Video-assisted thoracoscopic surgery for primary lung cancer resections in patients with moderate to severe chronic obstructive pulmonary diseases.

BACKGROUND: Lung cancer patients with chronic obstructive pulmonary disease (COPD) are considered a high-risk population to receive radical surgical treatment due to the high incidence of cardiopulmonary complications. The aim of this study was to evaluate the clinical factors associated with postoperative complications in primary lung cancer patients with moderate to extremely severe grades of COPD.
METHODS: From December 2015 to June 2020, 138 patients with moderate to extremely severe COPD who underwent video-assisted thoracoscopic surgery (VATS) lung cancer resection (lobectomy or sublobar resection) were retrospectively reviewed. Patients' postoperative complications were collected from clinical records. Clinical factors (such as COPD severity or surgical approaches, etc.) were evaluated to investigate the association with postoperative complications.
RESULTS: Of the 138 patients included in the study, the mean age was 67 (63-74) years, the mean preoperative forced expiratory volume in one second (FEV1) was 1.33±0.39 L, the mean FEV1% was 51.23% (41.43-60.00%). 33% patients (46/138) had postoperative complications, and no mortality occurred. Univariate analysis revealed that incidence of overall complications (OCs) and respiratory complications (RCs) was markedly higher in extremely severe COPD patients compared to moderate (OCs, P=0.033; RCs, P=0.050) and severe (OCs, P=0.015; RCs, P=0.008) COPD patients, respectively. Multivariate analysis showed that COPD grade was an independent risk factor of RCs (P=0.024). Furthermore, the grades of COPD (moderate, P=0.029; severe, P=0.028; extremely severe, P=0.019) and the surgical procedure (lobectomy or sublobar resection, P=0.043) were independent risk factors for atelectasis, which was the most common postoperative complication.
CONCLUSIONS: The aggravation of COPD was accompanied by an increase in the incidence of respiratory system complications postoperatively, especially atelectasis. For patients with moderate to extremely severe grades of COPD, careful perioperative evaluation should be performed to identify the indicators that influence the surgical choice between lobectomy and sublobar resection. 2021 Translational Lung Cancer Research. All rights reserved.

Introduction

Lung cancer is the leading causes of death worldwide (1). Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation that lead to destruction of lung tissue and the long-term decline in lung function (2). Due to a chronic systemic, local inflammatory state and lung tissue remodeling, COPD patients have an increased risk of lung cancer (3). The incidence of lung cancer in COPD patients in the United States is as high as 16.7/1,000 cases per year (4). For these special subgroups of patients with co-occurring COPD and lung cancer—often referred to as severe lung cancer (5)—standardized inhalation therapy along with antitumor therapy may improve the quality of life and prognosis (6).

Although surgical resection is still the treatment of choice for patients with severe lung cancer, reduced lung function and insufficient respiratory reserve make these patients face a higher risk of surgery. The published standard indicators of inoperability include: baseline forced expiratory volume in 1 second (FEV1) less than 40% predicted, postoperative FEV1 less than 30% predicted, carbon monoxide diffusing capacity (DLCO) less than 40% predicted, baseline hypoxemia or hypercapnia, and severe pulmonary hypertension (7). The severity of COPD limits surgical options and treatment opportunities because of the limited lung function and cardiopulmonary complications (8).

The latest advances in video-assisted thoracic surgery (VATS) have reduced surgery-related morbidity and mortality in patients with non-small cell lung cancer (NSCLC) (9). Minimally invasive surgical techniques may have a substantial beneficial impact on the ability of patients with COPD to tolerate surgery. The purpose of this study is to analyze the clinical characteristics associated with postoperative complications in COPD patients undergoing VATS for primary lung cancer, and to explore the criteria that influence the choice of surgery between lobectomy and sublobar resection. We present the following article in accordance with the STROBE reporting checklist (available at https://dx.doi.org/10.21037/tlcr-21-449).

