Yan Li1,2, Zhi Xu1,2, Cuo Qing1,2, Hong Zhang1,2, Xia Wu1,2, Jilu Yang1,2. 1. Department of Respiratory and Critical Care Medicine, The 3rd Affiliated Hospital of Chengdu Medical College Chengdu 611700, Sichuang Province, China. 2. Pidu District People's Hospital Chengdu 611700, Sichuang Province, China.
Abstract
BACKGROUND: To investigate the efficacy of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). METHODS:248 patients with AECOPD were assigned into two groups, 124 patients in the control group were only given terbutaline treatment, while 124 patients in the experimental group were treated with glucocorticoid and terbutaline. The effect on lung function and blood gas indexes were compared between the two groups. RESULTS: The total effective rate of the treatment with glucocorticoid and terbutaline was higher than that of control group (P < 0.05). After treatment, the pulmonary function indexes such as FEV1, FVC and PaO2 levels in the two groups were significantly higher than those before treatment, PaCO2 levels were significantly lower than that before the treatment (P < 0.05). CONCLUSIONS: The combined use of glucocorticoid and terbutaline could effectively improve the lung function and blood gas indexes. It's of great significance to promote the rehabilitation of patients with AECOPD, and it provides insights for future clinical practice. AJTR
RCT Entities:
BACKGROUND: To investigate the efficacy of glucocorticoid and terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). METHODS: 248 patients with AECOPD were assigned into two groups, 124 patients in the control group were only given terbutaline treatment, while 124 patients in the experimental group were treated with glucocorticoid and terbutaline. The effect on lung function and blood gas indexes were compared between the two groups. RESULTS: The total effective rate of the treatment with glucocorticoid and terbutaline was higher than that of control group (P < 0.05). After treatment, the pulmonary function indexes such as FEV1, FVC and PaO2 levels in the two groups were significantly higher than those before treatment, PaCO2 levels were significantly lower than that before the treatment (P < 0.05). CONCLUSIONS: The combined use of glucocorticoid and terbutaline could effectively improve the lung function and blood gas indexes. It's of great significance to promote the rehabilitation of patients with AECOPD, and it provides insights for future clinical practice. AJTR
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