Literature DB >> 34277235

Lipoid Proteinosis Masquerading as Seborrheic Dermatitis.

Alka Tripathi1, Sunil Kumar Gupta2.   

Abstract

We report a case of lipoid proteinosis (LP) masquerading as seborrheic dermatitis. A 35-year-old female presented to our outpatient department with complaints of itching and crust-like formation on eyelids for five years. She was treated as a case of seborrheic dermatitis elsewhere and got intermittent relief in itching with medications. Beaded lesions were found along the upper and lower eyelids involving the lash line and caruncle on removing the crust. The verrucous lesions were pathognomonic, moniliform blepharosis of LP. Systemic examination revealed hoarseness of voice, and hyperkeratosis was seen on the dorsum of both of her hands. She has been advised lid hygiene, artificial tears, and antihistaminics for itching. Skin emollients were also advised by dermatologists to decrease the chances of abrasion and bleeding from minor trauma. She was well explained about the danger signs as well as neurological and psychiatric implications of the disease. Although ophthalmologists have a rare encounter with this disease, LP is a well-known entity to dermatologists and otorhinolaryngologists, and thus it may sometimes go undiagnosed. An ophthalmologist should be well aware of the life-threatening complications associated with LP, and patients should be sensitized regarding the chronic nature, supportive measures, and danger signs of the disease.
Copyright © 2021, Tripathi et al.

Entities:  

Keywords:  ecm1 gene; lipoid proteinosis (lp); moniliform blepharosis; pathognomonic; seborrheic dermatitis

Year:  2021        PMID: 34277235      PMCID: PMC8276531          DOI: 10.7759/cureus.15617

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  10 in total

1.  HYALINOSIS CUTIS ET MUCOSAE. (LIPOIDPROTEINOSIS URBACH-WIETHE).

Authors:  J C GROSFELD; J SPAAS; W J VAN DE STAAK; A M STADHOUDERS
Journal:  Dermatologica       Date:  1965

2.  Lipoid proteinosis (Urbach-Wiethe disease): a case report from India.

Authors:  Kadambari Batra; Anil Safaya; Kiran Aggarwal
Journal:  Ear Nose Throat J       Date:  2008-09       Impact factor: 1.697

Review 3.  Lipoid proteinosis: case report and review of the literature.

Authors:  S Di Giandomenico; R Masi; D Cassandrini; M El-Hachem; R De Vito; C Bruno; F M Santorelli
Journal:  Acta Otorhinolaryngol Ital       Date:  2006-06       Impact factor: 2.124

4.  Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1).

Authors:  Takahiro Hamada; W H Irwin McLean; Michele Ramsay; Gabrielle H S Ashton; Arti Nanda; Trefor Jenkins; Isobel Edelstein; Andrew P South; Oliver Bleck; Vesarat Wessagowit; Rajeev Mallipeddi; Guy E Orchard; Hong Wan; Patricia J C Dopping-Hepenstal; Jemima E Mellerio; Neil V Whittock; Colin S Munro; Maurice A M van Steensel; Peter M Steijlen; Jian Ni; Lurong Zhang; Takashi Hashimoto; Robin A J Eady; John A McGrath
Journal:  Hum Mol Genet       Date:  2002-04-01       Impact factor: 6.150

Review 5.  Subepidermal Calcinosis in the Ocular Adnexa: A Systematic Review.

Authors:  Kay T Khine; Dallas S Shi; Ashlie Bernhisel; Kevin R Gertsch; Nick Mamalis; Bhupendra C K Patel; Jonathan J Dutton
Journal:  Ophthalmic Plast Reconstr Surg       Date:  2018 Mar/Apr       Impact factor: 1.746

6.  Keratoconus in a case of lipoid proteinosis.

Authors:  Ugur Acar; Elvin H Yildiz; Dilek Yuksel; Huseyin Ustun; Nurten Unlu
Journal:  Eye Contact Lens       Date:  2013-07       Impact factor: 2.018

7.  Urbach-wiethe syndrome and the ophthalmologist: review of the literature and introduction of the first instance of bilateral uveitis.

Authors:  Seyed-Mojtaba Abtahi; Farzan Kianersi; Mohammad-Ali Abtahi; Seyed-Hossein Abtahi; Arash Zahed; Hamid-Reza Fesharaki; Zahra-Alsadat Abtahi; Shahzad Baradaran; Mehdi Mazloumi; Saeed Naghiabadi
Journal:  Case Rep Med       Date:  2012-07-31

8.  Lipoid proteinosis.

Authors:  Roopa Shamsundar Rao; Sunita S Betkerur; Chaitanya Babu; Vm Sudha
Journal:  J Oral Maxillofac Pathol       Date:  2009-07

9.  Lipoid proteinosis: A rare entity.

Authors:  Bipasha Mukherjee; Pratheeba N Devi
Journal:  Indian J Ophthalmol       Date:  2015-08       Impact factor: 1.848

10.  A Rare Case of Amyloidosis of the Eyelid and Conjunctiva.

Authors:  Zaria Ali; Bertie Fernando
Journal:  Case Rep Ophthalmol Med       Date:  2016-09-26
  10 in total
  1 in total

Review 1.  Lipoid proteinosis: Review of Indian cases.

Authors:  Jigna S Shah; Himali A Shah
Journal:  J Oral Maxillofac Pathol       Date:  2022-06-28
  1 in total

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