; Xihong Lin; Bruce E Johnson; David C Christiani Journal: J Natl Cancer Inst Date: 2022-03-08 Impact factor: 11.816
Authors: Stephanie R Land; Laura Baker; Jacqueline Bachand; Jenny Twesten; Annette R Kaufman; Carolyn M Reyes-Guzman Journal: Nicotine Tob Res Date: 2022-10-17 Impact factor: 5.825
Authors: Brendan T Heiden; Daniel B Eaton; Su-Hsin Chang; Yan Yan; Martin W Schoen; Li-Shiun Chen; Nina Smock; Mayank R Patel; Daniel Kreisel; Ruben G Nava; Bryan F Meyers; Benjamin D Kozower; Varun Puri Journal: Chest Date: 2021-12-14 Impact factor: 10.262
Authors: Samantha Groves; Grace McCutchan; Samantha L Quaife; Rachael L Murray; Jamie S Ostroff; Kate Brain; Philip A J Crosbie; Janelle Yorke; David Baldwin; John K Field; Lorna McWilliams Journal: Health Expect Date: 2022-05-05 Impact factor: 3.318
Authors: Manan M Nayak; Emanuele Mazzola; Michael T Jaklitsch; Jeremy E Drehmer; Emara Nabi-Burza; Raphael Bueno; Jonathan P Winickoff; Mary E Cooley Journal: Tob Induc Dis Date: 2022-07-04 Impact factor: 5.163
Authors: Chao Ma; Rui-Jie Ma; Kang Hu; Qi-Ming Zheng; Ye-Peng Wang; Nan Zhang; Zhi-Gang Sun Journal: Cancer Cell Int Date: 2022-03-24 Impact factor: 5.722