Literature DB >> 34309174

Consequences of hemophagocytic lymphohistiocytosis-like cytokine release syndrome toxicities and concurrent bacteremia.

Katherine E Masih1,2, John A Ligon3, Bonnie Yates3, Haneen Shalabi3, Lauren Little3, Zahin Islam1, Amanda K Ombrello4, Jon Inglefield5, Veronique Nussenblatt6, Maura Manion6, Javed Khan1, Nirali N Shah3.   

Abstract

Serious bacterial infections (SBI) can lead to devastating complications with CD19 CAR T cells and cytokine release syndrome (CRS). Little is known about consequences of and risk factors for SBI with novel CAR T-cell constructs or with CRS complicated by HLH-like toxicities. We report on three patients with B-cell acute lymphoblastic leukemia treated with CD22 CAR T cells who developed SBI and CRS-associated HLH. Serum cytokine profiling revealed sustained elevations well beyond CRS resolution, suggesting ongoing systemic inflammation. Heightened inflammatory states converging with SBI contribute to poor outcomes, and recognition and prevention of extended inflammation may be needed to improve outcomes.
© 2021 Wiley Periodicals LLC.

Entities:  

Keywords:  ALL molecular diagnosis and therapy; ALL relapse; clinical trials; cytokines; immunotherapy; infections

Mesh：

Substances：

Year:  2021        PMID： 34309174      PMCID： PMC9410765          DOI： 10.1002/pbc.29247

Source DB:  PubMed          Journal:  Pediatr Blood Cancer        ISSN： 1545-5009            Impact factor:   3.838


  13 in total

1.  Infectious complications of CD19-targeted chimeric antigen receptor-modified T-cell immunotherapy.

Authors:  Joshua A Hill; Daniel Li; Kevin A Hay; Margaret L Green; Sindhu Cherian; Xueyan Chen; Stanley R Riddell; David G Maloney; Michael Boeckh; Cameron J Turtle
Journal:  Blood       Date:  2017-10-16       Impact factor: 22.113

2.  Bacillus cereus bacteremia and multiple brain abscesses during acute lymphoblastic leukemia induction therapy.

Authors:  Jordan R Hansford; Marianne Phillips; Catherine Cole; Joshua Francis; Christopher C Blyth; Nicholas G Gottardo
Journal:  J Pediatr Hematol Oncol       Date:  2014-04       Impact factor: 1.289

3.  Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children.

Authors:  Caroline Diorio; Pamela A Shaw; Edward Pequignot; Alena Orlenko; Fang Chen; Richard Aplenc; David M Barrett; Hamid Bassiri; Edward Behrens; Amanda M DiNofia; Vanessa Gonzalez; Natalka Koterba; Bruce L Levine; Shannon L Maude; Nuala J Meyer; Jason H Moore; Michele Paessler; David L Porter; Jenny L Bush; Don L Siegel; Megan M Davis; Donglan Zhang; Carl H June; Stephan A Grupp; J Joseph Melenhorst; Simon F Lacey; Scott L Weiss; David T Teachey
Journal:  Blood Adv       Date:  2020-10-27

4.  Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients.

Authors:  Kazusa Ishii; Marie Pouzolles; Christopher D Chien; Rebecca A Erwin-Cohen; M Eric Kohler; Haiying Qin; Haiyan Lei; Skyler Kuhn; Amanda K Ombrello; Alina Dulau-Florea; Michael A Eckhaus; Haneen Shalabi; Bonnie Yates; Daniel A Lichtenstein; Valérie S Zimmermann; Taisuke Kondo; Jack F Shern; Howard A Young; Naomi Taylor; Nirali N Shah; Terry J Fry
Journal:  J Clin Invest       Date:  2020-10-01       Impact factor: 14.808

5.  FDA Approval Summary: Tisagenlecleucel for Treatment of Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia.

Authors:  Maura C O'Leary; Xiaobin Lu; Ying Huang; Xue Lin; Iftekhar Mahmood; Donna Przepiorka; Denise Gavin; Shiowjen Lee; Ke Liu; Bindu George; Wilson Bryan; Marc R Theoret; Richard Pazdur
Journal:  Clin Cancer Res       Date:  2018-10-11       Impact factor: 12.531

Review 6.  ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells.

