Literature DB >> 34272086

HIV vaccinology: 2021 update.

Jeong Hyun Lee1, Shane Crotty2.   

Abstract

HIV is a virus that remains a major health concern and results in an infection that has no cure even after over 30 years since its discovery. As such, HIV vaccine discovery continues to be an area of intensive research. In this review, we summarize the most recent HIV vaccine efficacy trials, clinical trials initiated within the last 3 years, and discuss prominent improvements that have been made in prophylactic HIV vaccine designs.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Broadly neutralizing antibodies; Human immunodeficiency virus; Review; Vaccine

Mesh：

Substances：

Year:  2021        PMID： 34272086      PMCID： PMC8463426          DOI： 10.1016/j.smim.2021.101470

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   10.671


  215 in total

1.  HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity.

Authors:  Mark K Louder; Anna Sambor; Elena Chertova; Tai Hunte; Sarah Barrett; Fallon Ojong; Eric Sanders-Buell; Susan Zolla-Pazner; Francine E McCutchan; James D Roser; Dana Gabuzda; Jeffrey D Lifson; John R Mascola
Journal:  Virology       Date:  2005-09-01       Impact factor: 3.616

2.  HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.

Authors:  Joseph G Jardine; Daniel W Kulp; Colin Havenar-Daughton; Anita Sarkar; Bryan Briney; Devin Sok; Fabian Sesterhenn; June Ereño-Orbea; Oleksandr Kalyuzhniy; Isaiah Deresa; Xiaozhen Hu; Skye Spencer; Meaghan Jones; Erik Georgeson; Yumiko Adachi; Michael Kubitz; Allan C deCamp; Jean-Philippe Julien; Ian A Wilson; Dennis R Burton; Shane Crotty; William R Schief
Journal:  Science       Date:  2016-03-25       Impact factor: 47.728

3.  Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions.

Authors:  S Moses Dennison; Shelley M Stewart; Kathryn C Stempel; Hua-Xin Liao; Barton F Haynes; S Munir Alam
Journal:  J Virol       Date:  2009-07-29       Impact factor: 5.103

4.  Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

Authors:  Fernando Garces; Jeong Hyun Lee; Natalia de Val; Alba Torrents de la Pena; Leopold Kong; Cristina Puchades; Yuanzi Hua; Robyn L Stanfield; Dennis R Burton; John P Moore; Rogier W Sanders; Andrew B Ward; Ian A Wilson
Journal:  Immunity       Date:  2015-12-15       Impact factor: 31.745

5.  Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.

Authors:  Hannah J Barbian; Julie M Decker; Frederic Bibollet-Ruche; Rachel P Galimidi; Anthony P West; Gerald H Learn; Nicholas F Parrish; Shilpa S Iyer; Yingying Li; Craig S Pace; Ruijiang Song; Yaoxing Huang; Thomas N Denny; Hugo Mouquet; Loic Martin; Priyamvada Acharya; Baoshan Zhang; Peter D Kwong; John R Mascola; C Theo Verrips; Nika M Strokappe; Lucy Rutten; Laura E McCoy; Robin A Weiss; Corrine S Brown; Raven Jackson; Guido Silvestri; Mark Connors; Dennis R Burton; George M Shaw; Michel C Nussenzweig; Pamela J Bjorkman; David D Ho; Michael Farzan; Beatrice H Hahn
Journal:  MBio       Date:  2015-04-21       Impact factor: 7.867

6.  Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.

Authors:  Daniel W Kulp; Jon M Steichen; Matthias Pauthner; Xiaozhen Hu; Torben Schiffner; Alessia Liguori; Christopher A Cottrell; Colin Havenar-Daughton; Gabriel Ozorowski; Erik Georgeson; Oleksandr Kalyuzhniy; Jordan R Willis; Michael Kubitz; Yumiko Adachi; Samantha M Reiss; Mia Shin; Natalia de Val; Andrew B Ward; Shane Crotty; Dennis R Burton; William R Schief
Journal:  Nat Commun       Date:  2017-11-21       Impact factor: 14.919

7.  An MPER antibody neutralizes HIV-1 using germline features shared among donors.

Authors:  Lei Zhang; Adriana Irimia; Lingling He; Elise Landais; Kimmo Rantalainen; Daniel P Leaman; Thomas Vollbrecht; Armando Stano; Daniel I Sands; Arthur S Kim; Pascal Poignard; Dennis R Burton; Ben Murrell; Andrew B Ward; Jiang Zhu; Ian A Wilson; Michael B Zwick
Journal:  Nat Commun       Date:  2019-11-26       Impact factor: 14.919

8.  Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.

