Literature DB >> 34274486

Breast cancer heterogeneity through the lens of single-cell analysis and spatial pathologies.

Na Zhao1, Jeffrey M Rosen2.   

Abstract

Breast cancer ecosystems are composed of complex cell types, including tumor, stromal and immune cells, each of which can assume diverse phenotypes. Both the heterogeneous composition and spatially distinct tumor microenvironment impact breast cancer progression, treatment response and therapeutic resistance. Thus, a deeper understanding of breast cancer heterogeneity may help facilitate the development of novel therapies and improve outcomes for patients. The advent of paradigm shifting single-cell analysis and spatial pathologies allows for a comprehensive analysis of the tumor ecosystem as well as the interactions between its components at unprecedented resolution. In this review, we discuss the insights gained through single-cell analysis and spatial pathologies on breast cancer heterogeneity.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Breast cancer; Single-cell; Spatial pathology; Tumor heterogeneity; Tumor microenvironment

Mesh：

Year:  2021        PMID： 34274486      PMCID： PMC8761219          DOI： 10.1016/j.semcancer.2021.07.010

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   17.012


  96 in total

1.  A pathway-based classification of human breast cancer.

Authors:  Michael L Gatza; Joseph E Lucas; William T Barry; Jong Wook Kim; Quanli Wang; Matthew D Crawford; Michael B Datto; Michael Kelley; Bernard Mathey-Prevot; Anil Potti; Joseph R Nevins
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2.  High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer.

Authors:  Kevin Grosselin; Adeline Durand; Justine Marsolier; Adeline Poitou; Elisabetta Marangoni; Fariba Nemati; Ahmed Dahmani; Sonia Lameiras; Fabien Reyal; Olivia Frenoy; Yannick Pousse; Marcel Reichen; Adam Woolfe; Colin Brenan; Andrew D Griffiths; Céline Vallot; Annabelle Gérard
Journal:  Nat Genet       Date:  2019-05-31       Impact factor: 38.330

3.  Multiplexed ion beam imaging of human breast tumors.

Authors:  Michael Angelo; Sean C Bendall; Rachel Finck; Matthew B Hale; Chuck Hitzman; Alexander D Borowsky; Richard M Levenson; John B Lowe; Scot D Liu; Shuchun Zhao; Yasodha Natkunam; Garry P Nolan
Journal:  Nat Med       Date:  2014-03-02       Impact factor: 53.440

4.  Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.

Authors:  Peter Schmid; Sylvia Adams; Hope S Rugo; Andreas Schneeweiss; Carlos H Barrios; Hiroji Iwata; Véronique Diéras; Roberto Hegg; Seock-Ah Im; Gail Shaw Wright; Volkmar Henschel; Luciana Molinero; Stephen Y Chui; Roel Funke; Amreen Husain; Eric P Winer; Sherene Loi; Leisha A Emens
Journal:  N Engl J Med       Date:  2018-10-20       Impact factor: 91.245

5.  The single-cell pathology landscape of breast cancer.

Authors:  Hartland W Jackson; Jana R Fischer; Vito R T Zanotelli; H Raza Ali; Robert Mechera; Savas D Soysal; Holger Moch; Simone Muenst; Zsuzsanna Varga; Walter P Weber; Bernd Bodenmiller
Journal:  Nature       Date:  2020-01-20       Impact factor: 49.962

6.  The evolutionary history of 2,658 cancers.

Authors:  Moritz Gerstung; Clemency Jolly; Ignaty Leshchiner; Stefan C Dentro; Santiago Gonzalez; Daniel Rosebrock; Thomas J Mitchell; Yulia Rubanova; Pavana Anur; Kaixian Yu; Maxime Tarabichi; Amit Deshwar; Jeff Wintersinger; Kortine Kleinheinz; Ignacio Vázquez-García; Kerstin Haase; Lara Jerman; Subhajit Sengupta; Geoff Macintyre; Salem Malikic; Nilgun Donmez; Dimitri G Livitz; Marek Cmero; Jonas Demeulemeester; Steven Schumacher; Yu Fan; Xiaotong Yao; Juhee Lee; Matthias Schlesner; Paul C Boutros; David D Bowtell; Hongtu Zhu; Gad Getz; Marcin Imielinski; Rameen Beroukhim; S Cenk Sahinalp; Yuan Ji; Martin Peifer; Florian Markowetz; Ville Mustonen; Ke Yuan; Wenyi Wang; Quaid D Morris; Paul T Spellman; David C Wedge; Peter Van Loo
Journal:  Nature       Date:  2020-02-06       Impact factor: 49.962

7.  The human body at cellular resolution: the NIH Human Biomolecular Atlas Program.

Authors: 
Journal:  Nature       Date:  2019-10-09       Impact factor: 69.504

8.  Breast tumours maintain a reservoir of subclonal diversity during expansion.

Authors:  Darlan C Minussi; Michael D Nicholson; Hanghui Ye; Alexander Davis; Kaile Wang; Toby Baker; Maxime Tarabichi; Emi Sei; Haowei Du; Mashiat Rabbani; Cheng Peng; Min Hu; Shanshan Bai; Yu-Wei Lin; Aislyn Schalck; Asha Multani; Jin Ma; Thomas O McDonald; Anna Casasent; Angelica Barrera; Hui Chen; Bora Lim; Banu Arun; Funda Meric-Bernstam; Peter Van Loo; Franziska Michor; Nicholas E Navin
Journal:  Nature       Date:  2021-03-24       Impact factor: 69.504

9.  Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling.

