Mahmood Tavakkoli1, Saeed Aali2, Borzoo Khaledifar3, Gordon A Ferns4, Majid Khazaei5, Kiavash Fekri6, Mohammad-Hassan Arjmand6. 1. Kidney Transplantation Complications Research Center, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Department of Urology, Kashani Academic Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran. 3. Department of Surgery, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. 4. Brighton & Sussex Medical School, Division of Medical Education, Brighton, United Kingdom. 5. Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Abstract
BACKGROUND: Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal obstruction, and increased mortality. The most important molecular mechanisms for the development of PSAB are inflammatory response, oxidative stress, and overexpression of pro-fibrotic molecules such as transforming growth factor β. However, questions remain about the pathogenesis of this problem, for example, the causes for individual differences or why certain tissue sites are more prone to post-surgical adhesions. SUMMARY: Addressing the pathological causes of PSAB, the potential role of local angiotensin II/angiotensin II type 1 receptors (AngII/AT1R), may help to prevent this problem. KEY MESSAGE: The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.
BACKGROUND: Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal obstruction, and increased mortality. The most important molecular mechanisms for the development of PSAB are inflammatory response, oxidative stress, and overexpression of pro-fibrotic molecules such as transforming growth factor β. However, questions remain about the pathogenesis of this problem, for example, the causes for individual differences or why certain tissue sites are more prone to post-surgical adhesions. SUMMARY: Addressing the pathological causes of PSAB, the potential role of local angiotensin II/angiotensin II type 1 receptors (AngII/AT1R), may help to prevent this problem. KEY MESSAGE: The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.
Authors: Anna Dikalova; Roza Clempus; Bernard Lassègue; Guangjie Cheng; James McCoy; Sergey Dikalov; Alejandra San Martin; Alicia Lyle; David S Weber; Daiana Weiss; W Robert Taylor; Harald H H W Schmidt; Gary K Owens; J David Lambeth; Kathy K Griendling Journal: Circulation Date: 2005-10-17 Impact factor: 29.690
Authors: Ramon Bataller; Robert F Schwabe; Youkyung H Choi; Liu Yang; Yong Han Paik; Jeffrey Lindquist; Ting Qian; Robert Schoonhoven; Curt H Hagedorn; John J Lemasters; David A Brenner Journal: J Clin Invest Date: 2003-11 Impact factor: 14.808