Kui Xiao1,2,3, Shenggang Liu4, Yijia Xiao4, Yang Wang5, Zhiruo Zhu1,2,3, Yaohui Wang1,2,3, Jiehan Jiang4. 1. Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. 2. Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China. 3. The Respiratory Disease Diagnosis and Treatment Center of Hunan Province, Changsha, Hunan, China. 4. Department of Pulmonary and Critical Care Medicine, University of South China Affiliated Changsha Central Hospital, Changsha City, Hunan Province, China. 5. Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Abstract
BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers. The drug resistance of NSCLC has clinically increased. This study aimed to screen miRNAs associated with NSCLC using bioinformatics analysis. We hope that the screened miRNA can provide a research direction for the subsequent treatment of NSCLC. METHODS: We screened out the common miRNAs after compared the NSCLC-related genes in the TCGA database and GEO database. Selected miRNA was performed ROC analysis, survival analysis, and enrichment analysis (GO term and KEGG pathway). RESULTS: A total of 21 miRNAs were screened in the two databases. And they were all highly expressed in normal and low in cancerous tissues. Hsa-mir-30a was selected by ROC analysis and survival analysis. Enrichment analysis showed that the function of hsa-mir-30a is mainly related to cell cycle regulation and drug metabolism. CONCLUSION: Our study found that hsa-mir-30a was differentially expressed in NSCLC, and it mainly affected NSCLC by regulating the cell cycle and drug metabolism.
BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers. The drug resistance of NSCLC has clinically increased. This study aimed to screen miRNAs associated with NSCLC using bioinformatics analysis. We hope that the screened miRNA can provide a research direction for the subsequent treatment of NSCLC. METHODS: We screened out the common miRNAs after compared the NSCLC-related genes in the TCGA database and GEO database. Selected miRNA was performed ROC analysis, survival analysis, and enrichment analysis (GO term and KEGG pathway). RESULTS: A total of 21 miRNAs were screened in the two databases. And they were all highly expressed in normal and low in cancerous tissues. Hsa-mir-30a was selected by ROC analysis and survival analysis. Enrichment analysis showed that the function of hsa-mir-30a is mainly related to cell cycle regulation and drug metabolism. CONCLUSION: Our study found that hsa-mir-30a was differentially expressed in NSCLC, and it mainly affected NSCLC by regulating the cell cycle and drug metabolism.
Authors: Fred R Hirsch; Giorgio V Scagliotti; James L Mulshine; Regina Kwon; Walter J Curran; Yi-Long Wu; Luis Paz-Ares Journal: Lancet Date: 2016-08-27 Impact factor: 79.321
Authors: Xiaowen Zhang; Huai-Chin Chiang; Yao Wang; Chi Zhang; Sabrina Smith; Xiayan Zhao; Sreejith J Nair; Joel Michalek; Ismail Jatoi; Meeghan Lautner; Boyce Oliver; Howard Wang; Anna Petit; Teresa Soler; Joan Brunet; Francesca Mateo; Miguel Angel Pujana; Elizabeth Poggi; Krysta Chaldekas; Claudine Isaacs; Beth N Peshkin; Oscar Ochoa; Frederic Chedin; Constantine Theoharis; Lu-Zhe Sun; Tyler J Curiel; Richard Elledge; Victor X Jin; Yanfen Hu; Rong Li Journal: Nat Commun Date: 2017-06-26 Impact factor: 14.919