Methods

Setting and participants

The study recruited patients with COPD and newly diagnosed lung cancer who were hospitalized in the First Affiliated Hospital of Guangzhou Medical University. Between December 2015 and June 2020, NSCLC patients diagnosed with moderate to extremely severe COPD according to the Global Guidelines for the Diagnosis and Treatment of COPD were enrolled in the study. The criteria for determining COPD severity were based on the following Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification standard of COPD: moderate = FEV1/forced vital capacity (FVC) ≤70% and 50%≤ FEV1 <80% predicted; severe COPD = FEV1/FVC ≤70% and 30%≤ FEV1 <50% predicted; extremely severe COPD = FEV1/FVC ≤70% and FEV1 <30%.

Study design

This observational cross-sectional design was used to allow for complications estimation. The data were prospectively collected using a structured study data sheet. The study was approved by the ethics committee of the First Affiliated Hospital of Guangzhou Medical University (18-041/1616). The requirement for informed consent from each patient was waived due to the retrospective nature of this analysis. According to the anatomical location and staging defined by the International Union for Cancer Control (UICC) guidelines (2007), all tumors were considered operable. All patients received at least 1 week of standardized COPD treatments, including medication and physical therapy to improve lung function. All patients were intubated with double-lumen endotracheal intubation. The patients were managed with antibiotics, bronchial relaxants, antispasmodics, phlegm-reducing techniques, oxygen therapy and physical sputum excretion after surgery. Those with poor sputum expectoration were treated with bronchoscopy, and those with respiratory failure were treated with mechanical ventilation.

Outcome definition

Intraoperative complications include injuries to blood vessels, nerves and other tissues and organs, and intraoperative bleeding that requires blood transfusion. Postoperative complications include: (I) cardiac complications (CCs) (congestive heart failure, myocardial infarction, arrhythmia and pulmonary edema, etc.); (II) respiratory complications (RCs) (pneumonia, atelectasis, pleural effusion or breathing (Machine); (III) venous thromboembolism events [deep vein thrombosis (DVT) or pulmonary embolism]; (IV) bleeding that requires blood transfusion or blood products; (V) infections other than pneumonia (wound infection or abscess); and (VI) re-admission due to surgical complications or reoperation. Data on preoperative lung function tests, operation duration, duration of indwelling chest tube, and length of hospital stay were also collected. All procedures performed in this study involving human participants were in accordance with the Declaration of Helsinki (as revised in 2013).

Statistical analysis

The Kolmogorov-Smirnov test is used to check the distribution of measured data. Continuous variables with normal distribution are expressed as mean ± standard deviation and 95% confidence interval, and independent sample t test is used. Categorical variables are expressed as frequencies and percentages, using the χ2 test. The chi-square test or Fisher’s exact test (as the case may be) was used to test the predictive factors of postoperative complications (demographics, comorbidities, surgery, etc.) on the categorical data and Student t-test or Mann-Whitney U test [as the case may be (history and surgical procedures)] for continuous data. A multiple logistic regression model with stepwise forward elimination was used to evaluate the independent associations between potential predictors and complications. This study used a two-sided test level, P<0.05 considered the difference to be statistically significant. All statistical analyses were performed using SPSS statistical software (version 19.0; IBM SPSS, Armonk, New York, USA), and graphs were analyzed using GraphPad Prism software (version 7.0; GraphPad Software, San Diego, California, USA).

Results

Baseline clinical data characteristics

From December 2015 to June 2020, a total of 1084 patients with ASA scores of III-IV and undergoing surgery were reviewed from the database, of which 175 were diagnosed as primary lung cancer with moderate – extremely severe COPD. Among of them, 37 patients with missing data of pulmonary function tests or no available records of complication event were excluded. Finally, 138 patients were included in the current analysis, including 118 men (86%) and 20 women (14%), the flow diagram of patients’ selection was shown in Figure S1. The baseline characteristics of the patients are summarized in . The mean age was 67 years (63–74 years). Seventy-seven patients were long-term smokers. The preoperative FEV1/FVC was 69.9%, and 60% (83/138) of patients were categorized as moderate stage, 30% (40/138) were categorized as severe, and 11% (15/138) were categorized as extremely severe. The mean preoperative FEV1 was 1.33 L (SD =0.39), and the mean FEV1% was 51.23% (41.43–60.00%). Among them, 97 cases were stage I, 20 cases were stage II, and 21 cases were stage IIIA. None patient had significant contraindications, such as cardiovascular, digestive, urinary, endocrine, or other systemic diseases.

