Valerio Nardone1,2, Luca Boldrini3, Roberta Grassi1,2, Davide Franceschini4, Ilaria Morelli5, Carlotta Becherini5, Mauro Loi6, Daniela Greto6, Isacco Desideri6,7. 1. Department of Precision Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy. 2. Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy. 3. Radiation Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy. 4. Radiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Milan, Italy. 5. Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy. 6. Radiation Oncology Unit, Azienda Ospedaliero Universitaria Careggi, 50139 Florence, Italy. 7. Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Abstract
INTRODUCTION: Neoadjuvant radiotherapy is currently used mainly in locally advanced rectal cancer and sarcoma and in a subset of non-small cell lung cancer and esophageal cancer, whereas in other diseases it is under investigation. The evaluation of the efficacy of the induction strategy is made possible by performing imaging investigations before and after the neoadjuvant therapy and is usually challenging. In the last decade, texture analysis (TA) has been developed to help the radiologist to quantify and identify the parameters related to tumor heterogeneity, which cannot be appreciated by the naked eye. The aim of this narrative is to review the impact of TA on the prediction of response to neoadjuvant radiotherapy and or chemoradiotherapy. MATERIALS AND METHODS: Key references were derived from a PubMed query. Hand searching and ClinicalTrials.gov were also used. RESULTS: This paper contains a narrative report and a critical discussion of radiomics approaches in different fields of neoadjuvant radiotherapy, including esophageal cancer, lung cancer, sarcoma, and rectal cancer. CONCLUSIONS: Radiomics can shed a light on the setting of neoadjuvant therapies that can be used to tailor subsequent approaches or even to avoid surgery in the future. At the same, these results need to be validated in prospective and multicenter trials.
INTRODUCTION: Neoadjuvant radiotherapy is currently used mainly in locally advanced rectal cancer and sarcoma and in a subset of non-small cell lung cancer and esophageal cancer, whereas in other diseases it is under investigation. The evaluation of the efficacy of the induction strategy is made possible by performing imaging investigations before and after the neoadjuvant therapy and is usually challenging. In the last decade, texture analysis (TA) has been developed to help the radiologist to quantify and identify the parameters related to tumor heterogeneity, which cannot be appreciated by the naked eye. The aim of this narrative is to review the impact of TA on the prediction of response to neoadjuvant radiotherapy and or chemoradiotherapy. MATERIALS AND METHODS: Key references were derived from a PubMed query. Hand searching and ClinicalTrials.gov were also used. RESULTS: This paper contains a narrative report and a critical discussion of radiomics approaches in different fields of neoadjuvant radiotherapy, including esophageal cancer, lung cancer, sarcoma, and rectal cancer. CONCLUSIONS: Radiomics can shed a light on the setting of neoadjuvant therapies that can be used to tailor subsequent approaches or even to avoid surgery in the future. At the same, these results need to be validated in prospective and multicenter trials.
Authors: Fabrizio Urraro; Valerio Nardone; Alfonso Reginelli; Carlo Varelli; Antonio Angrisani; Vittorio Patanè; Luca D'Ambrosio; Pietro Roccatagliata; Gaetano Maria Russo; Luigi Gallo; Marco De Chiara; Lucia Altucci; Salvatore Cappabianca Journal: Front Oncol Date: 2021-12-21 Impact factor: 6.244