Saraa Abu-Melha1, Sobhi M Gomha2,3, Amr S Abouzied4,5, Mastoura M Edrees1,5, Ahmed S Abo Dena5,6, Zeinab A Muhammad5. 1. Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia. 2. Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt. 3. Chemistry Department, Faculty of Science, Islamic University in Almadinah Almonawara, Almadinah Almonawara 42351, Saudi Arabia. 4. Pharmaceutical Chemistry Department, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia. 5. Pharmaceutical Chemistry Department, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt. 6. Faculty of Oral and Dental Medicine, Future University in Egypt (FUE), New Cairo 11835, Egypt.
Abstract
Pyridazine and thiazole derivatives have various biological activities such as antimicrobial, analgesic, anticancer, anticonvulsant, antitubercular and other anticipated biological properties. Chitosan can be used as heterogeneous phase transfer basic biocatalyst in heterocyclic syntheses. Novel 1-thiazolyl-pyridazinedione derivatives were prepared via multicomponent synthesis under microwave irradiation as ecofriendly energy source and using the eco-friendly naturally occurring chitosan basic catalyst with high/efficient yields and short reaction time. All the prepared compounds were fully characterized by spectroscopic methods, and their in vitro biological activities were investigated. The obtained results were compared with those of standard antibacterial/antifungal agents. DFT calculations and molecular docking studies were used to investigate the electronic properties and molecular interactions with specific microbial receptors.
class="Chemical">Pyridazine and n class="Chemical">thiazole derivatives have various biological activities such as antimicrobial, analgesic, anticancer, anticonvulsant, antitubercular and other anticipated biological properties. Chitosan can be used as heterogeneous phase transfer basic biocatalyst in heterocyclic syntheses. Novel 1-thiazolyl-pyridazinedione derivatives were prepared via multicomponent synthesis under microwave irradiation as ecofriendly energy source and using the eco-friendly naturally occurring chitosan basic catalyst with high/efficient yields and short reaction time. All the prepared compounds were fully characterized by spectroscopic methods, and their in vitro biological activities were investigated. The obtained results were compared with those of standard antibacterial/antifungal agents. DFT calculations and molecular docking studies were used to investigate the electronic properties and molecular interactions with specific microbial receptors.
Authors: Khaled D Khalil; Hoda A Ahmed; Ali H Bashal; Stefan Bräse; AbdElAziz A Nayl; Sobhi M Gomha Journal: Polymers (Basel) Date: 2022-08-17 Impact factor: 4.967
Authors: Lais Cavalcanti Dos Santos Velasco de Souza; Lucas Martins Alcântara; Pãmella Antunes de Macêdo-Sales; Nathália Faria Reis; Débora Sena de Oliveira; Ricardo Luiz Dantas Machado; Reinaldo Barros Geraldo; André Luis Souza Dos Santos; Vítor Francisco Ferreira; Daniel Tadeu Gomes Gonzaga; Fernando de Carvalho da Silva; Helena Carla Castro; Andréa Regina de Souza Baptista Journal: Pharmaceuticals (Basel) Date: 2022-01-01