Literature DB >> 34291386

Successful multimodality treatment for advanced hepatocellular carcinoma with tumor thrombosis of the main portal trunk: a case study.

Yumi Kosaka1, Tomokazu Kawaoka1, Yutaro Ogawa1, Kei Amioka1, Kensuke Naruto1, Yuki Yoshikawa1, Yuwa Ando1, Yosuke Suehiro1, Kenji Yamaoka1, Yasutoshi Fujii1, Shinsuke Uchikawa1, Atsushi Ono1, Masami Yamauchi1, Michio Imamura1, Keigo Chosa2, Kazuo Awai2, Yasushi Nagata3, Kazuaki Chayama4,5,6, Hiroshi Aikata7.   

Abstract

The overall survival of patients with advanced hepatocellular carcinoma with tumor thrombosis of the main trunk or bilobar branches of the portal vein is extremely poor. Moreover, there is no standard treatment established for the condition. Herein, we present the case of a 65-year-old man who were treated the patient with hepatic arterial infusion chemotherapy, radiation therapy for tumor thrombosis, portal vein stent placement, lenvatinib administration, and renal venous shunt embolization. A complete response was observed according to mRECIST and the patient has been alive for 14 months since treatment initiation with no tumor recurrence.
© 2021. Japanese Society of Gastroenterology.

Entities:  

Keywords:  Hepatic arterial infusion chemotherapy; Hepatocellular carcinoma; Lenvatinib; Portal vein tumor thrombosis; Radiation therapy

Year:  2021        PMID: 34291386     DOI: 10.1007/s12328-021-01481-9

Source DB:  PubMed          Journal:  Clin J Gastroenterol        ISSN: 1865-7265


  36 in total

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Journal:  Lancet       Date:  2018-01-05       Impact factor: 79.321

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Journal:  Cancer       Date:  1997-05-15       Impact factor: 6.860

3.  Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion.

Authors:  Shuntaro Obi; Haruhiko Yoshida; Risa Toune; Tadao Unuma; Miho Kanda; Shinpei Sato; Ryosuke Tateishi; Takuma Teratani; Shuichiro Shiina; Masao Omata
Journal:  Cancer       Date:  2006-05-01       Impact factor: 6.860

4.  Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma.

Authors:  Dae Yong Kim; Won Park; Do Hoon Lim; Joon Hyoek Lee; Byung Chul Yoo; Seung Woon Paik; Kwang Cheol Kho; Tae Hyun Kim; Yong Chan Ahn; Seung Jae Huh
Journal:  Cancer       Date:  2005-06-01       Impact factor: 6.860

5.  Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer.

Authors:  S Rossi; M Di Stasi; E Buscarini; P Quaretti; F Garbagnati; L Squassante; C T Paties; D E Silverman; L Buscarini
Journal:  AJR Am J Roentgenol       Date:  1996-09       Impact factor: 3.959

6.  [The efficacy of hepatic arterial infusion therapy for advanced hepatocellular carcinoma according to extrahepatic collateral feeding vessels].

Authors:  Byoung Kuk Jang; Woo Jin Chung; Kyung Sik Park; Kwang Bum Cho; Jae Seok Hwang; Sung Hoon Ahn; Young Hwan Kim; Jin Soo Choi; Jung Hyeok Kwon
Journal:  Korean J Hepatol       Date:  2005-12

7.  Prognosis of hepatocellular carcinoma: the BCLC staging classification.

Authors:  J M Llovet; C Brú; J Bruix
Journal:  Semin Liver Dis       Date:  1999       Impact factor: 6.115

8.  Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial.

Authors:  Ann-Lii Cheng; Yoon-Koo Kang; Zhendong Chen; Chao-Jung Tsao; Shukui Qin; Jun Suk Kim; Rongcheng Luo; Jifeng Feng; Shenglong Ye; Tsai-Sheng Yang; Jianming Xu; Yan Sun; Houjie Liang; Jiwei Liu; Jiejun Wang; Won Young Tak; Hongming Pan; Karin Burock; Jessie Zou; Dimitris Voliotis; Zhongzhen Guan
Journal:  Lancet Oncol       Date:  2008-12-16       Impact factor: 41.316

9.  Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma.

Authors:  Kiminori Uka; Hiroshi Aikata; Shintaro Takaki; Daiki Miki; Tomokazu Kawaoka; Soo Cheol Jeong; Shoichi Takahashi; Naoyuki Toyota; Katsuhide Ito; Kazuaki Chayama
Journal:  J Gastroenterol       Date:  2007-10-15       Impact factor: 7.527

10.  Sorafenib in advanced hepatocellular carcinoma.

Authors:  Josep M Llovet; Sergio Ricci; Vincenzo Mazzaferro; Philip Hilgard; Edward Gane; Jean-Frédéric Blanc; Andre Cosme de Oliveira; Armando Santoro; Jean-Luc Raoul; Alejandro Forner; Myron Schwartz; Camillo Porta; Stefan Zeuzem; Luigi Bolondi; Tim F Greten; Peter R Galle; Jean-François Seitz; Ivan Borbath; Dieter Häussinger; Tom Giannaris; Minghua Shan; Marius Moscovici; Dimitris Voliotis; Jordi Bruix
Journal:  N Engl J Med       Date:  2008-07-24       Impact factor: 91.245

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