| Literature DB >> 34301958 |
Dashuai Zhu1,2, Jingli Hou3, Meng Qian1, Dawei Jin4, Tian Hao1, Yanjun Pan4, He Wang1, Shuting Wu4, Shuo Liu2, Fei Wang1, Lanping Wu5, Yumin Zhong6, Zhilu Yang7, Yongzhe Che2, Jie Shen8, Deling Kong1, Meng Yin9, Qiang Zhao10,11.
Abstract
Nitric oxide (NO) is a short-lived signaling molecule that plays a pivotal role in cardiovascular system. Organic nitrates represent a class of NO-donating drugs for treating coronary artery diseases, acting through the vasodilation of systemic vasculature that often leads to adverse effects. Herein, we design a nitrate-functionalized patch, wherein the nitrate pharmacological functional groups are covalently bound to biodegradable polymers, thus transforming small-molecule drugs into therapeutic biomaterials. When implanted onto the myocardium, the patch releases NO locally through a stepwise biotransformation, and NO generation is remarkably enhanced in infarcted myocardium because of the ischemic microenvironment, which gives rise to mitochondrial-targeted cardioprotection as well as enhanced cardiac repair. The therapeutic efficacy is further confirmed in a clinically relevant porcine model of myocardial infarction. All these results support the translational potential of this functional patch for treating ischemic heart disease by therapeutic mechanisms different from conventional organic nitrate drugs.Entities:
Year: 2021 PMID： 34301958 DOI： 10.1038/s41467-021-24804-3
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919