Olivia Janssen1, Veniamin Ratner2, Jing Lin2, Nathan Fox3, Robert Green2. 1. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. olivia.janssen12@gmail.com. 2. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abstract
OBJECTIVE: To quantify changes in respiratory and glycemic control outcomes following antenatal corticosteroids (ANCS) exposure in late preterm neonates. DESIGN/ METHODS: The study included 500 neonates born between 34 0/7 and 36 6/7 weeks of gestation. Study population was divided into two groups: an immature group (34 0/7-35 6/7 weeks) and a mature group (36 0/7-36 6/7 weeks). Respiratory and glycemic control outcomes were analyzed for each group independently. RESULTS: In the immature group, the odds of developing respiratory distress decreased in neonates exposed to ANCS within 7 days of delivery (aOR 0.42; p = 0.02). In the mature group, ANCS exposure did not change respiratory outcomes, but decreased lowest blood glucose levels (-1.5 ± 0.66 mg/dL per dose, p = 0.02). CONCLUSION: In our study cohort, ANCS administration was associated with improved neonatal respiratory outcomes only for infants in the immature 34 0/7-35 6/7 weeks of gestational age group. ANCS was associated with altered glycemic control only in infants in the mature 36 0/7-36 6/7 weeks of gestational age group.
OBJECTIVE: To quantify changes in respiratory and glycemic control outcomes following antenatal corticosteroids (ANCS) exposure in late preterm neonates. DESIGN/ METHODS: The study included 500 neonates born between 34 0/7 and 36 6/7 weeks of gestation. Study population was divided into two groups: an immature group (34 0/7-35 6/7 weeks) and a mature group (36 0/7-36 6/7 weeks). Respiratory and glycemic control outcomes were analyzed for each group independently. RESULTS: In the immature group, the odds of developing respiratory distress decreased in neonates exposed to ANCS within 7 days of delivery (aOR 0.42; p = 0.02). In the mature group, ANCS exposure did not change respiratory outcomes, but decreased lowest blood glucose levels (-1.5 ± 0.66 mg/dL per dose, p = 0.02). CONCLUSION: In our study cohort, ANCS administration was associated with improved neonatal respiratory outcomes only for infants in the immature 34 0/7-35 6/7 weeks of gestational age group. ANCS was associated with altered glycemic control only in infants in the mature 36 0/7-36 6/7 weeks of gestational age group.
Authors: Maria A Abrantes; Arwin M Valencia; Fayez Bany-Mohammed; Jacob V Aranda; Kay D Beharry Journal: Am J Transl Res Date: 2019-03-15 Impact factor: 4.060
Authors: Joyce A Martin; Brady E Hamilton; Paul D Sutton; Stephanie J Ventura; Fay Menacker; Sharon Kirmeyer; Martha L Munson Journal: Natl Vital Stat Rep Date: 2007-12-05