Miguel A Vences1, Juan J Pareja-Ramos2, Paula Otero3, Liz E Veramendi-Espinoza4, Melissa Vega-Villafana5, Julissa Mogollón-Lavi6, Eduardo Morales-Romero7, Josseline Olivera-Vera8, Carol Meza9, Lucía J Salas-Lazo10, Andy Triveño11, Renzo Marín-Dávalos12, Ricardo Carpio Rodriguez8, Jessica H Zafra-Tanaka13. 1. Departamento de Neurología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. Adress: Avenida Rebagliati 490 Jesús María, Lima, Perú. Email: vens1793@hotmail.com. ORCID: 0000-0002-8538-6242. 2. Departamento de Medicina Interna, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0001-7082-0117. 3. Departamento de Medicina Interna, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0001-7433-7042. 4. Departamento de Especialidades Clínicas, Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima, Perú. ORCID: 0000-0002-6998-9529. 5. Departamento de Medicina Interna, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0003-4116-6317. 6. Departamento de Medicina Interna, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0002-6984-2340. 7. Departamento de Cirugía General y Aparato Digestivo, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0002-6945-6490. 8. Departamento de Medicina Interna, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0003-0934-2085. 9. Servicio de Cirugía de Cabeza, Cuello y Maxilofacial, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0002-3083-225X. 10. Servicio de Cirugía de Cabeza, Cuello y Maxilofacial, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0002-8654-6359. 11. Servicio de Cirugía de Otorrinolaringología, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0002-4014-6528. 12. Departamento de Emergencia, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. ORCID: 0000-0001-9085-3047. 13. Escuela de Medicina, Universidad Científica del Sur, Lima, Perú. ORCID: 0000-0001-6386-6643.
Abstract
OBJECTIVES: To describe and assess clinical characteristics and factors associated with mortality in adult patients with COVID-19 admitted to a national referral hospital in Peru. METHODS: We conducted a prospective cohort study that included hospitalized patients older than 18 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis. Patients with a positive rapid serological test on admission but no respiratory symptoms nor compatible images were excluded. We collected the data from clinical records. RESULTS: A total of 813 adults were included, 544 (66.9%) with confirmed COVID-19. The mean age was 61.2 years (standard deviation: 15.0), and 575 (70.5%) were male. The most frequent comorbidities were hypertension (34.1%) and obesity (25.9%). On admission, the most frequent symptoms were dyspnea (82.2%) and cough (53.9%). A total of 114 (14.0%) patients received mechanical ventilation, 38 (4.7%) were admitted to the intensive care unit, and 377 (46.4%) died. The requirement for ventilatory support, greater lung involvement, and inflammatory markers were associated with higher mortality. It was found that for every 10-year age increase, the risk of dying increased 32% (relative risk: 1.32; 95% confidence interval: 1.25 to 1.38). Those who were admitted to the intensive care unit and and were placed on mechanical ventilation had 1.39 (95% confidence interval: 1.13 to 1.69) and 1.97 (95% confidence interval: 1.69 to 2.29) times the risk of dying compared to those who did not, respectively. CONCLUSION: We found a high mortality rate among hospitalized patients associated with older age, higher inflammatory markers, and greater lung involvement.
OBJECTIVES: To describe and assess clinical characteristics and factors associated with mortality in adult patients with COVID-19 admitted to a national referral hospital in Peru. METHODS: We conducted a prospective cohort study that included hospitalized patients older than 18 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis. Patients with a positive rapid serological test on admission but no respiratory symptoms nor compatible images were excluded. We collected the data from clinical records. RESULTS: A total of 813 adults were included, 544 (66.9%) with confirmed COVID-19. The mean age was 61.2 years (standard deviation: 15.0), and 575 (70.5%) were male. The most frequent comorbidities were hypertension (34.1%) and obesity (25.9%). On admission, the most frequent symptoms were dyspnea (82.2%) and cough (53.9%). A total of 114 (14.0%) patients received mechanical ventilation, 38 (4.7%) were admitted to the intensive care unit, and 377 (46.4%) died. The requirement for ventilatory support, greater lung involvement, and inflammatory markers were associated with higher mortality. It was found that for every 10-year age increase, the risk of dying increased 32% (relative risk: 1.32; 95% confidence interval: 1.25 to 1.38). Those who were admitted to the intensive care unit and and were placed on mechanical ventilation had 1.39 (95% confidence interval: 1.13 to 1.69) and 1.97 (95% confidence interval: 1.69 to 2.29) times the risk of dying compared to those who did not, respectively. CONCLUSION: We found a high mortality rate among hospitalized patients associated with older age, higher inflammatory markers, and greater lung involvement.
Authors: Alonso Soto; Dante M Quiñones-Laveriano; Johan Azañero; Rafael Chumpitaz; José Claros; Lucia Salazar; Oscar Rosales; Liz Nuñez; David Roca; Andres Alcantara Journal: PLoS One Date: 2022-03-02 Impact factor: 3.240