Kenichiro Miura1, Taro Ando1, Shoichiro Kanda1,2, Taeko Hashimoto1,3, Naoto Kaneko1, Kiyonobu Ishizuka1, Riku Hamada4, Hiroshi Hataya4, Kiyohiko Hotta5, Yoshimitsu Gotoh6, Kei Nishiyama7, Yuko Hamasaki8, Seiichiro Shishido8, Naoya Fujita9, Motoshi Hattori1. 1. Department of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan. 2. Department of Pediatrics, The University of Tokyo, Tokyo, Japan. 3. Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan. 4. Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. 5. Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 6. Department of Pediatric Nephrology, Japanese Red Cross Nagoya Daini Hospital, Aichi, Japan. 7. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 8. Department of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan. 9. Department of Nephrology, Aichi Children's Health and Medical Center, Aichi, Japan.
Abstract
BACKGROUND: Recurrence of SRNS is a major challenge in KT. Several clinical factors, including initial steroid sensitivity, have been associated with increased post-transplant SRNS recurrence risk. However, conflicting data have been reported, possibly due to the heterogeneous pathophysiology of SRNS and the lack of genetic testing of SRNS patients. Furthermore, the response to immunosuppressive therapies has not been evaluated. METHODS: Seventy patients aged 1-15 years at SRNS onset who underwent KT between 2002 and 2018 were enrolled. Patients with secondary, familial, syndromic, and genetic forms of SRNS and those who were not treated with steroid were excluded. This study aimed to assess the risk factors for post-transplant recurrence, including treatment responses to initial steroid therapy and additional therapies with immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A. RESULTS: Data from 36 kidney transplant recipients were analyzed. Twenty-two (61%) patients experienced post-transplant SRNS recurrence, while 14 patients did not. The proportion of patients who achieved complete or partial remission with initial steroid therapy and/or additional therapies with immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A was significantly higher in the SRNS recurrence group (19/22, 86%) than in the group without SRNS recurrence (6/14, 43%; p = .01). CONCLUSION: This study suggests that the response to steroid treatment, other immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A may predict post-transplant SRNS recurrence.
BACKGROUND: Recurrence of SRNS is a major challenge in KT. Several clinical factors, including initial steroid sensitivity, have been associated with increased post-transplant SRNS recurrence risk. However, conflicting data have been reported, possibly due to the heterogeneous pathophysiology of SRNS and the lack of genetic testing of SRNS patients. Furthermore, the response to immunosuppressive therapies has not been evaluated. METHODS: Seventy patients aged 1-15 years at SRNS onset who underwent KT between 2002 and 2018 were enrolled. Patients with secondary, familial, syndromic, and genetic forms of SRNS and those who were not treated with steroid were excluded. This study aimed to assess the risk factors for post-transplant recurrence, including treatment responses to initial steroid therapy and additional therapies with immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A. RESULTS: Data from 36 kidney transplant recipients were analyzed. Twenty-two (61%) patients experienced post-transplant SRNS recurrence, while 14 patients did not. The proportion of patients who achieved complete or partial remission with initial steroid therapy and/or additional therapies with immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A was significantly higher in the SRNS recurrence group (19/22, 86%) than in the group without SRNS recurrence (6/14, 43%; p = .01). CONCLUSION: This study suggests that the response to steroid treatment, other immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A may predict post-transplant SRNS recurrence.