Literature DB >> 3428288

New fast preparation of 123I labelled radiopharmaceuticals.

J Mertens1, W Vanryckeghem, M Gysemans, J Eersels, E Finda-Panek, L Carlsen.   

Abstract

A new fast kit preparation of 123I labelled radiopharmaceuticals such as IMP, HIPDM, MIBG and Hippuran is proposed. A radiochemical yield greater than 99% is obtained at 100 degrees C within 10-30 min. The new labelling procedure is based on the nucleophilic exchange in presence of Cu(I) and an excess of reducing agents. The four kit prepared 123I-radiopharmaceuticals have been used with success in clinical studies involving 400 patients. The proposed method is also compared with earlier described methods which, yielding labelled side products and 123I2, do not fulfill the requirements for kit labelling.

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Year:  1987        PMID： 3428288     DOI： 10.1007/BF00253000

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  6 in total

1.  Radioiodine-labeled N,N-dimethyl-N'-(2-hydroxy-3-alkyl-5-iodobenzyl)-1,3-propanediamines for brain perfusion imaging.

Authors:  K M Tramposch; H F Kung; M Blau
Journal:  J Med Chem       Date:  1983-02       Impact factor: 7.446

2.  131I-labelled N-isopropyl-p-Iodoamphetamine.

Authors:  L Carlsen; K Andresen
Journal:  Eur J Nucl Med       Date:  1982

3.  Rapid synthesis of 123I-labeled iodinated contrast media by "kit"-type labeling procedure.

Authors:  S L Mills
Journal:  Int J Appl Radiat Isot       Date:  1982-06

4.  A study on the labeling of o-iodohippuric acid with 123I.

Authors:  D L Fortman; P J Robbins; V J Sodd
Journal:  Int J Appl Radiat Isot       Date:  1978-07

5.  A rapid quantitative method for the preparation of 123I-iodo-hippuric acid.

Authors:  L Hawkins; A Elliott; R Shields; K Herman; P Horton; W Little; C Umbers
Journal:  Eur J Nucl Med       Date:  1982

6.  Quantifying local cerebral blood flow by N-isopropyl-p-[123I]iodoamphetamine (IMP) tomography.

Authors:  D E Kuhl; J R Barrio; S C Huang; C Selin; R F Ackermann; J L Lear; J L Wu; T H Lin; M E Phelps
Journal:  J Nucl Med       Date:  1982-03       Impact factor: 10.057
  6 in total
  4 in total

Review 1.  Tracers for metabolic imaging of brain and heart. Radiochemistry and radiopharmacology.

Authors:  G Stöcklin
Journal:  Eur J Nucl Med       Date:  1992

2.  A simple and efficient method to remove free radioiodide from *I-radiopharmaceuticals.

Authors:  J L Eersels; F G Custers; G J Ensing; J D Herscheid
Journal:  Eur J Nucl Med       Date:  1995-10

3.  N-(2-diethylaminoethyl)-4-[123I]iodobenzamide as a tracer for the detection of malignant melanoma: simple synthesis, improved labelling technique and first clinical results.

Authors:  W Brandau; B Kirchner; P Bartenstein; J Sciuk; D Kamanabrou; O Schober
Journal:  Eur J Nucl Med       Date:  1993-03

4.  Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers.

Authors:  Matthias Bauwens; Marijke De Saint-Hubert; Jan Cleynhens; Laura Brams; Ellen Devos; Felix M Mottaghy; Alfons Verbruggen
Journal:  PLoS One       Date:  2012-06-13       Impact factor: 3.240
  4 in total

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