BACKGROUND: Parathyroid hormone (PTH) is a calcium homeostasis regulator and can affect bone marrow niche. PTH leads to the bone marrow stem cell niche expansion as well as the induction of stem cell mobilization from the bone marrow into peripheral blood. In this study, we evaluated the association between pre- transplantation serum PTH levels and the number of circulating CD34+ cells along with the platelets/white blood cells (Plt/WBC) engraftment in patients who underwent autologous Hematopoietic Stem Cell Transplantation. METHODS: Subjects for the study were 100 patients who received autologous hematopoietic stem cell transplantation (auto-HSCT), retrospectively. Serum levels of PTH, calcium, phosphorus, and alkaline phosphatase were measured before mobilization. Their impacts were measured on the number of mobilized CD34+ hematopoietic stem cells, and Plt/WBC engraftment. RESULTS: High levels of serum PTH (> 63.10 pg/mL) was significantly associated with higher number of CD34+ cells in peripheral blood after granulocyte- colony stimulating factor (G-CSF)-induced mobilization (p= 0.079*). Serum calcium at low levels were associated with higher number of circulating CD34+ cells post mobilization. Pre- transplantation serum levels of phosphorus and alkaline phosphatase on CD34+ numbers were not statistically significant. Serum Plt/WBC engraftment was not improved in presence of high levels of serum PTH. CONCLUSION: We suggested that serum PTH levels before transplantation could be influential in raising the number of circulating CD34+ hematopoietic stem cell after mobilization.
BACKGROUND: Parathyroid hormone (PTH) is a calcium homeostasis regulator and can affect bone marrow niche. PTH leads to the bone marrow stem cell niche expansion as well as the induction of stem cell mobilization from the bone marrow into peripheral blood. In this study, we evaluated the association between pre- transplantation serum PTH levels and the number of circulating CD34+ cells along with the platelets/white blood cells (Plt/WBC) engraftment in patients who underwent autologous Hematopoietic Stem Cell Transplantation. METHODS: Subjects for the study were 100 patients who received autologous hematopoietic stem cell transplantation (auto-HSCT), retrospectively. Serum levels of PTH, calcium, phosphorus, and alkaline phosphatase were measured before mobilization. Their impacts were measured on the number of mobilized CD34+ hematopoietic stem cells, and Plt/WBC engraftment. RESULTS: High levels of serum PTH (> 63.10 pg/mL) was significantly associated with higher number of CD34+ cells in peripheral blood after granulocyte- colony stimulating factor (G-CSF)-induced mobilization (p= 0.079*). Serum calcium at low levels were associated with higher number of circulating CD34+ cells post mobilization. Pre- transplantation serum levels of phosphorus and alkaline phosphatase on CD34+ numbers were not statistically significant. Serum Plt/WBC engraftment was not improved in presence of high levels of serum PTH. CONCLUSION: We suggested that serum PTH levels before transplantation could be influential in raising the number of circulating CD34+ hematopoietic stem cell after mobilization.
Authors: Karen Ballen; Adam M Mendizabal; Corey Cutler; Ioannis Politikos; Katarzyna Jamieson; Elizabeth J Shpall; Bimalangshu R Dey; Eyal Attar; Steven McAfee; Colleen Delaney; Philip McCarthy; Edward D Ball; Ram Kamble; David Avigan; Richard T Maziarz; Vincent T Ho; John Koreth; Edwin Alyea; Robert Soiffer; John R Wingard; Vicki Boussiotis; Thomas R Spitzer; Joseph H Antin Journal: Biol Blood Marrow Transplant Date: 2012-07-02 Impact factor: 5.742
Authors: Stefan Brunner; Hans Diogenes Theiss; Alfons Murr; Thomas Negele; Wolfgang-Michael Franz Journal: Am J Physiol Endocrinol Metab Date: 2007-10-02 Impact factor: 4.310
Authors: Karen K Ballen; Elizabeth J Shpall; David Avigan; Beow Y Yeap; David C Fisher; Kathleen McDermott; Bimalangshu R Dey; Eyal Attar; Steven McAfee; Marina Konopleva; Joseph H Antin; Thomas R Spitzer Journal: Biol Blood Marrow Transplant Date: 2007-04-30 Impact factor: 5.742
Authors: Jau-Yi Li; Jonathan Adams; Laura M Calvi; Timothy F Lane; Richard DiPaolo; M Neale Weitzmann; Roberto Pacifici Journal: Blood Date: 2012-09-05 Impact factor: 22.113