Itraconazole Oral Solution for a Case of Infantile Hemangioma: Monitoring the Efficacy by Dermoscopy and MRI.

Infantile hemangioma is a common and challenging benign vascular tumor. Although involution is spontaneous, approximately 10% of infantile hemangioma of large size or in specific locations may cause ulceration, severe cosmetic and functional problems that may require intervention. Treatment options include oral propranolol, topical timolol, and oral corticosteroids. However, the clinical response is not always satisfactory. We report the case of a 4-month-old boy who presented with an irregular erythematous plaque on his left shoulder 3 days after birth. Infantile hemangioma was diagnosed. Topical application of 0.5 ml of 0.5% timolol maleate eye drops for half an hour each time three times a day was initiated. After nearly 3 months of follow-up, the size of the lesion gradually increased. Finally, after 115 days of treatment with itraconazole oral solution (the total dose was about 4025 mg), the refractory infantile hemangioma was successfully treated. Hepatic and renal function remained normal with only mild diarrhea during the course of oral medication. Treatment compliance of oral itraconazole in infants has been reported to be good. Dermoscopy and magnetic resonance imaging (MRI) played a crucial role in in vivo observation of the hemangioma changes with vascular regression during the treatment process.

Key Summary Points

Introduction

Infantile hemangioma (IH) is known as the most common benign vascular tumor of childhood. IH occurs more frequently in female infants, with 5–10% incidence during the first year of life [1], with prematurity, low birth weight, and placental anomalies appearing to be the most significant risk factors [2]. Their pathogenesis remains unknown. Since 2009, topical beta-blockers have been widely used in the clinical treatment of IH, among which 0.5% timolol maleate eye drops are commonly used [3]. Itraconazole (ICZ), an active triazole antifungal drug, has recently been found to possess antiangiogenic and anti-hedgehog activity. Our team had previously reported case series on the therapeutic effects of ICZ capsules on IH [4]. We herein report a case of ineffective topical application of timolol maleate eye drops treated successfully with ICZ oral solution. Dermoscopy and MRI may play a vital role in diagnosis and monitoring of treatment.

Case Presentation

A 4-month-old boy presented with an irregular erythematous plaque on his left shoulder 3 days after birth. The lesion gradually turned brighter, progressive, and enlarged into an elevated erythematous plaque. Clinical diagnosis was consistent with IH. Topical application of 0.5 ml of 0.5% timolol maleate eye drops for half an hour each time three times a day was initiated. After nearly 3 months of the treatment, the lesion became bigger. The infant was born full-term, weighing 3.9 kg without any complications. Physical examination revealed a nonblanchable erythematous plaque of approximately 2.6 × 2.4 cm size on the left shoulder (Fig. 1A1). Dermoscopic examination showed an intensive vascular network (Fig. 1B1). MRI examination accorded with the diagnosis of IH (Fig. 2A). The patient’s mother gave informed consent and was counseled about the benefits and possible adverse effects before initiating the treatment. The patient weighed 7 kg, and the daily dosage calculated at 5.0 mg/kg/day was 35 mg, equal to 3.5 ml ICZ oral solution (Sporanox) (Janssen, Xi’an, China). Using a syringe without a needle, 3.5 ml of the oral solution was withdrawn and fed orally to the child. The parents were provided a form to record the actual dosage and adverse reactions during the course of the treatment. After 115 days of treatment, the skin lesion turned flat and significantly reduced in size, and dermoscopic features showed distinct vascular network and fewer capillary branches (Fig. 1A2, B2), so the treatment was terminated. During the 1 month of follow-up, the lesion was almost cured, with only residual skin erythema left (Fig. 1A3, B3). MRI examination was rescheduled (Fig. 2B). Liver function examination was within normal limit, with only mild diarrhea, which did not affect the continued medication. Until the age of 16 months, no recurrence of hemangioma has been observed.

