P Naranjo-Bonilla1,2,3, María C Muñoz-Villanueva4, R Giménez-Gómez5,6, B Jurado-Gámez7,8. 1. Ophthalmology Department, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain. pedro.naranjo.bonilla@gmail.com. 2. Ophthalmology Department, Hospital Universitario Juan Ramón Jiménez, Huelva, Spain. pedro.naranjo.bonilla@gmail.com. 3. , Cordoba, Spain. pedro.naranjo.bonilla@gmail.com. 4. Primary Care Health Centre, Córdoba-Guadalquivir Health District, Cordoba, Spain. 5. Ophthalmology Department, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain. 6. Ophthalmology Department, Hospital Universitario Reina Sofía, Cordoba, Spain. 7. Respiratory Department, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain. 8. Respiratory Department, Hospital Universitario Reina Sofía, Cordoba, Spain.
Abstract
PURPOSE: To examine retinal and choroidal thicknesses in individuals with obstructive sleep apnea (OSA) and determine the impacts of continuous positive airway pressure (CPAP) treatment. METHODS: Prospective follow-up study conducted at a university hospital. 40 patients with OSA, 28 treated with CPAP, and 12 untreated, were enrolled immediately after diagnosis and graded according to the apnea hypopnea index (AHI) determined in an overnight polysomnography. Inclusion criteria were a new diagnosis of OSA and CPAP indicated. Participants underwent a full ophthalmologic examination including optical coherence tomography (OCT) at the peripapillary, macular, and choroidal levels and the same examination 3 months later. Outcome measures were peripapillary retinal nerve fiber layer (RNFL), total retinal (TRT), retinal ganglion cell layer (RGCL), inner plexiform layer (IPL), photoreceptor layer (PL), and choroidal thicknesses. RESULTS: At 3 months, RGCL thickness was reduced at the inner nasal macula segment in the no-CPAP group (P = 0.016). In + CPAP, increases were produced in RNFL thickness (5/6 segments) and TRT (7/ 9 segments), while choroidal thinning was observed temporally (P = 0.003). At baseline, positive correlation was detected between choroidal thickness and AHI (r = 0.352, P = 0.005) and between IPL thickness (7/9 segments) and AHI (r = 0.414, P < 0.001). CONCLUSIONS: Initial retinal and choroidal thickening was followed by RGCL thinning over 3 months. In patients receiving CPAP, we observed no thinning of any retinal layer and normalization of choroidal thickness.
PURPOSE: To examine retinal and choroidal thicknesses in individuals with obstructive sleep apnea (OSA) and determine the impacts of continuous positive airway pressure (CPAP) treatment. METHODS: Prospective follow-up study conducted at a university hospital. 40 patients with OSA, 28 treated with CPAP, and 12 untreated, were enrolled immediately after diagnosis and graded according to the apnea hypopnea index (AHI) determined in an overnight polysomnography. Inclusion criteria were a new diagnosis of OSA and CPAP indicated. Participants underwent a full ophthalmologic examination including optical coherence tomography (OCT) at the peripapillary, macular, and choroidal levels and the same examination 3 months later. Outcome measures were peripapillary retinal nerve fiber layer (RNFL), total retinal (TRT), retinal ganglion cell layer (RGCL), inner plexiform layer (IPL), photoreceptor layer (PL), and choroidal thicknesses. RESULTS: At 3 months, RGCL thickness was reduced at the inner nasal macula segment in the no-CPAP group (P = 0.016). In + CPAP, increases were produced in RNFL thickness (5/6 segments) and TRT (7/ 9 segments), while choroidal thinning was observed temporally (P = 0.003). At baseline, positive correlation was detected between choroidal thickness and AHI (r = 0.352, P = 0.005) and between IPL thickness (7/9 segments) and AHI (r = 0.414, P < 0.001). CONCLUSIONS: Initial retinal and choroidal thickening was followed by RGCL thinning over 3 months. In patients receiving CPAP, we observed no thinning of any retinal layer and normalization of choroidal thickness.
Authors: Patricia Lloberes; Joaquín Durán-Cantolla; Miguel Ángel Martínez-García; José María Marín; Antoni Ferrer; Jaime Corral; Juan Fernando Masa; Olga Parra; Mari Luz Alonso-Álvarez; Joaquín Terán-Santos Journal: Arch Bronconeumol Date: 2011-03 Impact factor: 4.872
Authors: Gloria Tejero-Garcés; Francisco J Ascaso; Paula Casas; Maria I Adiego; Peter Baptista; Carlos O'Connor-Reina; Eugenio Vicente; Guillermo Plaza Journal: J Clin Med Date: 2022-02-03 Impact factor: 4.241
Authors: Pedro Naranjo-Bonilla; Rafael Giménez-Gómez; María Del Carmen Muñoz-Villanueva; Bernabé Jurado-Gámez Journal: Int J Environ Res Public Health Date: 2022-10-03 Impact factor: 4.614