Literature DB >> 3429345

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

I Takahashi1, E Kobayashi, K Asano, M Yoshida, H Nakano.   

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Year:  1987        PMID： 3429345     DOI： 10.7164/antibiotics.40.1782

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


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  29 in total

1.  UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines.

Authors:  A Monks; E D Harris; A Vaigro-Wolff; C D Hose; J W Connelly; E A Sausville
Journal:  Invest New Drugs       Date:  2000-05       Impact factor: 3.850

2.  Stimulatory effect of reconstituted basement membrane components (matrigel) on the colony formation of a panel of human lung cancer cell lines in soft agar.

Authors:  S Yoshida; E Shimizu; T Ogura; M Takada; S Sone
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

Review 3.  Total (bio)synthesis: strategies of nature and of chemists.

Authors:  Alexandra A Roberts; Katherine S Ryan; Bradley S Moore; Tobias A M Gulder
Journal:  Top Curr Chem       Date:  2010

4.  Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.

Authors:  Sheena M Aris; Yves Pommier
Journal:  Cancer Res       Date:  2011-12-21       Impact factor: 12.701

Review 5.  New drug development in non-Hodgkin lymphomas.

Authors:  B D Cheson
Journal:  Curr Oncol Rep       Date:  2001-05       Impact factor: 5.075

Review 6.  Protein kinase C targeting in antineoplastic treatment strategies.

Authors:  W D Jarvis; S Grant
Journal:  Invest New Drugs       Date:  1999       Impact factor: 3.850

7.  Physiological modeling of altered pharmacokinetics of a novel anticancer drug, UCN-01 (7-hydroxystaurosporine), caused by slow dissociation of UCN-01 from human alpha1-acid glycoprotein.

Authors:  E Fuse; A Hashimoto; N Sato; H Tanii; T Kuwabara; S Kobayashi; Y Sugiyama
Journal:  Pharm Res       Date:  2000-05       Impact factor: 4.200

Review 8.  Signal transduction pathways: new targets in oncology.

Authors:  R K Sweeb; J H Beijnen
Journal:  Pharm World Sci       Date:  1993-12-17

9.  Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

Authors:  David Komander; Gursant S Kular; Jennifer Bain; Matthew Elliott; Dario R Alessi; Daan M F Van Aalten
Journal:  Biochem J       Date:  2003-10-15       Impact factor: 3.857

Review 10.  Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1).

Authors:  Dale G Nagle; Yu-Dong Zhou
Journal:  Curr Drug Targets       Date:  2006-03       Impact factor: 3.465
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