Table 1

Baseline characteristics of the enrolled primary lung cancer patients with COPD

Characteristics	N [%]
Total	138
Age (years)
<68	65 [47]
≥68	73 [53]
Mean (± SD)	67.61±8.406
Smoking status
Nonsmoker	59 [43]
Former smoker	34 [25]
Current smoker	43 [32]
Gender
Male	118 [86]
Female	20 [14]
Past medical history
Hypertension	51 [37]
Diabetes type II	19 [14]
Coronary heart disease	15 [11]
Tuberculosis	7 [5]
Asthma	10 [7]
Chronic renal insufficiency	7 [5]
Arrhythmia	3 [2[
Cerebral infarction	8 [6]
COPD GOLD stages
Moderate	83 [60]
Severe	40 [29]
Extremely severe	15 [11]
Preoperative pulmonary function indexes
FEV1 (L)	1.33±0.39
FEV1%	51.23 (41.43–60.00)
FVC (L)	2.45±0.66
FVC%	72.25 (70.02–75.18)
Tumor location
Upper lobe	81 [59]
Middle lobe	11 [8]
Lower lobe	46 [33]
Surgical procedures
Lobectomy	72 [52]
Sublobar resections	66 [48]
Overall surgical time (min)
Mean (± SD)	147.55±77.12
Overall anesthesia time (min)
Mean (± SD)	231.40±93.24
Intraoperative bleeding (mL)
Mean (25–75%)	111.38 (20–100)
Intraoperative complications
Steady	136 [98.6]
Hemorrhagic shock	1 [0.7]
Atrial fibrillation	1 [0.7]
Histology
Squamous cell	45 [33]
Adenocarcinoma	82 [59]
Other types	11 [8]
TNM stages (8th Edition)
IA	67 [49]
IB	30 [22]
IIA	14 [10]
IIB	6 [4]
IIIA	17 [12]
IIIB	4 [3]
Respiratory rehabilitation interventions
BiPAP-assisted ventilation	43 [31]
Sputum suction via fiberoptic bronchoscope	18 [13]
Lengths of stay (d)
Mean (± SD)	7.99±4.78
Volume of drainage (mL)
Mean (± SD)	914.06

COPD, chronic obstructed pulmonary diseases; GOLD, Global Initiative for Chronic Obstructive Lung Disease; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; TMN, tumor-node-metastasis; BiPAP, bilevel positive airway pressure.

Operative situations

Regarding to the surgical approaches, 52% patients (72/138) received VATS lobectomy with systematic lymph node dissections, and 48% patients (66/138) received VATS sublobar resections (included wedge resections or segmentectomy) with lymph node dissections, both under general mechanical ventilation anesthesia. The majority of procedures were uneventful; only 1 patient suffered hemorrhagic shock caused by unexpected heavy bleeding due to extensive chest adhesion. Another patient had atrial fibrillation intraoperatively and was given amiodarone for cardioversion. No mortality occurred during the surgery ().

Postoperative complications

For the primary outcome, 33% of patients (46/138) presented with postoperative complications. More specifically, 28% of patients (39/138) had respiratory system complications, and 9% of patients (13/138) had cardiac system complications (). Of these, postoperative air leak and atelectasis were reported in 9% of patients (13/138), which was the most common postoperative adverse event in this cohort and was managed by prolonged (>7 days) chest tube drainage and supportive treatments. Furthermore, 8% of patients (11/138) were found to have aggravated pulmonary infection, which was treated with upgraded antibiotics; and 7% of patients (9/138) had pleural effusion postoperatively, which was treated with extra thoracentesis to drain excess fluid from the pleural cavity. For other postoperative complications, 3% of patients (4/138) were diagnosed with type II respiratory failure and 1.5% patients (2/138) with chylothorax. In total, 31% of patients (43/138) had poor conditions of pulmonary ventilation postoperatively and needed to receive bilevel positive airway pressure (BiPAP) mode noninvasive mechanical ventilation, while 13% of patients (18/138) received sputum suction via fiberoptic bronchoscope (). However, seven patients still required further mechanical ventilation under nasal or oral endotracheal intubation, and all these patients were successfully weaned, ultimately without any assisted ventilation.

