| Literature DB >> 34274498 |
Tânia D F Costa1, Staffan Strömblad2.
Abstract
Understanding why proteins are overexpressed in cancer is of great interest, as it holds the potential for improved cancer diagnosis and treatment. A noteworthy candidate, p21-activated kinase 4 (PAK4), is frequently overexpressed in cancer and a key player in multiple hallmarks of cancer. Here we review findings backing PAK4 overexpression in cancer and motivate PAK4 as a suitable target for the development of cancer therapy.Entities:
Keywords: Cancer; Cellular senescence; Protein overexpression; p21-activated kinase
Year: 2021 PMID： 34274498 DOI： 10.1016/j.biocel.2021.106041
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085