Authors:  Susanne Nichterwitz; Geng Chen; Julio Aguila Benitez; Marlene Yilmaz; Helena Storvall; Ming Cao; Rickard Sandberg; Qiaolin Deng; Eva Hedlund
Journal:  Nat Commun       Date:  2016-07-08       Impact factor: 14.919

10.  The Human Cell Atlas.

Authors:  Aviv Regev; Sarah A Teichmann; Eric S Lander; Ido Amit; Christophe Benoist; Ewan Birney; Bernd Bodenmiller; Peter Campbell; Piero Carninci; Menna Clatworthy; Hans Clevers; Bart Deplancke; Ian Dunham; James Eberwine; Roland Eils; Wolfgang Enard; Andrew Farmer; Lars Fugger; Berthold Göttgens; Nir Hacohen; Muzlifah Haniffa; Martin Hemberg; Seung Kim; Paul Klenerman; Arnold Kriegstein; Ed Lein; Sten Linnarsson; Emma Lundberg; Joakim Lundeberg; Partha Majumder; John C Marioni; Miriam Merad; Musa Mhlanga; Martijn Nawijn; Mihai Netea; Garry Nolan; Dana Pe'er; Anthony Phillipakis; Chris P Ponting; Stephen Quake; Wolf Reik; Orit Rozenblatt-Rosen; Joshua Sanes; Rahul Satija; Ton N Schumacher; Alex Shalek; Ehud Shapiro; Padmanee Sharma; Jay W Shin; Oliver Stegle; Michael Stratton; Michael J T Stubbington; Fabian J Theis; Matthias Uhlen; Alexander van Oudenaarden; Allon Wagner; Fiona Watt; Jonathan Weissman; Barbara Wold; Ramnik Xavier; Nir Yosef
Journal:  Elife       Date:  2017-12-05       Impact factor: 8.140
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  6 in total

1.  A Novel YTHDF3-Based Model to Predict Prognosis and Therapeutic Response in Breast Cancer.

Authors:  Jie Liu; Jing Zhu; Xin Wang; Zhisheng Zhou; Haiyan Liu; Dajiang Zhu
Journal:  Front Mol Biosci       Date:  2022-06-09

2.  High AUF1 level in stromal fibroblasts promotes carcinogenesis and chemoresistance and predicts unfavorable prognosis among locally advanced breast cancer patients.

Authors:  Taher Al-Tweigeri; Noura N AlRaouji; Asma Tulbah; Maria Arafah; Mouad Aboussekhra; Falah Al-Mohanna; Ahmed Mostafa Gad; Abdelmonneim M Eldali; Tusneem A Elhassan; Abdelilah Aboussekhra
Journal:  Breast Cancer Res       Date:  2022-07-11       Impact factor: 8.408

3.  Cancer cell heterogeneity and plasticity: From molecular understanding to therapeutic targeting.

Authors:  Dean G Tang; Toru Kondo
Journal:  Semin Cancer Biol       Date:  2021-10-06       Impact factor: 17.012

4.  Pyroptosis-related molecular classification and immune microenvironment infiltration in breast cancer: A novel therapeutic target.

Authors:  Jiayue Luo; Jianguo Lai
Journal:  J Cell Mol Med       Date:  2022-03-01       Impact factor: 5.310

Review 5.  Predictive Biomarkers of Response to Neoadjuvant Chemotherapy in Breast Cancer: Current and Future Perspectives for Precision Medicine.

Authors:  Françoise Derouane; Cédric van Marcke; Martine Berlière; Amandine Gerday; Latifa Fellah; Isabelle Leconte; Mieke R Van Bockstal; Christine Galant; Cyril Corbet; Francois P Duhoux
Journal:  Cancers (Basel)       Date:  2022-08-11       Impact factor: 6.575

6.  Identification of cuproptosis-related patterns and construction of a scoring system for predicting prognosis, tumor microenvironment-infiltration characteristics, and immunotherapy efficacy in breast cancer.

Authors:  Wei Li; Xingda Zhang; Yanbo Chen; Da Pang
Journal:  Front Oncol       Date:  2022-09-23       Impact factor: 5.738
  6 in total

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