Figure 1

The postoperative complication rates in primary lung cancer patients with moderate to extremely severe COPD. COPD, chronic obstructed pulmonary diseases.

Next, the univariate analysis of the overall complications (OCs), respiratory or cardiac system complications stratified by clinical characteristics was conducted (). We found that GOLD stages showed statistically significant correlations with OC rate (P=0.044) and RC rate (P=0.03). Moreover, significantly frequent OC rates occurred in extremely severe COPD patients compared to moderate [odds ratio (OR) =4.550, P=0.033) and severe grade (OR =5.910, P=0.015) COPD patients. Similarly, significant higher RC rates were observed in extremely severe COPD patients compared to the moderate (OR =3.857, P=0.050) and severe grade (OR =7.062, P=0.008) subgroups (). However, we did not note significant differences in the incidence of any complication categories in terms of gender, age, smoking history, pathological stages based on the eighth tumor-node-metastasis (TNM) staging system, tumor location, or surgical approach (lobectomy vs sublobar resection) (). Furthermore, in multivariate analysis, the COPD grades were not independent risk factors for the incidence of OCs but were strongly associated with RCs (P=0.024) ().

Table 2

Univariate analysis of overall, respiratory, and cardiac system complications stratified by clinical characteristics

Characteristics	Total	Overall complications (N)	P value	Respiratory complications (N)	P value	Cardiac Complications (N)	P value
Gender
Men	117	39	0.372	33	0.389	12	0.492
Women	19	7		6		1
Age
>68 years	65	21	0.833	18	0.797	9	0.215
≤68 years	73	25		21		4
Smoking history
Nonsmoker	54	16	0.240	12	0.220	8	0.101
Former smoker	39	11		12		2
Current smoker	45	19		15		3
GOLD stages
Moderate	83	26	0.044	23	0.030	10	0.423
Severe	40	10		7		2
Extremely severe	15	10		9		1
TNM stage
I	97	29	0.501	25	0.499	9	0.817
II	20	8		6		2
III	21	9		8		2
Tumor locations
Upper	81	28	0.878	25	0.751	6	0.826
Middle	11	4		5		2
Lower	46	14		9		5
Surgical strategy
Lobectomy	72	23	0.862	18	0.549	7	0.899
Sublobar resections	66	23		23		6

COPD, chronic obstructed pulmonary diseases; GOLD, Global Initiative for Chronic Obstructive Lung Disease; TMN, tumor-node-metastasis.

Figure 2

The multiple comparison of overall and respiratory complication rates between multiple GOLD stages. (A) The overall complication rate. Significantly higher overall complication rates occurred in extremely severe COPD patients compared to moderate (OR =4.550, P=0.033) and severe grade (OR =5.910, P=0.015) COPD patients. (B) The respiratory complication rate. Significant higher respiratory complication rates occurred in extremely severe COPD patients compared to moderate (OR =3.857, P=0.050) and severe grade (OR =7.062, P=0.008) subgroups. COPD, chronic obstructed pulmonary diseases; GOLD, Global Initiative for Chronic Obstructive Lung Disease; OR, odds ratio.

Table 3

Multivariate regression analysis of respiratory complications among primary lung cancer patients with moderate to extremely severe COPD

Characteristics	B*	P value	OR	95% CI
				Lower limit	Upper limit
Constants	1.270	0.000	0.281
GOLD stages
Moderate (reference)		0.027
Severe	0.934	0.034	2.545	1.072	6.038
Extremely severe	1.453	0.030	4.275	1.154	15.843

*B, regression coefficients. COPD, chronic obstructed pulmonary diseases; OR, odds ratio; GOLD, Global Initiative for Chronic Obstructive Lung Disease.

