| Literature DB >> 34308117 |
Louise Walker1,2, Natalie Smith1, Christine Delon3.
Abstract
BACKGROUND: Obesity is a risk factor for complications from SARS-CoV-2 infection, increasing the need for effective weight management measures in primary care. However, in the UK, COVID-19 restrictions have hampered primary care weight management referral and delivery, and COVID-19 related weight gain has been reported. The present study evaluated outcomes from a multicomponent weight loss and health promotion programme in UK primary care, delivered remotely due to COVID-19 restrictions.Entities:
Keywords: blood pressure lowering; dietary patterns; mental health; metabolic syndrome; weight management
Year: 2021 PMID: 34308117 PMCID: PMC7887868 DOI: 10.1136/bmjnph-2020-000219
Source DB: PubMed Journal: BMJ Nutr Prev Health ISSN: 2516-5542
Figure 1Flow of participants through the programme.
Participant characteristics at baseline and reasons for registration
| N (%) | |
| Participants | 20 (100) |
| Female | 17 (85) |
| Male | 3 (15) |
| Glycaemic status | |
| T2D (HbA1c ≥48.0 mmol/mol) | 10 (50) |
| Pre-diabetes (HbA1c 42.0–47.9 mmol/mol) | 1 (5) |
| Normal/unmeasured | 9 (45) |
| Weight status | |
| Obese (BMI ≥30.0 kg/m2) | 12 (60) |
| Overweight (BMI 25.0–29.9 kg/m2) | 5 (25) |
| Normal weight (BMI 18.5–24.9 kg/m2) | 3 (15) |
| Age group in years | |
| 40–49 | 4 (20) |
| 50–59 | 4 (20) |
| 60–69 | 5 (25) |
| ≥70 | 7 (35) |
| Reason(s) for registration | |
| Weight loss | 20 (100) |
| Improved glycaemic control | 12 (60) |
| Reversal of pre-diabetes (only one was pre-diabetic) | 2 (10) |
| To support a family member | 3 (15) |
BMI, body mass index; T2D, type 2 diabetes.
Outcomes for weight status, blood pressure and well-being
| Matched pairs, n | Baseline mean | 10 weeks mean | Change mean | Change median (IQR) | P value | |
| Body weight (kg) | 20 | 90.7 | 84.9 | −5.8 | −5.4 (−6.9 to −4.4) | <0.001 |
| Percent weight loss (%) | 20 | – | 6.5 | – | 6.5 (4.5 to 8.2) | – |
| BMI (kg/m2) | 20 | 32.1 | 30.0 | −2.0 | −2.0 (−2.5 to −1.5) | <0.001 |
| Waist circumference (cm) | 11 | 101.3 | 96.1 | −5.2 | −5.1 (−7.3 to −3.8) | 0.006 |
| HbA1c (mmol/mol) | 7 | 54.6 | 45.4 | −9.1 | −11.0 (−13.0 to −4.5) | 0.059 |
| Blood pressure | ||||||
| Systolic (mm Hg) | 7 | 130.6 | 117.4 | 13.1 | −14.0 (−19.5 to −9.5) | 0.035 |
| Diastolic (mm Hg) | 7 | 77.9 | 72.9 | 5.0 | 4.0 (−6.5 to −2.0) | 0.042 |
| Mental well-being | ||||||
| WEMWBS score | 17 | 45.2 | 51.7 | 6.5 | 7.0 (3.0 to 10.0) | 0.001 |
Data are only shown for participants who supplied data at baseline and 10 weeks (matched pairs).
BMI, body mass index; IQR, interquartile range (25th percentile, 75th percentile); WEMWBS, Warwick Edinburgh Mental Wellbeing Scale.
Figure 2Box and whisker charts showing baseline and 10-week distributions of patient data. The box represents the median value and the IQR, the red dot indicates the mean value and the upper and lower whiskers indicate either the minimum/maximum value or 1.5 times the IQR (outliers are not shown). Blue dotted line in figure part B denotes BMI range 18.5–25.0 kg/m2. BMI, body mass index.
Figure 3Initial HbA1c versus HbA1c within 1 month of programme end. The blue dashed line represents no change in HbA1c. Points above this line represent participants with an increased HbA1c; points on this line represent those with no change; and points below this line represent participants with reductions in HbA1c. The black solid line is the line of best fit for linear regression of final HbA1c with respect to starting HbA1c. The green dot-dashed lines represent an HbA1c of 48 mmol/mol.
Summary of subjective results from participant feedback survey
| N (%) | ||
| ‘Yes’ | ‘Somewhat’ | |
| Lost weight without hunger | 12 (67) | 5 (28) |
| Health and well-being had improved | 16 (89) | 2 (11) |
| Skin had improved | 5 (28) | 5 (28) |
| Food cravings had reduced | 12 (67) | 5 (28) |
| Better energy and vitality | 4 (22) | 13 (72) |
| Less ‘brain fog’/clearer thinking | 2 (11) | 5 (28) |
| Better sleep | 4 (22) | 6 (33) |
| Lower stress levels | 2 (11) | 9 (50) |
| Gained confidence in making good decisions about their health | 12 (67) | 6 (33) |
| Gained confidence and/or hope that they can improve their health | 15 (83) | 2 (11) |