Martina Votto1, Alessandro Raffaele2, Maria De Filippo1, Silvia Caimmi3, Marco Brunero2, Giovanna Riccipetitoni4, Gian Luigi Marseglia1, Amelia Licari5. 1. Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. 2. Pediatric Surgery Unit, Department of Maternal and Child Health, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 3. Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 4. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Pediatric Surgery Unit, Department of Maternal and Child Health, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 5. Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. Electronic address: amelia.licari@unipv.it.
Abstract
BACKGROUND: To date, few studies have been conducted in Italy on pediatric eosinophilic gastrointestinal diseases (EGIDs). AIMS: To assess clinical features of pediatric patients with EGIDs who are followed in a tertiary pediatric center. METHODS: From January 2015 to December 2019, we retrospectively enrolled patients with EGIDs, and collected clinical, endoscopic, and histological data. RESULTS: We enrolled 112 patients, 75.8% were male. Mean age was 9.3 ± 4.8 years. Diagnosis of EGIDs has increased in the last two years, with non-esophageal EGIDs more prevalent than eosinophilic esophagitis (EoE) (5.1% vs. 4.4%). Approximately 30% of patients had allergic comorbidities, which prevailed in children with EoE. Autism spectrum disorders were common in patients with non-esophageal EGIDs (p = 0.007), a statistically significant finding. In addition, esophageal atresia was associated with EoE (p = 0.04). Most EGIDs patients had normal findings or an inflammatory endoscopic phenotype. Patients with EoE were mainly treated with proton pump inhibitors (PPIs) alone or in combination with swallowed steroids. PPIs, oral steroids, and food-elimination diets were prescribed to patients with non-esophageal EGIDs. CONCLUSION: This is the first Italian study revealing an increased frequency of EGIDs in a pediatric population. Further studies are needed to characterize patients with these emerging diseases.
BACKGROUND: To date, few studies have been conducted in Italy on pediatric eosinophilic gastrointestinal diseases (EGIDs). AIMS: To assess clinical features of pediatric patients with EGIDs who are followed in a tertiary pediatric center. METHODS: From January 2015 to December 2019, we retrospectively enrolled patients with EGIDs, and collected clinical, endoscopic, and histological data. RESULTS: We enrolled 112 patients, 75.8% were male. Mean age was 9.3 ± 4.8 years. Diagnosis of EGIDs has increased in the last two years, with non-esophageal EGIDs more prevalent than eosinophilic esophagitis (EoE) (5.1% vs. 4.4%). Approximately 30% of patients had allergic comorbidities, which prevailed in children with EoE. Autism spectrum disorders were common in patients with non-esophageal EGIDs (p = 0.007), a statistically significant finding. In addition, esophageal atresia was associated with EoE (p = 0.04). Most EGIDs patients had normal findings or an inflammatory endoscopic phenotype. Patients with EoE were mainly treated with proton pump inhibitors (PPIs) alone or in combination with swallowed steroids. PPIs, oral steroids, and food-elimination diets were prescribed to patients with non-esophageal EGIDs. CONCLUSION: This is the first Italian study revealing an increased frequency of EGIDs in a pediatric population. Further studies are needed to characterize patients with these emerging diseases.
Authors: Carlo Maria Rossi; Marco Vincenzo Lenti; Stefania Merli; Amelia Licari; Martina Votto; Gian Luigi Marseglia; Antonio Di Sabatino Journal: Clin Transl Allergy Date: 2022-05-23 Impact factor: 5.657
Authors: Martina Votto; Maria De Filippo; Marco Vincenzo Lenti; Carlo Maria Rossi; Antonio Di Sabatino; Gian Luigi Marseglia; Amelia Licari Journal: Front Pediatr Date: 2022-01-20 Impact factor: 3.418
Authors: Martina Votto; Matteo Naso; Andrea Martina Clemente; Maria De Filippo; Ginevra Gargiulo; Veronica Granone; Giulia Siri; Gian Luigi Marseglia; Amelia Licari Journal: Acta Biomed Date: 2022-06-06