Furthermore, the influence factors of specific common complications were analyzed. The univariate analysis showed that patients with extremely severe COPD had a significantly increased rate of atelectasis compared to patients with moderate (OR =10.340, P=0.017) or severe (OR =7.884, P=0.005) COPD. Also, patients who received VATS lobectomy had a significantly higher atelectasis rate than those who received VATS sublobar resections (P=0.049). Based on the multivariate logistics regression analysis of atelectasis, we found that the grades of COPD (moderate, P=0.029; severe, P=0.028; or extremely severe, P=0.019) and the surgical procedure (lobectomy or sublobar resection, P=0.043) were independent risk factors for atelectasis postoperatively (). None of the other RCs showed a correlation with clinical parameters.

Table 4

Univariate and multivariate analysis for postoperative atelectasis among primary lung cancer patients with moderate to extremely severe COPD

Variables	Univariate analysis		Multivariate analysis
	P value		B	OR (95% CI)	P value
GOLD stages	0.002
Moderate (reference)					0.029
Severe	0.818		1.755	5.786 (1.071–31.264)	0.028
Extremely severe	0.005		2.315	10.125 (1.531–66.662)	0.019
Surgical strategy	0.049
Sublobar resections (reference)
Lobectomy			1.214	0.189 (0.037–0.949)	0.043

COPD, chronic obstructed pulmonary diseases; OR, odds ratio; GOLD, Global Initiative for Chronic Obstructive Lung Disease.

Influence of the severity of COPD on perioperative factors

The impact of perioperative factors, including the surgical and anesthesia time, volume of intraoperative bleeding, length of stay, and duration and volume of drainage, for moderate or severe/extremely severe COPD patients is shown in Table S1. A lower incidence of intraoperative bleeding volume was observed in the moderate COPD group compared with the severe/extremely severe COPD group (P=0.017). There were no differences in the other perioperative factors between the moderate and severe/extremely severe COPD groups.

Discussion

Our study examined the in-hospital postoperative complications in primary lung cancer patients with moderate to extremely severe COPD at our center. The results indicated that COPD grades and surgical treatments had profound impact on the postoperative outcomes. In total, 46 (33%) of the 138 patients experienced postoperative complications. Previous studies have reported a postoperative pulmonary complications frequency of 10–40% in cancer patients undergoing VATS lobectomy (10-13), our study showed the postoperative complication frequency in lung cancer patients with moderate/severe COPD undergoing VATS surgery is relatively higher than common lung cancer patients. In the present study, the most common postoperative complication was atelectasis (13/138, 9%), followed by pulmonary infection (11/138, 8%), pleural effusion (9/138, 7%), respiratory failure (4/138, 3%), and chylothorax (2/138, 1%). Moreover, there was a difference in the RC rates between extremely severe COPD patients and moderate/severe COPD patients (P=0.03), which was mainly attributable to parenchymal air leak or atelectasis, which was the most frequent complication in this cohort.

We sought to identify the independent risk factors that were significantly associated with postoperative complications following VATS. In our study, the rates of postoperative complication were significantly increased with a higher grade of COPD based on the GOLD criteria determined by univariate analysis. Meanwhile, the COPD grades were an independent risk factor for the postoperative RCs (P=0.024) in multivariate analysis, which was consistent with previous studies (10). But our finding that FEV1% or FVC% predicted was not predictive of postoperative complications in VATS which was supported by Berry et al. (14). Moreover, we found that the grades of COPD and surgical procedures were 2 independent risk factors for postoperative atelectasis. This may be due to the poor quality of lung parenchyma and weakened elastic retraction of emphysema, thereby delaying lung tissue recovery (15). Postoperative atelectasis can be treated with airway clearance techniques, including postural drainage and coughing, and bronchial suction using bronchoscopy or a tracheal catheter inserted through cricothyroid ligament as needed (16). With regards to the impact of surgical procedures, lobectomy has higher rates of air leak than does sublobar resection, which may be attributable to the radical anatomical resection. This leads to greater surgical soft tissue trauma and markedly longer healing times compared to the “compromise” of nonradical sublobar resection.

