Literature DB >> 34272692

Multienzyme Kinetics and Sequential Metabolism.

Larry C Wienkers1, Brooke M Rock2.   

Abstract

Enzymes are the catalysts of biological systems and are extremely efficient. A typical enzyme accelerates the rate of a reaction by factors of at least a million compared to the rate of the same reaction in the absence of the enzyme. In contrast to traditional catalytic enzymes, the family of cytochrome P450 (CYPs) enzymes are catalytically promiscuous and thus they possess remarkable versatility in substrates. The great diversity of reactions catalyzed by CYP enzymes appear to be based on two unique properties of these heme proteins, the ability of their iron to exist under multiple oxidation states with different reactivities and a flexible active site that can accommodate a wide variety of substrates. Herein, is a discussion of two distinct type of kinetics observed with CYP enzymes. The first example is of CYP complex kinetic profiles when multiple CYP enzymes form the sample product. The second is sequential metabolism, in other words, the formation of multiple products from one CYP enzyme. Given the degree of CYP enzyme promiscuity, it is hardly surprising that there is also a high degree of complex kinetic profiles generated during the catalytic cycle.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  CYP enzymes; Drug metabolism; Enzyme kinetics; Mechanism-based inhibition; Sequential metabolism

Year:  2021        PMID: 34272692     DOI: 10.1007/978-1-0716-1554-6_4

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  50 in total

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Authors:  Larry C Wienkers; Timothy G Heath
Journal:  Nat Rev Drug Discov       Date:  2005-10       Impact factor: 84.694

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Journal:  Methods Enzymol       Date:  1996       Impact factor: 1.600

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Authors:  W J Albery; J R Knowles
Journal:  Biochemistry       Date:  1976-12-14       Impact factor: 3.162

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Authors:  G E Lienhard
Journal:  Science       Date:  1973-04-15       Impact factor: 47.728

10.  What factors affect the regioselectivity of oxidation by cytochrome p450? A DFT study of allylic hydroxylation and double bond epoxidation in a model reaction.

Authors:  Sam P de Visser; François Ogliaro; Pankaz K Sharma; Sason Shaik
Journal:  J Am Chem Soc       Date:  2002-10-02       Impact factor: 15.419

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