| Literature DB >> 34291647 |
Ramon Andrade de Mello1,2,3, Giovanna Araujo Amaral2, Nathália Moisés Neves2, Estela Gudin Lippo4, Fernanda Parini3, Song Xu5, Maria Tolia6, Nikolaos Charalampakis7, Hakaru Tadokoro2, Pedro Castelo-Branco1, Jinhui Zhu8.
Abstract
Gastric cancer is the fourth most common type of cancer worldwide and the second most lethal. Gastric cancer biomarkers can be used for diagnosis, prediction of sensitivity to treatment, and prognosis. The following search terms were applied to PubMed as of December 2020: 'gastric cancer classification', 'gastric cancer epidemiology', 'cancer metastasis' and 'gastric cancer biomarker'. Only experimental studies were reported in the 'biomarkers' section. Some biomarkers can serve as therapeutic targets for antitumoral drugs. The genes analyzed include E-cadherin, RPRM, XAF1, MINT25, TFF1, p16 and p53. The miRNAs analyzed include miR-18a, miR185-5p, miR-125b and miR-21. Some molecules were associated with metastasis of gastric cancer, specifically those involved with EMT process and tissue degradation.Entities:
Keywords: biomarkers; diagnosis; gastric cancer; literature review; prognosis; sensitivity; treatment
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Year: 2021 PMID： 34291647 DOI： 10.2217/fon-2021-0084
Source DB: PubMed Journal: Future Oncol ISSN： 1479-6694 Impact factor: 3.404