Authors:  Daniel W Lee; Bianca D Santomasso; Frederick L Locke; Armin Ghobadi; Cameron J Turtle; Jennifer N Brudno; Marcela V Maus; Jae H Park; Elena Mead; Steven Pavletic; William Y Go; Lamis Eldjerou; Rebecca A Gardner; Noelle Frey; Kevin J Curran; Karl Peggs; Marcelo Pasquini; John F DiPersio; Marcel R M van den Brink; Krishna V Komanduri; Stephan A Grupp; Sattva S Neelapu
Journal:  Biol Blood Marrow Transplant       Date:  2018-12-25       Impact factor: 5.742

7.  Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial.

Authors:  Bita Shakoory; Joseph A Carcillo; W Winn Chatham; Richard L Amdur; Huaqing Zhao; Charles A Dinarello; Randall Q Cron; Steven M Opal
Journal:  Crit Care Med       Date:  2016-02       Impact factor: 7.598

8.  Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial.

Authors:  Stephan Kadauke; Regina M Myers; Yimei Li; Richard Aplenc; Diane Baniewicz; David M Barrett; Allison Barz Leahy; Colleen Callahan; Joseph G Dolan; Julie C Fitzgerald; Whitney Gladney; Simon F Lacey; Hongyan Liu; Shannon L Maude; Regina McGuire; Laura S Motley; David T Teachey; Gerald B Wertheim; Lisa Wray; Amanda M DiNofia; Stephan A Grupp
Journal:  J Clin Oncol       Date:  2021-01-08       Impact factor: 44.544

Review 9.  Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis.

Authors:  Eleni Karakike; Evangelos J Giamarellos-Bourboulis
Journal:  Front Immunol       Date:  2019-01-31       Impact factor: 7.561

10.  Cytokine Release Syndrome Grade as a Predictive Marker for Infections in Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Treated With Chimeric Antigen Receptor T Cells.

Authors:  Jae H Park; F Andres Romero; Ying Taur; Michel Sadelain; Renier J Brentjens; Tobias M Hohl; Susan K Seo
Journal:  Clin Infect Dis       Date:  2018-08-01       Impact factor: 9.079
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  3 in total

Review 1.  Infectious complications of CAR T-cell therapy across novel antigen targets in the first 30 days.

Authors:  Lekha Mikkilineni; Bonnie Yates; Seth M Steinberg; Shilpa A Shahani; John C Molina; Tara Palmore; Daniel W Lee; Rosandra N Kaplan; Crystal L Mackall; Terry J Fry; Juan Gea-Banacloche; Theresa Jerussi; Veronique Nussenblatt; James N Kochenderfer; Nirali N Shah
Journal:  Blood Adv       Date:  2021-12-14

2.  Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells.

Authors:  Daniel A Lichtenstein; Fiorella Schischlik; Lipei Shao; Seth M Steinberg; Bonnie Yates; Hao-Wei Wang; Yanyu Wang; Jon Inglefield; Alina Dulau-Florea; Francesco Ceppi; Leandro C Hermida; Kate Stringaris; Kim Dunham; Philip Homan; Parthav Jailwala; Justin Mirazee; Welles Robinson; Karen M Chisholm; Constance Yuan; Maryalice Stetler-Stevenson; Amanda K Ombrello; Jianjian Jin; Terry J Fry; Naomi Taylor; Steven L Highfill; Ping Jin; Rebecca A Gardner; Haneen Shalabi; Eytan Ruppin; David F Stroncek; Nirali N Shah
Journal:  Blood       Date:  2021-12-16       Impact factor: 22.113

Review 3.  Cytokine Release Syndrome and Associated Acute Toxicities in Pediatric Patients Undergoing Immune Effector Cell Therapy or Hematopoietic Cell Transplantation.

Authors:  Susanne H C Baumeister; Gopi S Mohan; Alaa Elhaddad; Leslie Lehmann
Journal:  Front Oncol       Date:  2022-03-24       Impact factor: 6.244
  3 in total

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