Furthermore, we believed that patients undergoing VATS lung cancer resection who develop postoperative pulmonary complications need more physiotherapy, including sputum clearance and lung expansion. For instance, in our study, 43 patients (31%) received BiPAP mode noninvasive mechanical ventilation under poor conditions of pulmonary ventilation postoperatively, and 18 patients (13%) received sputum suction via fiberoptic bronchoscope. BiPAP may be considered as an alternative treatment for postoperative respiratory failure in patients that undergo primary lung cancer resection and may significantly improve respiratory parameters and oxygenation from baseline values (17,18). Pulmonary rehabilitation has been shown to improve the lung function recovery rate following surgery and may decrease postoperative pulmonary complications (19). Pulmonary infection or pneumonia was the second most common complication in our study, and should also thus not be ignored, as it is the leading causes of postoperative morbidity and death (20), and patients with COPD had higher rates of postoperative pneumonia (21). A Cochrane systematic review of 7 randomized controlled trials emphasized that treatment with a combination of corticosteroids/long-acting beta 2-agonists (LABA) (fluticasone and salmeterol) increases the risk of pneumonia in patients with COPD (22). Treatment of postoperative pulmonary infection starts with microbiological studies of respiratory samples followed by a determination of the presence of sepsis and risk factors for multidrug-resistant pathogens. Subsequently, adequate selection of antibiotics and the escalation or de-escalation principle is required (23).

From a clinical point of view, due to limited lung function, the presence of COPD in primary lung cancer may increase the risk of complications during and after lung surgery. Previous study showed that lung cancer patients with COPD have a worse prognosis than those without COPD (24). The advent of VATS techniques provides a safe alternative for individuals with poor physical performance status (PS) who may have potential high rates of postoperative complications (25,26). This minimally invasive surgery reduces the adverse effects on lung function because it limits damage to the chest wall and causes minimal trauma to the respiratory muscles (27,28). Partial resection through VATS may still have therapeutic benefits. If VATS can be selected, some high-risk patients (elderly and/or poor lung function) who are not suitable for thoracotomy can be considered candidates for surgery (29,30). Yet, thoracic surgeons still must face the problem of the surgical approach under VATS. For normal patients with stage I NSCLC, anatomic lobectomy is better than sublobar resection (segmentectomy or wedge resection) (31). However, many patients with COPD have impaired lung function, which may affect their ability to tolerate surgery. The local recurrence rate of sublobar resection is 3 times higher than that of lobectomy (31) and is an inferior approach for any patient with early-stage disease. Thus, it is necessary to further investigate the optimal candidates with COPD who are suitable for VATS lobectomy.

VATS pulmonary surgery is technically feasible and safe in selected primary lung cancer patients with moderate to extremely severe COPD; in our study, all surgeries were performed through VATS without conversion to thoracotomy, and no patients died during hospitalization. The surgical approach is dependent on an optimal perioperative management, which may include appropriate medical therapy and preoperative and postoperative pulmonary rehabilitation (32), along with series of presurgical evaluations (7,33) such as the use of pulmonary function studies, cardiopulmonary exercise testing, and nuclear perfusion scanning and intraoperative management such as ischemic preconditioning (IPC) (34,35), which enable thoracic surgeons to assess pulmonary risk and select patient for lung resection. When formulating surgical strategies, all cases must be individualized and analyzed from different perspectives for the indications and contraindications of VATS lobectomy for the treatment of lung cancer.

However, our study was limited by its retrospective design, the number of patients is small, and the control group is lacking for comparison. Also, the number of cases of positive postoperative complications was not sufficiently large to reach persuasive statistical power, and there were no standard criteria for identifying and recording the severity of complications. Future studies should use well-validated scales to assess postoperative complications.

Conclusions

In summary, our experience showed that the aggravation of COPD is associated with an increased incidence of postoperative complications, especially atelectasis. For patients with moderate to severe COPD, careful perioperative evaluation should be performed to determine the indicators that influence the surgical choice between lobectomy and sublobar resection.

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