Holly Foot1, Ian Scott2, Nancy Sturman3, Jennifer A Whitty4, Kylie Rixon5, Luke Connelly6, Ian Williams3, Christopher Freeman7. 1. School of Pharmacy, The University of Queensland, Woolloongabba, Australia. Electronic address: h.ross1@uq.edu.au. 2. Department of Internal Medicine and Clinical Epidemiology, Princess Alexandra Hospital, Woolloongabba, Australia; School of Clinical Medicine, The University of Queensland, Brisbane, Australia. 3. Primary Care Clinical Unit, Faculty of Medicine, The University of Queensland, Brisbane, Australia. 4. School of Pharmacy, The University of Queensland, Woolloongabba, Australia; Health Economics Group, Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom; NIHR Applied Research Collaboration (ARC), East of England, United Kingdom. 5. Griffith University, Mt Nathan, Australia. 6. Centre for the Business and Economics of Health, Faculty of Business, Economics and Law, The University of Queensland, Woolloongabba, Australia; School of Sociology and Business Law, The University of Bologna, Bologna, Italy. 7. School of Pharmacy, The University of Queensland, Woolloongabba, Australia.
Abstract
BACKGROUND: Readmissions to hospital due to medication-related problems are common and may be preventable. Pharmacists act to optimise use of medicines during care transitions from hospital to community. OBJECTIVE: To assess the impact of pharmacist-led interventions, which include communication with a primary care physician (PCP) on reducing hospital readmissions. METHODS: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL and Web of Science were searched for articles published from inception to March 2021 that described interventions involving a pharmacist interacting with a PCP in regards to medication management of patients recently discharged from hospital. The primary outcome was effect on all-cause readmission expressed as Mantel-Haenszel risk ratio (RR) derived from applying a random effects model to pooled data. Sensitivity analysis was also conducted to investigate differences between randomised controlled trials (RCTs) and non-RCTs. The GRADE system was applied in rating the quality of evidence and certainty in the estimates of effect. RESULTS: In total, 37 studies were included (16 RCTs and 29 non-RCTs). Compared to control patients, the proportion of intervention patients readmitted at least once was significantly reduced by 13% (RR = 0.87, CI:0.79-0.97, p = 0.01; low to very low certainty of evidence) over follow-up periods of variable duration in all studies combined, and by 22% (RR = 0.78, CI:0.67-0.92; low certainty of evidence) at 30 day follow-up across studies reporting this time point. Analysis of data from RCTs only showed no significant reduction in readmissions (RR = 0.92, CI:0.80-1.06; low certainty of evidence). CONCLUSIONS: The totality of evidence suggests pharmacist-led interventions with PCP communication are effective in reducing readmissions, especially at 30 days follow-up. Future studies need to adopt more rigorous study designs and apply well-defined patient eligibility criteria.
BACKGROUND: Readmissions to hospital due to medication-related problems are common and may be preventable. Pharmacists act to optimise use of medicines during care transitions from hospital to community. OBJECTIVE: To assess the impact of pharmacist-led interventions, which include communication with a primary care physician (PCP) on reducing hospital readmissions. METHODS: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL and Web of Science were searched for articles published from inception to March 2021 that described interventions involving a pharmacist interacting with a PCP in regards to medication management of patients recently discharged from hospital. The primary outcome was effect on all-cause readmission expressed as Mantel-Haenszel risk ratio (RR) derived from applying a random effects model to pooled data. Sensitivity analysis was also conducted to investigate differences between randomised controlled trials (RCTs) and non-RCTs. The GRADE system was applied in rating the quality of evidence and certainty in the estimates of effect. RESULTS: In total, 37 studies were included (16 RCTs and 29 non-RCTs). Compared to control patients, the proportion of intervention patients readmitted at least once was significantly reduced by 13% (RR = 0.87, CI:0.79-0.97, p = 0.01; low to very low certainty of evidence) over follow-up periods of variable duration in all studies combined, and by 22% (RR = 0.78, CI:0.67-0.92; low certainty of evidence) at 30 day follow-up across studies reporting this time point. Analysis of data from RCTs only showed no significant reduction in readmissions (RR = 0.92, CI:0.80-1.06; low certainty of evidence). CONCLUSIONS: The totality of evidence suggests pharmacist-led interventions with PCP communication are effective in reducing readmissions, especially at 30 days follow-up. Future studies need to adopt more rigorous study designs and apply well-defined patient eligibility criteria.
Authors: Laura Victoria Jedig Lech; Charlotte Rossing; Trine Rune Høgh Andersen; Lotte Stig Nørgaard; Anna Birna Almarsdóttir Journal: Explor Res Clin Soc Pharm Date: 2022-09-05