Literature DB >> 34276331

Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease.

Jhielson M Pimentel1, Renan C Moioli2, Mariana F P de Araujo3, Caetano M Ranieri4, Roseli A F Romero4, Frank Broz1, Patricia A Vargas1.   

Abstract

In this work, we present the first steps toward the creation of a new neurorobotics model of Parkinson's Disease (PD) that embeds, for the first time in a real robot, a well-established computational model of PD. PD mostly affects the modulation of movement in humans. The number of people suffering from this neurodegenerative disease is set to double in the next 15 years and there is still no cure. With the new model we were capable to further explore the dynamics of the disease using a humanoid robot. Results show that the embedded model under both conditions, healthy and parkinsonian, was capable of performing a simple behavioural task with different levels of motor disturbance. We believe that this neurorobotics model is a stepping stone to the development of more sophisticated models that could eventually test and inform new PD therapies and help to reduce and replace animals in research.
Copyright © 2021 Pimentel, Moioli, de Araujo, Ranieri, Romero, Broz and Vargas.

Entities:  

Keywords:  Parkinson's disease; basal ganglia; motor control; motor cortex; neurorobotics; robot controller

Year:  2021        PMID: 34276331      PMCID: PMC8283825          DOI: 10.3389/fnbot.2021.640449

Source DB:  PubMed          Journal:  Front Neurorobot        ISSN: 1662-5218            Impact factor:   2.650


  70 in total

Review 1.  Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway.

Authors:  Atsushi Nambu; Hironobu Tokuno; Masahiko Takada
Journal:  Neurosci Res       Date:  2002-06       Impact factor: 3.304

2.  Cueing training in the home improves gait-related mobility in Parkinson's disease: the RESCUE trial.

Authors:  A Nieuwboer; G Kwakkel; L Rochester; D Jones; E van Wegen; A M Willems; F Chavret; V Hetherington; K Baker; I Lim
Journal:  J Neurol Neurosurg Psychiatry       Date:  2007-02       Impact factor: 10.154

3.  A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson's disease.

Authors:  Karthik Kumaravelu; David T Brocker; Warren M Grill
Journal:  J Comput Neurosci       Date:  2016-02-11       Impact factor: 1.621

Review 4.  Insights into Parkinson's disease from computational models of the basal ganglia.

Authors:  Mark D Humphries; Jose Angel Obeso; Jakob Kisbye Dreyer
Journal:  J Neurol Neurosurg Psychiatry       Date:  2018-04-17       Impact factor: 10.154

5.  Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats.

Authors:  Rosa Q So; George C McConnell; Auriel T August; Warren M Grill
Journal:  IEEE Trans Neural Syst Rehabil Eng       Date:  2012-06-06       Impact factor: 3.802

Review 6.  The cortico-basal ganglia integrative network: the role of the thalamus.

Authors:  Suzanne N Haber; Roberta Calzavara
Journal:  Brain Res Bull       Date:  2008-10-23       Impact factor: 4.077

7.  High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model.

Authors:  Jonathan E Rubin; David Terman
Journal:  J Comput Neurosci       Date:  2004 May-Jun       Impact factor: 1.621

8.  The cerebral oscillatory network of voluntary tremor.

Authors:  Bettina Pollok; Joachim Gross; Martin Dirks; Lars Timmermann; Alfons Schnitzler
Journal:  J Physiol       Date:  2003-11-28       Impact factor: 5.182

9.  Neurorobotics: an experimental science of embodiment.

Authors:  Frederic Kaplan
Journal:  Front Neurosci       Date:  2008-08-01       Impact factor: 4.677

10.  Theta oscillations locked to intended actions rhythmically modulate perception.

Authors:  Alice Tomassini; Luca Ambrogioni; W Pieter Medendorp; Eric Maris
Journal:  Elife       Date:  2017-07-07       Impact factor: 8.140

View more
  1 in total

1.  Modernizing the NEURON Simulator for Sustainability, Portability, and Performance.

Authors:  Omar Awile; Pramod Kumbhar; Nicolas Cornu; Salvador Dura-Bernal; James Gonzalo King; Olli Lupton; Ioannis Magkanaris; Robert A McDougal; Adam J H Newton; Fernando Pereira; Alexandru Săvulescu; Nicholas T Carnevale; William W Lytton; Michael L Hines; Felix Schürmann
Journal:  Front Neuroinform       Date:  2022-06-27       Impact factor: 3.739

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.