Hongshi Li1, Dongxia Li1, Guizhi Zhao1, Yuan Gao1, Jie Ke2. 1. Institute of Stomatology, The Medical Center of Air Force of PLA, Beijing 100142, China. 2. Institute of Stomatology, The Medical Center of Air Force of PLA, Beijing 100142, China. cnhongshili@163.com.
Abstract
PURPOSE: To investigate the effects of Danggui-Shaoyao-San (DSS) on depression- and anxiety-like behavior induced by experimental tooth movement (ETM) in rats. MATERIALS AND METHODS: Thirty-six rats were randomly divided into a sham group (n = 12; rats underwent all operation procedures, except placement of orthodontic forces, and received saline treatment), ETM group (n = 12; rats received saline treatment and ETM), and DETM group (n = 12; rats received DSS [dose: 150 mg/kg twice daily from preoperative day 5 to postoperative day 7] treatment and ETM). The vacuous chewing movement (VCM) test, open-field test, and elevated plus maze test were performed to assess the depression- and anxiety-like behaviors of the rats. RESULTS: DSS pretreatment significantly decreased the ETM-induced VCM time (P < 0.05, DETM vs. ETM), increased the ETM-induced time to the central area of experimental device during the 5 min open-field test (P < 0.05, DETM vs. ETM), and increased the ratio of time spent in the open arms of the 5 min elevated plus maze test induced by ETM (P < 0.01, DETM vs. ETM). CONCLUSIONS: DSS pretreatment can restore the impaired abilities of rats caused by ETM-induced depression- and anxiety-like behavior.
PURPOSE: To investigate the effects of Danggui-Shaoyao-San (DSS) on depression- and anxiety-like behavior induced by experimental tooth movement (ETM) in rats. MATERIALS AND METHODS: Thirty-six rats were randomly divided into a sham group (n = 12; rats underwent all operation procedures, except placement of orthodontic forces, and received saline treatment), ETM group (n = 12; rats received saline treatment and ETM), and DETM group (n = 12; rats received DSS [dose: 150 mg/kg twice daily from preoperative day 5 to postoperative day 7] treatment and ETM). The vacuous chewing movement (VCM) test, open-field test, and elevated plus maze test were performed to assess the depression- and anxiety-like behaviors of the rats. RESULTS: DSS pretreatment significantly decreased the ETM-induced VCM time (P < 0.05, DETM vs. ETM), increased the ETM-induced time to the central area of experimental device during the 5 min open-field test (P < 0.05, DETM vs. ETM), and increased the ratio of time spent in the open arms of the 5 min elevated plus maze test induced by ETM (P < 0.01, DETM vs. ETM). CONCLUSIONS: DSS pretreatment can restore the impaired abilities of rats caused by ETM-induced depression- and anxiety-like behavior.
Authors: Jinfei Yang; Chenrui Li; Yan Liu; Yachun Han; Hao Zhao; Shilu Luo; Chanyue Zhao; Na Jiang; Ming Yang; Lin Sun Journal: Front Pharmacol Date: 2022-08-19 Impact factor: 5.988