Literature DB >> 34284410

Flexible Cystoscopy in the Setting of Macroscopic Hematuria: Do the Findings Justify Its Use?

Reuben Ben-David1,2, Samuel Morgan2, Ziv Savin1,2, Snir Dekalo1,2, Mario Sofer1,2, Avi Beri1,2, Ofer Yossepowitch1,2, Roy Mano1,2.   

Abstract

BACKGROUND: Patients hospitalized due to gross hematuria frequently complete evaluation in the outpatient setting. The use of office flexible cystoscopy during hospitalization may lead to prompt diagnosis and treatment but can be limited due to low visualization and artifacts that can hamper diagnostic ability.
OBJECTIVE: The objective of this study was to assess flexible cystoscopy findings and yield performed in patients hospitalized due to gross hematuria.
METHODS: Medical records of patients who underwent flexible cystoscopy while hospitalized during September 2018-December 2019 were reviewed. Cystoscopic findings were categorized into (1) suspicious mass in the bladder or prostate, (2) nonsuspicious changes in the bladder, and (3) nondiagnostic exam. Descriptive statistics were used to report the clinical characteristics of the study cohort and the findings of cystoscopy. Univariate logistic regression analyses were used to identify predictors of malignant findings.
RESULTS: The study cohort consisted of 69 patients (median age of 76 years). Initial cystoscopy findings were suspicious for malignancy in 26/69 patients (38%), nonsuspicious for malignancy in 34/69 patients (49%), and nondiagnostic in 9/69 patients (13%). The median follow-up time was 9 months (range 4-14 months). Twenty patients (29%) were diagnosed with malignancy (sensitivity of 75% and specificity of 78%). The procedure led to either diagnosis or treatment of 39 patients (57%). However, in 30 patients (43%), the initial cystoscopy did not aid in the diagnosis, led to misdiagnoses, or required a follow-up cystoscopy. On univariate analyses, none of the precystoscopy variables were predictive of bladder malignancy.
CONCLUSION: Flexible cystoscopy in the setting of acute hematuria requiring hospitalization did not lead to diagnosis or treatment in over 40% of cases. In this setting, consideration should be given to performing an upfront cystoscopy under anesthesia.
© 2021 The Author(s). Published by S. Karger AG, Basel.

Entities:  

Keywords:  Cystoscopy; Hematuria; Urinary bladder neoplasms; Urological diagnostic techniques

Mesh:

Year:  2021        PMID: 34284410      PMCID: PMC8985021          DOI: 10.1159/000517374

Source DB:  PubMed          Journal:  Urol Int        ISSN: 0042-1138            Impact factor:   2.089


  21 in total

1.  Patient-specific risk of undetected malignant disease after investigation for haematuria, based on a 4-year follow-up.

Authors:  Thomas J Edwards; Andrew J Dickinson; Jane Gosling; Paul D McInerney; Salvatore Natale; John S McGrath
Journal:  BJU Int       Date:  2010-08-19       Impact factor: 5.588

2.  A prospective analysis of the diagnostic yield resulting from the attendance of 4020 patients at a protocol-driven haematuria clinic.

Authors:  Tom J Edwards; Andrew J Dickinson; Salvatore Natale; Jane Gosling; John S McGrath
Journal:  BJU Int       Date:  2006-02       Impact factor: 5.588

Review 3.  The Investigation of Hematuria.

Authors:  Christian Bolenz; Bernd Schröppel; Andreas Eisenhardt; Bernd J Schmitz-Dräger; Marc-Oliver Grimm
Journal:  Dtsch Arztebl Int       Date:  2018-11-30       Impact factor: 5.594

4.  Diagnosis, evaluation and follow-up of asymptomatic microhematuria (AMH) in adults: AUA guideline.

Authors:  Rodney Davis; J Stephen Jones; Daniel A Barocas; Erik P Castle; Erich K Lang; Raymond J Leveillee; Edward M Messing; Scott D Miller; Andrew C Peterson; Thomas M T Turk; William Weitzel
Journal:  J Urol       Date:  2012-10-24       Impact factor: 7.450

5.  Mortality increases when radical cystectomy is delayed more than 12 weeks: results from a Surveillance, Epidemiology, and End Results-Medicare analysis.

Authors:  John L Gore; Julie Lai; Claude M Setodji; Mark S Litwin; Christopher S Saigal
Journal:  Cancer       Date:  2009-03-01       Impact factor: 6.860

6.  Current Standards in the Endoscopic Management of Bladder Cancer: A Survey Evaluation among Urologists in German-Speaking Countries.

Authors:  Rodrigo Suarez-Ibarrola; Simon Hein; Erik Farin; Frank Waldbillig; Maximilian C Kriegmair; Manuel Ritter; Hans C Klingler; Thomas R W Herrmann; Christian Gratzke; Arkadiusz Miernik
Journal:  Urol Int       Date:  2020-03-25       Impact factor: 2.089

7.  Association Between Use of Antithrombotic Medication and Hematuria-Related Complications.

Authors:  Christopher J D Wallis; Tristan Juvet; Yuna Lee; Rano Matta; Sender Herschorn; Ronald Kodama; Girish S Kulkarni; Raj Satkunasivam; William Geerts; Anne McLeod; Steven A Narod; Robert K Nam
Journal:  JAMA       Date:  2017-10-03       Impact factor: 56.272

Review 8.  Urinary Biomarkers in the Evaluation of Primary Hematuria: A Systematic Review and Meta-Analysis.

Authors:  Niranjan J Sathianathen; Mohit Butaney; Christopher J Weight; Raj Kumar; Badrinath R Konety
Journal:  Bladder Cancer       Date:  2018-10-29

9.  Clinical Significance of Pre-treated Neutrophil-Lymphocyte Ratio in the Management of Urothelial Carcinoma: A Systemic Review and Meta-Analysis.

Authors:  Jungyo Suh; Jae Hyun Jung; Chang Wook Jeong; Cheol Kwak; Hyeon Hoe Kim; Ja Hyeon Ku
Journal:  Front Oncol       Date:  2019-12-16       Impact factor: 6.244

10.  Macroscopic hematuria-a leading urological problem in patients on anticoagulant therapy: is the common diagnostic standard still advisable?

Authors:  Artur A Antoniewicz; Lukasz Zapała; Sławomir Poletajew; Andrzej Borówka
Journal:  ISRN Urol       Date:  2012-04-01
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