Severe Dengue with Rapid Onset Dementia, Apraxia of Speech and Reversible Splenial Lesion.

Dengue has several neurological manifestations of which reversible splenial lesion of the corpus callosum (RESLES) is a rare one. RESLES is characterized by mild encephalopathy and reversible splenial lesions on magnetic resonance imaging (MRI) that usually resolve in 2 to 4 weeks without any sequelae. 1 2 3

A 32-year-old gentleman without comorbidities presented with fever, headache, vomiting and myalgia for 7 days followed by gait unsteadiness, language impairment with articulation errors and mild confusion. His Glasgow coma scale score was 14/15 and had normal vitals except for oxygen saturation of 93%. He scored 17/30 on Montreal Cognitive Assessment with impairments in clock drawing, trail making, attention, memory, orientation and language domains. He had significant impairment in frontal assessment battery (score 8/18) and Trail A and B tests. He was dysarthric with normal comprehension noted on auditory word recognition and sequential commands. Speech was significantly distorted with incorrect speech sounds, groping for the right sounds, trial and error attempts and omission of certain phrases during repetition and paragraph reading. There was undue stress on certain syllables with loss of prosody. He could, however, show how to blow out a match correctly and do other oral gestures. Naming and writing were also normal. There was mild incoordination of the limbs and gait ataxia. Laboratory results showed neutropenia, thrombocytopenia, raised liver enzymes and high blood sugar. Dengue nonstructural protein 1 antigen, immunoglobulin M, and immunoglobulin G were positive. MRI brain revealed an isolated hyperintense, boomerang-shaped lesion involving splenium of the corpus callosum in diffusion-weighted imaging (DWI), and fluid-attenuated inversion recovery (FLAIR) sequences ( Fig. 1 ). Both clinical and radiological abnormalities resolved completely within a month.

Fig. 1

Magnetic resonance imaging brain diffusion-weighted image shows hyperintensity in the splenium of the corpus callosum.

Severe dengue was diagnosed based on thrombocytopenia, plasma leakage, liver and central nervous system involvement. 4 Unlike the mild cognitive impairment reported in 90% of RESLES cases, our patient presented with a wide range of cognitive impairments that included apraxia of speech, executive dysfunction, impairment in attention and memory along with mild gait ataxia and dysarthria. RESLES has been reported in association with several conditions that cause cytotoxic edema of the splenium. 2 5 6

Although dengue virus by itself may have caused RESLES in our case, it appears more likely to be multifactorial. Additional etiological factors reported to be directly associated with RESLES that may have been involved in this case are hyperglycemia, hypovolemia, vascular hyperpermeability and hepatic dysfunction. 2 5 The widespread cognitive changes without the radiological features seen in dengue encephalitis such as bilateral symmetric changes in basal ganglia, thalamus, pons, temporal lobes or cerebellum support this view. 7

Our case extends the spectrum of neurological abnormalities associated with reversible splenial lesions and severe dengue. Severe cognitive impairment and apraxia of speech may rarely occur in severe dengue without corresponding radiological abnormalities as in this case, and may be multifactorial. Diligent attention to associated systemic abnormalities will ensure good outcome in such situations.