Francesca Zotti1, Riccardo Nocini2, Giorgia Capocasale3, Dario Bertossi4, Andrea Fior5, Martina Peretti6, Erminia Manfrin7, Massimo Albanese4. 1. Researcher, DDS, PhD, Department of Surgical Sciences, Paediatrics and Gynaecology, University of Verona. Policlinico G. B. Rossi, Piazzale L. Scuro n.10, 37134, Verona, Italy. 2. Resident, MD, Department of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Verona, Piazzale Aristide Stefani, n.1, 37126, Verona, Italy. 3. Resident, DDS, PhD, Department of Surgical Sciences, Paediatrics and Gynaecology, University of Verona. Policlinico G. B. Rossi, Piazzale L. Scuro n.10, 37134, Verona, Italy. 4. Associate professor, MD, MS, Department of Surgical Sciences, Paediatrics and Gynaecology, University of Verona. Policlinico G. B. Rossi, Piazzale L. Scuro n.10, 37134, Verona, Italy. 5. MD, MS, Unit of Dentistry and Maxillofacial Surgery, University Hospital of Verona, Italy. 6. Dental Hygienist, Private Practice, Verona, Italy. 7. Researcher, MD, MS, Department of Diagnostic and Public Health, University of Verona, Policlinico G. B. Rossi, Piazzale L. Scuro n.10, 37134, Verona, Italy.
Abstract
BACKGROUND: Oral Lichen Planus (OLP) is an inflammatory chronic disease. Modified World Health Organization (WHO) diagnostic criteria (2003) suggest diagnosing OLP both clinically and histologically. Furthermore, it is known the potential of malignant transformation of OLP, especially those affecting mucosa. Aims of this retrospective study on 100 patients were i) to estimate the timing of transformation of OLP lesions in OSCC in a cohort of patients observed between 2008 and 2018; ii) to assess risk factors of OLP patients diagnosed with OSCC; iii) to analyse forms of OLP evolved in cancer. MATERIAL AND METHODS: A database of 100 patients diagnosed with OLP was evaluated and clinical, histological features of lesions, habits of patients and systemic diseases were analysed in a follow up ranged between 5 and 10 years. RESULTS: Mean time of malignant transformation was 31,62± 18,26 months; however, 4 malignant transformations out of 8 occurred about after 4 years of observation. Furthermore, Odds ratios for risk factors showed an association between malignant transformation and location. CONCLUSIONS: More focused attention on follow-up scheduling and designing could be a valuable resource in early diagnosis and cancer prevention in OLP patients. Key words:Oral Lichen Planus, Oral Cancer, Malignant transformation, risk factors. Copyright:
BACKGROUND: Oral Lichen Planus (OLP) is an inflammatory chronic disease. Modified World Health Organization (WHO) diagnostic criteria (2003) suggest diagnosing OLP both clinically and histologically. Furthermore, it is known the potential of malignant transformation of OLP, especially those affecting mucosa. Aims of this retrospective study on 100 patients were i) to estimate the timing of transformation of OLP lesions in OSCC in a cohort of patients observed between 2008 and 2018; ii) to assess risk factors of OLP patients diagnosed with OSCC; iii) to analyse forms of OLP evolved in cancer. MATERIAL AND METHODS: A database of 100 patients diagnosed with OLP was evaluated and clinical, histological features of lesions, habits of patients and systemic diseases were analysed in a follow up ranged between 5 and 10 years. RESULTS: Mean time of malignant transformation was 31,62± 18,26 months; however, 4 malignant transformations out of 8 occurred about after 4 years of observation. Furthermore, Odds ratios for risk factors showed an association between malignant transformation and location. CONCLUSIONS: More focused attention on follow-up scheduling and designing could be a valuable resource in early diagnosis and cancer prevention in OLP patients. Key words:Oral Lichen Planus, Oral Cancer, Malignant transformation, risk factors. Copyright:
Authors: Michael M Bornstein; Lucie Kalas; Sandra Lemp; Hans Jörg Altermatt; Terry D Rees; Daniel Buser Journal: Quintessence Int Date: 2006-04 Impact factor: 1.677