Marco Girolami1, Maria Sartori2, Donato Monopoli-Forleo3, Riccardo Ghermandi1, Giuseppe Tedesco1, Gisberto Evangelisti1, Valerio Pipola1, Eleonora Pesce1, Luigi Falzetti1, Milena Fini4, Alessandro Gasbarrini1. 1. Department of Oncologic and Degenerative Spine Surgery, IRCCS - Istituto Ortopedico Rizzoli, via G.C.Pupilli, 1, 40136, Bologna, Italy. 2. Surgical Sciences and Technologies Complex Structure, IRCCS - Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136, Bologna, Italy. maria.sartori@ior.it. 3. Canary Islands Institute of Technology (ITC), Canary, Spain. 4. Surgical Sciences and Technologies Complex Structure, IRCCS - Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136, Bologna, Italy.
Abstract
PURPOSE: In the present report it is described the design, the manufacturing and the successful surgical implant of one of the first 3D custom titanium vertebra realized with Additive Manufacturing technique and its use for the spinal reconstruction after en-bloc resection for primary osteogenic sarcoma. METHODS: Clinical case presentation and the design of the 3D custom titanium vertebra was reported. It was also described the complex procedures adopted to evaluate the retrieved device from the histological point of view, as a tumor relapse hit the patient, one year after the reconstruction procedure. RESULTS: The histological evaluation confirmed that the resection technique exerts an important role in promoting bone formation: vertebral body osteotomies favored the reconstruction procedure and maximized the contact area between host bone/vertebral prosthesis thus favoring the bone tissue penetration and device colonization. CONCLUSION: The sharing of these results is very important as they represent the starting point for improving the knowledge starting from the evidence obtained in a challenging clinical condition and with post-operative treatments that could be never reproduced in preclinical model.
PURPOSE: In the present report it is described the design, the manufacturing and the successful surgical implant of one of the first 3D custom titanium vertebra realized with Additive Manufacturing technique and its use for the spinal reconstruction after en-bloc resection for primary osteogenic sarcoma. METHODS: Clinical case presentation and the design of the 3D custom titanium vertebra was reported. It was also described the complex procedures adopted to evaluate the retrieved device from the histological point of view, as a tumor relapse hit the patient, one year after the reconstruction procedure. RESULTS: The histological evaluation confirmed that the resection technique exerts an important role in promoting bone formation: vertebral body osteotomies favored the reconstruction procedure and maximized the contact area between host bone/vertebral prosthesis thus favoring the bone tissue penetration and device colonization. CONCLUSION: The sharing of these results is very important as they represent the starting point for improving the knowledge starting from the evidence obtained in a challenging clinical condition and with post-operative treatments that could be never reproduced in preclinical model.
Authors: M Maglio; F Salamanna; S Brogini; V Borsari; S Pagani; N Nicoli Aldini; G Giavaresi; M Fini Journal: Biomed Res Int Date: 2020-01-17 Impact factor: 3.411
Authors: Roberta Costanzo; Gianluca Ferini; Lara Brunasso; Lapo Bonosi; Massimiliano Porzio; Umberto Emanuele Benigno; Sofia Musso; Rosa Maria Gerardi; Giuseppe Roberto Giammalva; Federica Paolini; Paolo Palmisciano; Giuseppe Emmanuele Umana; Carmelo Lucio Sturiale; Rina Di Bonaventura; Domenico Gerardo Iacopino; Rosario Maugeri Journal: Life (Basel) Date: 2022-03-28