Literature DB >> 34291318

Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics.

Umberto Banderali1, Luigi Leanza2, Najmeh Eskandari3, Saverio Gentile4.   

Abstract

Cancer is a collection of diseases caused by specific changes at the genomic level that support cell proliferation indefinitely. Traditionally, ion channels are known to control a variety of cellular processes including electrical signal generation and transmission, secretion, and contraction by controlling ionic gradients. However, recent studies had brought to light important facts on ion channels in cancer biology.In this review we discuss the mechanism linking potassium or chloride ion channel activity to biochemical pathways controlling proliferation in cancer cells and the potential advantages of targeting ion channels as an anticancer therapeutic option.
© 2021. Springer Nature Switzerland AG.

Entities:  

Keywords:  Cancer biology; Chloride channel; Potassium channel; Proliferative signaling; Therapeutic approach

Mesh：

Substances：

Year:  2022        PMID： 34291318     DOI： 10.1007/112_2021_62

Source DB:  PubMed          Journal:  Rev Physiol Biochem Pharmacol        ISSN： 0303-4240            Impact factor:   5.545


  112 in total

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5.  Ion channels in pediatric CNS Atypical Teratoid/Rhabdoid Tumor (AT/RT) cells: potential targets for novel therapeutic agents.

Authors:  Umberto Banderali; Aarthi Jayanthan; Kimberley A Hoeksema; Aru Narendran; Wayne R Giles
Journal:  J Neurooncol       Date:  2011-10-05       Impact factor: 4.130

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Journal:  Mitochondrion       Date:  2009-12-21       Impact factor: 4.160

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Journal:  Br J Cancer       Date:  2011-06-28       Impact factor: 7.640

9.  The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia.

Authors:  Jasmin R Agarwal; Frank Griesinger; Walter Stühmer; Luis A Pardo
Journal:  Mol Cancer       Date:  2010-01-27       Impact factor: 27.401

10.  Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.

Authors:  Naveid A Ali; Jianmin Wu; Falko Hochgräfe; Howard Chan; Radhika Nair; Sunny Ye; Luxi Zhang; Ruth J Lyons; Mark Pinese; Hong Ching Lee; Nicola Armstrong; Christopher J Ormandy; Susan J Clark; Alexander Swarbrick; Roger J Daly
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