INTRODUCTION: The aim of this study was to systematically review the literature regarding accurate shoulder prosthetic joint infection (PJI) diagnosis. METHODS: Using PRISMA guidelines, we analyzed 25 studies reporting on 5535 patients and 646 infections. RESULTS: Cutibacterium acnes (C. acnes) cultures were positive in 60% of patients. Serum markers WBC, CRP, ESR, and IL-6 appear to lack diagnostic reliability. Synovial IL-6 and alpha-defensin may be more accurate in detecting infections. CONCLUSION: Synovial IL-6 and alpha-defensin appear to have greater utility than serum markers. These may be incorporated into new criteria to accurately diagnose shoulder PJI. LEVEL OF EVIDENCE: IV.
INTRODUCTION: The aim of this study was to systematically review the literature regarding accurate shoulder prosthetic joint infection (PJI) diagnosis. METHODS: Using PRISMA guidelines, we analyzed 25 studies reporting on 5535 patients and 646 infections. RESULTS: Cutibacterium acnes (C. acnes) cultures were positive in 60% of patients. Serum markers WBC, CRP, ESR, and IL-6 appear to lack diagnostic reliability. Synovial IL-6 and alpha-defensin may be more accurate in detecting infections. CONCLUSION: Synovial IL-6 and alpha-defensin appear to have greater utility than serum markers. These may be incorporated into new criteria to accurately diagnose shoulder PJI. LEVEL OF EVIDENCE: IV.
Authors: Gregory N Nelson; E Scott Paxton; Alexa Narzikul; Gerald Williams; Mark D Lazarus; Joseph A Abboud Journal: J Shoulder Elbow Surg Date: 2015-09 Impact factor: 3.019
Authors: Paul Pottinger; Susan Butler-Wu; Moni Blazej Neradilek; Andrew Merritt; Alexander Bertelsen; Jocelyn L Jette; Winston J Warme; Frederick A Matsen Journal: J Bone Joint Surg Am Date: 2012-11-21 Impact factor: 5.284
Authors: Thomas Falstie-Jensen; Henrik Daugaard; Kjeld Søballe; Janne Ovesen; Anne Kirstine Arveschoug; Jeppe Lange Journal: J Shoulder Elbow Surg Date: 2019-01-31 Impact factor: 3.019
Authors: Andreas Hecker; Anna Jungwirth-Weinberger; Michael Robert Bauer; Timo Tondelli; Ilker Uçkay; Karl Wieser Journal: J Shoulder Elbow Surg Date: 2019-09-25 Impact factor: 3.019
Authors: Hans Gollwitzer; Yvonne Dombrowski; Peter M Prodinger; Mark Peric; Burkhard Summer; Alexander Hapfelmeier; Belma Saldamli; Felix Pankow; Rüdiger von Eisenhart-Rothe; Andreas B Imhoff; Jürgen Schauber; Peter Thomas; Rainer Burgkart; Ingo J Banke Journal: J Bone Joint Surg Am Date: 2013-04-03 Impact factor: 5.284
Authors: Carl Deirmengian; Keith Kardos; Patrick Kilmartin; Alexander Cameron; Kevin Schiller; Javad Parvizi Journal: Clin Orthop Relat Res Date: 2014-11 Impact factor: 4.176
Authors: Paola Bermudez-Lekerika; Katherine B Crump; Sofia Tseranidou; Andrea Nüesch; Exarchos Kanelis; Ahmad Alminnawi; Laura Baumgartner; Estefano Muñoz-Moya; Roger Compte; Francesco Gualdi; Leonidas G Alexopoulos; Liesbet Geris; Karin Wuertz-Kozak; Christine L Le Maitre; Jérôme Noailly; Benjamin Gantenbein Journal: Front Cell Dev Biol Date: 2022-06-29
Authors: Laura Elisa Streck; Chiara Gaal; Johannes Forster; Christian Konrads; Sebastian Philipp von Hertzberg-Boelch; Kilian Rueckl Journal: J Clin Med Date: 2021-12-23 Impact factor: 4.241