Literature DB >> 3428670

Increased phospholipase A2 and decreased lysophospholipase activity in the small intestinal mucosa after ischaemia and revascularisation.

T Otamiri1, L Franzén, D Lindmark, C Tagesson.   

Abstract

The influence of ischaemia and revascularisation on lipid peroxidation and phospholipid metabolism in the rat small intestinal mucosa was investigated. Two hours of total ischaemia followed by five minutes of revascularisation caused not only accumulation of malondialdehyde in the mucosa, but also increased activity of phospholipase A2, decreased activity of lysophospholipase, and increased ratio between lysophosphatidylcholine and phosphatidylcholine. Pretreatment with the phospholipase A2 inhibitor, quinacrine, prevented the increases in mucosal phospholipase A2 activity and lysophosphatidylcholine/phosphatidylcholine ratio after ischaemia and morphological examinations revealed that the mucosa was then also protected against ischaemic injury. These findings point to the possibility that activation of phospholipase A2 and accumulation of lysophosphoglycerides could be involved in mediating the mucosal injury caused by small intestinal ischaemia.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3428670      PMCID： PMC1433681          DOI： 10.1136/gut.28.11.1445

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  33 in total

1.  Passage of molecules through the wall of the gastrointestinal tract. Increased passive permeability in rat ileum after exposure to lysolecithin.

Authors:  T Bolin; R Sjödahl; T Sundqvist; C Tagesson
Journal:  Scand J Gastroenterol       Date:  1981       Impact factor: 2.423

Review 2.  Intracellular phospholipases A.

Authors:  H van den Bosch
Journal:  Biochim Biophys Acta       Date:  1980-09-30

3.  Calcium regulation of phospholipase A2 is independent of calmodulin.

Authors:  M T Withnall; T J Brown; B K Diocee
Journal:  Biochem Biophys Res Commun       Date:  1984-06-15       Impact factor: 3.575

4.  Improved procedure for the separation of phospholipids by high-performance liquid chromatography.

Authors:  S S Chen; A Y Kou
Journal:  J Chromatogr       Date:  1982-01-08

5.  Time course of changes in porcine myocardial phospholipid levels during ischemia. A reassessment of the lysolipid hypothesis.

Authors:  N A Shaikh; E Downar
Journal:  Circ Res       Date:  1981-08       Impact factor: 17.367

6.  Marked increase of human platelet phospholipase A2 activity in vitro and demonstration of an endogenous inhibitor.

Authors:  L R Ballou; W Y Cheung
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

7.  The influence of phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid peroxides.

Authors:  A Sevanian; S F Muakkassah-Kelly; S Montestruque
Journal:  Arch Biochem Biophys       Date:  1983-06       Impact factor: 4.013

8.  Posthypotensive generation of superoxide free radicals--possible role in the pathogenesis of the intestinal mucosal damage.

Authors:  M H Schoenberg; E Muhl; D Sellin; M Younes; F W Schildberg; U Haglund
Journal:  Acta Chir Scand       Date:  1984

9.  Ischemic injury in the cat small intestine: role of superoxide radicals.

Authors:  D A Parks; G B Bulkley; D N Granger; S R Hamilton; J M McCord
Journal:  Gastroenterology       Date:  1982-01       Impact factor: 22.682

10.  Effects of lysophosphoglycerides on cardiac arrhythmias.

Authors:  R Y Man; T Wong; P C Choy
Journal:  Life Sci       Date:  1983-03-21       Impact factor: 5.037
View more
  12 in total

1.  Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

Authors:  T Gobbetti; S Ducheix; P le Faouder; T Perez; F Riols; J Boue; J Bertrand-Michel; M Dubourdeau; H Guillou; M Perretti; N Vergnolle; N Cenac
Journal:  Br J Pharmacol       Date:  2014-12-15       Impact factor: 8.739

Review 2.  Phospholipase A2-mediated hydrolysis of cardiac phospholipids: the use of molecular and transgenic techniques.

Authors:  L J De Windt; R S Reneman; G J Van der Vusse; M Van Bilsen
Journal:  Mol Cell Biochem       Date:  1998-03       Impact factor: 3.396

3.  Subcellular characteristics of phospholipase A2 activity in the rat kidney. Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion.

Authors:  H Nakamura; R A Nemenoff; J H Gronich; J V Bonventre
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

Review 4.  Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury.

Authors:  Emily Archer Slone; Sherry D Fleming
Journal:  Clin Immunol       Date:  2014-05-09       Impact factor: 3.969

5.  Interleukin-6 changes tight junction permeability and intracellular phospholipid content in a human enterocyte cell culture model.

Authors:  Y Tazuke; R A Drongowski; D H Teitelbaum; A G Coran
Journal:  Pediatr Surg Int       Date:  2003-05-06       Impact factor: 1.827

6.  Intestinal lipid alterations occur prior to antibody-induced prostaglandin E2 production in a mouse model of ischemia/reperfusion.

Authors:  Byron L Sparkes; Emily E Archer Slone; Mary Roth; Ruth Welti; Sherry D Fleming
Journal:  Biochim Biophys Acta       Date:  2010-01-18

7.  Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock.

Authors:  John R Stringham; Ernest E Moore; Fabia Gamboni; Jeffrey N Harr; Miguel Fragoso; Theresa L Chin; Caitlin E Carr; Christopher C Silliman; Anirban Banerjee
Journal:  J Trauma Acute Care Surg       Date:  2014-05       Impact factor: 3.313

8.  Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist.

Authors:  Thiruma V Arumugam; Naomi Arnold; Lavinia M Proctor; Michelle Newman; Robert C Reid; Karl A Hansford; David P Fairlie; Ian A Shiels; Stephen M Taylor
Journal:  Br J Pharmacol       Date:  2003-07-29       Impact factor: 8.739

9.  Quinacrine prevention of intestinal ischaemic mucosal damage is partly mediated through inhibition of intraluminal phospholipase A2.

Authors:  T Otamiri
Journal:  Agents Actions       Date:  1988-12

10.  Phospholipase A2 inhibition prevents mucosal damage associated with small intestinal ischaemia in rats.

Authors:  T Otamiri; M Lindahl; C Tagesson
Journal:  Gut       Date:  1988-04       Impact factor: 23.059
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.