Literature DB >> 34290413

How the amino acid leucine activates the key cell-growth regulator mTOR.

Tibor Vellai.   

Abstract

Entities:  

Keywords:  Cancer; Cell biology; Metabolism

Year:  2021        PMID： 34290413     DOI： 10.1038/d41586-021-01943-7

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


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  11 in total

1.  Genetics: influence of TOR kinase on lifespan in C. elegans.

Authors:  Tibor Vellai; Krisztina Takacs-Vellai; Yue Zhang; Attila L Kovacs; László Orosz; Fritz Müller
Journal:  Nature       Date:  2003-12-11       Impact factor: 49.962

2.  The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.

Authors:  Lynne Chantranupong; Sonia M Scaria; Robert A Saxton; Melanie P Gygi; Kuang Shen; Gregory A Wyant; Tim Wang; J Wade Harper; Steven P Gygi; David M Sabatini
Journal:  Cell       Date:  2016-03-10       Impact factor: 41.582

Review 3.  mTOR Signaling in Growth, Metabolism, and Disease.

Authors:  Robert A Saxton; David M Sabatini
Journal:  Cell       Date:  2017-03-09       Impact factor: 41.582

4.  A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

Authors:  Liron Bar-Peled; Lynne Chantranupong; Andrew D Cherniack; Walter W Chen; Kathleen A Ottina; Brian C Grabiner; Eric D Spear; Scott L Carter; Matthew Meyerson; David M Sabatini
Journal:  Science       Date:  2013-05-31       Impact factor: 47.728

5.  Sestrin2 is a leucine sensor for the mTORC1 pathway.

Authors:  Rachel L Wolfson; Lynne Chantranupong; Robert A Saxton; Kuang Shen; Sonia M Scaria; Jason R Cantor; David M Sabatini
Journal:  Science       Date:  2015-10-08       Impact factor: 47.728

6.  Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Authors:  Robert A Saxton; Kevin E Knockenhauer; Rachel L Wolfson; Lynne Chantranupong; Michael E Pacold; Tim Wang; Thomas U Schwartz; David M Sabatini
Journal:  Science       Date:  2015-11-19       Impact factor: 47.728

Review 7.  mTOR at the nexus of nutrition, growth, ageing and disease.

Authors:  Grace Y Liu; David M Sabatini
Journal:  Nat Rev Mol Cell Biol       Date:  2020-01-14       Impact factor: 94.444

8.  Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.

Authors:  Robert A Saxton; Lynne Chantranupong; Kevin E Knockenhauer; Thomas U Schwartz; David M Sabatini
Journal:  Nature       Date:  2016-08-03       Impact factor: 49.962

9.  Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.

Authors:  Qiuyan Chen; Manolo Plasencia; Zhuang Li; Somnath Mukherjee; Dhabaleswar Patra; Chun-Liang Chen; Thomas Klose; Xin-Qiu Yao; Anthony A Kossiakoff; Leifu Chang; Philip C Andrews; John J G Tesmer
Journal:  Nature       Date:  2021-07-14       Impact factor: 49.962

10.  Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Authors:  Oliver D K Maddocks; Celia R Berkers; Susan M Mason; Liang Zheng; Karen Blyth; Eyal Gottlieb; Karen H Vousden
Journal:  Nature       Date:  2012-12-16       Impact factor: 49.962
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  5 in total

Review 1.  The evolutionary and functional divergence of the Atg8 autophagy protein superfamily.

Authors:  Virginia B Varga; Fanni Keresztes; Tímea Sigmond; Tibor Vellai; Tibor Kovács
Journal:  Biol Futur       Date:  2022-06-22

Review 2.  Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance.

Authors:  Jan Gojda; Monika Cahova
Journal:  Biomolecules       Date:  2021-09-28

3.  Inhibition of Glutamine Uptake Resensitizes Paclitaxel Resistance in SKOV3-TR Ovarian Cancer Cell via mTORC1/S6K Signaling Pathway.

Authors:  Gyeongmi Kim; Se-Kyeong Jang; Yu Jin Kim; Hyeon-Ok Jin; Seunghee Bae; Jungil Hong; In-Chul Park; Jae Ho Lee
Journal:  Int J Mol Sci       Date:  2022-08-06       Impact factor: 6.208

4.  Case Report: Extensive Tumor Profiling in Primary Neuroendocrine Breast Cancer Cases as a Role Model for Personalized Treatment in Rare and Aggressive Cancer Types.

Authors:  Dörthe Schaffrin-Nabe; Stefan Schuster; Andrea Tannapfel; Rudolf Voigtmann
Journal:  Front Med (Lausanne)       Date:  2022-06-03

Review 5.  Amino Acid Signaling for TOR in Eukaryotes: Sensors, Transducers, and a Sustainable Agricultural fuTORe.

Authors:  Nanticha Lutt; Jacob O Brunkard
Journal:  Biomolecules       Date:  2022-03-02
  5 in total

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