Andrew R Marley1, Ming Li2, Victoria L Champion3,4, Yiqing Song1, Jiali Han1,4, Xin Li1,4. 1. Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA. 2. Department of Epidemiology and Biostatistics, Indiana University School of Public health, Bloomington, Indiana, USA. 3. Department of Community Health Systems, Indiana University School of Nursing, Indianapolis, Indiana, USA. 4. Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana, USA.
Abstract
Background: Non-melanoma skin cancer (NMSC) incidence has been dramatically increasing worldwide. Psoralen, a known photocarcinogen, is naturally abundant in citrus products, leading to the hypothesis that high citrus consumption may increase NMSC risk. Methods: We fitted age- and multivariable-adjusted logistic regression models to evaluate the association between citrus consumption and NMSC risk among 197,372 UKBB participants. A total of 9,613 NMSC cases were identified using International Classification of Disease 10 codes. Citrus consumption data were collected via five rounds of 24-hour recall questionnaires. Results: We found no association between high total citrus consumption and NMSC risk, although a slightly elevated NMSC risk was observed among participants who consumed >0 to half a serving of total citrus per day (OR [95% CI] = 1.08 [1.01-1.16]). There was no association between individual citrus products and NMSC risk. Conclusion: High citrus consumption was not associated with an increased risk of NMSC in our UKBB sample. Further studies are needed to clarify these associations.Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1952439 .
Background: Non-melanoma skin cancer (NMSC) incidence has been dramatically increasing worldwide. Psoralen, a known photocarcinogen, is naturally abundant in citrus products, leading to the hypothesis that high citrus consumption may increase NMSC risk. Methods: We fitted age- and multivariable-adjusted logistic regression models to evaluate the association between citrus consumption and NMSC risk among 197,372 UKBB participants. A total of 9,613 NMSC cases were identified using International Classification of Disease 10 codes. Citrus consumption data were collected via five rounds of 24-hour recall questionnaires. Results: We found no association between high total citrus consumption and NMSC risk, although a slightly elevated NMSC risk was observed among participants who consumed >0 to half a serving of total citrus per day (OR [95% CI] = 1.08 [1.01-1.16]). There was no association between individual citrus products and NMSC risk. Conclusion: High citrus consumption was not associated with an increased risk of NMSC in our UKBB sample. Further studies are needed to clarify these associations.Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1952439 .
Authors: Oma N Agbai; Kesha Buster; Miguel Sanchez; Claudia Hernandez; Roopal V Kundu; Melvin Chiu; Wendy E Roberts; Zoe D Draelos; Reva Bhushan; Susan C Taylor; Henry W Lim Journal: J Am Acad Dermatol Date: 2014-01-28 Impact factor: 11.527