Wenzhen Li1, Wenyu Ruan2, Xiuqing Cui3, Zuxun Lu1, Dongming Wang4. 1. Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. 2. Shangluo Central Hospital, Shangluo, Shaanxi, 726000, China. 3. Institute of Health Surveillance, Analysis and Protection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, 430079, China. 4. Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address: wangdm@hust.edu.cn.
Abstract
OBJECTIVE: We aimed to evaluate the relationship between blood volatile organic aromatic compounds (VOACs) across adulthood and mortality. METHODS: A total of 16,968 participants from the National health and Nutrition Examination Surveys (NHANES 1988-1994 and 1999-2014) were included in the present study. Cox proportional hazards models were used to explore the associations between VOACs and total or cause-specific mortality. RESULTS: A total of 1,282 deaths occurred among 16,968 participants with a median follow-up of 8.06 years. We observed significant positive dose-response relationship between VOACs including benzene, ethylbenzene, o-xylene, m-/p-xylene and BEX (the sum of benzene, ethylbenzene, m-/p-and o-xylene concentrations) and total mortality, the multiple adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were 1.24 (1.13, 1.36), 1.15 (1.04, 1.27), 1.10 (1.00, 1.23), 1.09 (1.01, 1.19) and 1.21 (1.08, 1.35), respectively. In addition, all VOACs significantly elevated risk of the mortality from cancer, and benzene was associated with risk of the mortality from heart disease and the HRs and 95% CIs was 1.39 (1.09-1.77). For non-smokers, benzene, ethylbenzene and BEX were associated with elevated risk of total mortality and the mortality from cancer, and benzene was associated with risk of the mortality from heart disease. CONCLUSIONS: Blood VOACs are associated with increased risks of total and specific-cause mortality, which are also observed among non-smokers.
OBJECTIVE: We aimed to evaluate the relationship between blood volatile organic aromatic compounds (VOACs) across adulthood and mortality. METHODS: A total of 16,968 participants from the National health and Nutrition Examination Surveys (NHANES 1988-1994 and 1999-2014) were included in the present study. Cox proportional hazards models were used to explore the associations between VOACs and total or cause-specific mortality. RESULTS: A total of 1,282 deaths occurred among 16,968 participants with a median follow-up of 8.06 years. We observed significant positive dose-response relationship between VOACs including benzene, ethylbenzene, o-xylene, m-/p-xylene and BEX (the sum of benzene, ethylbenzene, m-/p-and o-xylene concentrations) and total mortality, the multiple adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were 1.24 (1.13, 1.36), 1.15 (1.04, 1.27), 1.10 (1.00, 1.23), 1.09 (1.01, 1.19) and 1.21 (1.08, 1.35), respectively. In addition, all VOACs significantly elevated risk of the mortality from cancer, and benzene was associated with risk of the mortality from heart disease and the HRs and 95% CIs was 1.39 (1.09-1.77). For non-smokers, benzene, ethylbenzene and BEX were associated with elevated risk of total mortality and the mortality from cancer, and benzene was associated with risk of the mortality from heart disease. CONCLUSIONS: Blood VOACs are associated with increased risks of total and specific-cause mortality, which are also observed among non-smokers.
Authors: Pan Pan Wang; Xin Song; Xue Ke Zhao; Meng Xia Wei; She Gan Gao; Fu You Zhou; Xue Na Han; Rui Hua Xu; Ran Wang; Zong Min Fan; Jing Li Ren; Xue Min Li; Xian Zeng Wang; Miao Miao Yang; Jing Feng Hu; Kan Zhong; Ling Ling Lei; Liu Yu Li; Yao Chen; Ya Jie Chen; Jia Jia Ji; Yuan Ze Yang; Jia Li; Li Dong Wang Journal: Front Oncol Date: 2022-01-28 Impact factor: 6.244