| Literature DB >> 3429336 |
K E Wilson1, J E Flor, R E Schwartz, H Joshua, J L Smith, B A Pelak, J M Liesch, O D Hensens.
Abstract
The isolation of difficidin (1) and oxydifficidin (2) from fermentation broth of Bacillus subtilis ATCC 39320 and the physico-chemical characterization of these labile antibiotics are described. The structures of the compounds represent a new class of antibiotics, characterized as highly unsaturated 22-membered macrolide phosphates. Difficidin and oxydifficidin undergo reversible thermal isomerization to 3 and 4 respectively. Biological evaluation of the isomers is presented.Entities:
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Year: 1987 PMID： 3429336 DOI： 10.7164/antibiotics.40.1682
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649