Fig. 1

Clinical response of a 4-month-old boy to oral ICZ solution therapy. Clinical manifestation of the patient observed for the first time (A1, B1). After 115 days of treatment, the lesion significantly improved, the intensive vascular network gradually disappeared during the treatment (amplification ×67) (A2, B2). The latest follow-up showed no recurrence of hemangioma (A3, B3)

Fig. 2

Time course of the IH changes of MRI monitoring during ICZ oral solution therapy corresponding to the observation of the targets. At the beginning of the treatment: transverse T2-weighted A images show a mass (arrow) sized 2.2 × 2.8 × 0.7 cm in the lateral aspect of the left upper arm. The latest follow-up: transverse T2-weighted B images reveal the size of mass has shrunk to about 1.5 × 2.2 × 0.7 cm

Discussion

IH usually forms within the first week after birth and grows rapidly during the first 3–6 months, known as the proliferating phase of IH. Subsequently, spontaneous regression occurs from 12 months to 5 years of age and beyond [5-7]. IH may require intervention owing to serious cosmetic and functional problems. Propranolol is regarded as the first-line treatment for IH. However, the treatment with oral propranolol requires monitoring the blood pressure and heart rate in the first 3 days, leading to low compliance of outpatients. This therapy has not reached significant results in about 10% of patients, as a result of regrowth, slow improvement, or failure [8, 9]. ICZ has been used as a safe clinical agent to treat broad-spectrum fungal infections more than 30 years [10]. Researchers have studied the mechanism of its inhibition of angiogenesis [11, 12]. In 2015, the effect of ICZ capsule on IH was suddenly discovered by our team, resulting in better clinical outcomes in six cases [4]. We found that ICZ induces regression of infantile IH via downregulation of the platelet-derived growth factor-D/PI3K/Akt/mTOR pathway [13].

In our case, the patient’s parents had a strong desire for treatment. After an ineffective treatment outcome with topical application of timolol maleate eye drops for nearly 3 months, he was brought to our hospital. After 1 month, the lesion achieved partial efficacy and almost resolved with remaining skin erythema after nearly 4 months of treatment with ICZ oral solution. Hepatic and renal function remained normal, with only mild diarrhea during the course of oral medication. The infant may be in the proliferative period during treatment with ICZ. Clinical images showed dramatic improvement following ICZ therapy, which is unlikely due to spontaneous resolution alone. It is convenient to examine liver function before and after treatment with ICZ. Infants may have difficulty swallowing capsules. Furthermore, adjusting the dosages of capsules for children can prove troublesome. One milliliter of ICZ oral solution contains 10 mg of ICZ, which is more accurately measured on the syringe and more convenient than splitting capsule particles. In addition, its cherry flavor makes it more acceptable to infants. Treatment compliance of oral ICZ in infants has been reported to be good. Neither this boy in this case nor the infants in the previous case series reported by our team currently show recurrence of hemangioma. Due to limited data, more clinical trials are needed to be conducted for confirmation. Oral ICZ can be used as a supplementary treatment for IH.

Compared with the naked eye, dermoscopy can observe subtle changes before and after treatment more clearly by adjusting the magnification. At present, there are only a few reports about the dermoscopic characteristics of IH. Meanwhile, MRI can provide additional information, such as the extent of the lesion. Several studies have reported on the imaging features of IH on conventional MRI [14, 15].

Conclusion

ICZ oral solution can be used as a novel drug for refractory IH that failed to respond to topical application of timolol maleate eye drops. Dermoscopy and MRI are combined with monitoring the vascular regression of ICZ oral solution before and after the treatment of IH for effective therapeutic evaluation.

A 4-month-old boy presented with an irregular erythematous plaque on his left shoulder 3 days after birth. Infantile hemangioma was diagnosed. We report a case failure to topical application of timolol maleate eye drops successfully treated by itraconazole oral solution.

Due to the high compliance of infants during the treatment, oral itraconazole played an effective complementary therapy to serve infantile hemangioma.

Dermoscopy played a crucial role in in vivo accurate observation of the hemangioma changes with vascular regression during the treatment process. MRI played a vital role in diagnosis and monitoring of the therapeutic process.