Authors:  Ming Tian; Cheng Cheng; Xuejun Chen; Hongying Duan; Hwei-Ling Cheng; Mai Dao; Zizhang Sheng; Michael Kimble; Lingshu Wang; Sherry Lin; Stephen D Schmidt; Zhou Du; M Gordon Joyce; Yiwei Chen; Brandon J DeKosky; Yimin Chen; Erica Normandin; Elizabeth Cantor; Rita E Chen; Nicole A Doria-Rose; Yi Zhang; Wei Shi; Wing-Pui Kong; Misook Choe; Amy R Henry; Farida Laboune; Ivelin S Georgiev; Pei-Yi Huang; Suvi Jain; Andrew T McGuire; Eric Georgeson; Sergey Menis; Daniel C Douek; William R Schief; Leonidas Stamatatos; Peter D Kwong; Lawrence Shapiro; Barton F Haynes; John R Mascola; Frederick W Alt
Journal:  Cell       Date:  2016-09-08       Impact factor: 41.582

9.  A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of Electroporated HIV DNA with or without Interleukin 12 in Prime-Boost Combinations with an Ad35 HIV Vaccine in Healthy HIV-Seronegative African Adults.

Authors:  Juliet Mpendo; Gaudensia Mutua; Julien Nyombayire; Rosine Ingabire; Annet Nanvubya; Omu Anzala; Etienne Karita; Peter Hayes; Jakub Kopycinski; Len Dally; Drew Hannaman; Michael A Egan; John H Eldridge; Kristen Syvertsen; Jennifer Lehrman; Beth Rasmussen; Jill Gilmour; Josephine H Cox; Patricia E Fast; Claudia Schmidt
Journal:  PLoS One       Date:  2015-08-07       Impact factor: 3.240

10.  Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.

Authors:  Torben Schiffner; Jesper Pallesen; Rebecca A Russell; Jonathan Dodd; Natalia de Val; Celia C LaBranche; David Montefiori; Georgia D Tomaras; Xiaoying Shen; Scarlett L Harris; Amin E Moghaddam; Oleksandr Kalyuzhniy; Rogier W Sanders; Laura E McCoy; John P Moore; Andrew B Ward; Quentin J Sattentau
Journal:  PLoS Pathog       Date:  2018-05-10       Impact factor: 6.823
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  6 in total

1.  Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding.

Authors:  Kim-Marie A Dam; Patricia S Mutia; Pamela J Bjorkman
Journal:  Sci Rep       Date:  2022-07-01       Impact factor: 4.996

2.  Chemoenzymatic Synthesis and Antibody Binding of HIV-1 V1/V2 Glycopeptide-Bacteriophage Qβ Conjugates as a Vaccine Candidate.

Authors:  Guanghui Zong; Christian Toonstra; Qiang Yang; Roushu Zhang; Lai-Xi Wang
Journal:  Int J Mol Sci       Date:  2021-11-21       Impact factor: 5.923

3.  V2 hotspot optimized MVA vaccine expressing stabilized HIV-1 Clade C envelope Gp140 delays acquisition of heterologous Clade C Tier 2 challenges in Mamu-A*01 negative Rhesus Macaques.

Authors:  Tiffany M Styles; Sailaja Gangadhara; Pradeep B J Reddy; Anusmita Sahoo; Ayalensh Shiferaw; Sarah Welbourn; Pamela A Kozlowski; Cynthia A Derdeyn; Vijayakumar Velu; Rama Rao Amara
Journal:  Front Immunol       Date:  2022-07-22       Impact factor: 8.786

4.  Vaccine-Induced Seroreactivity Impacts the Accuracy of HIV Testing Algorithms in Sub-Saharan Africa: An Exploratory Study.

Authors:  Frank Msafiri; Alice Manjate; Sarah Lindroth; Nelson Tembe; Raquel Matavele Chissumba; Victoria Cumbane; Ilesh Jani; Said Aboud; Eligius Lyamuya; Sören Andersson; Charlotta Nilsson
Journal:  Vaccines (Basel)       Date:  2022-07-01

5.  Long-primed germinal centres with enduring affinity maturation and clonal migration.

Authors:  Jeong Hyun Lee; Henry J Sutton; Christopher A Cottrell; Ivy Phung; Gabriel Ozorowski; Leigh M Sewall; Rebecca Nedellec; Catherine Nakao; Murillo Silva; Sara T Richey; Jonathan L Torre; Wen-Hsin Lee; Erik Georgeson; Michael Kubitz; Sam Hodges; Tina-Marie Mullen; Yumiko Adachi; Kimberly M Cirelli; Amitinder Kaur; Carolina Allers; Marissa Fahlberg; Brooke F Grasperge; Jason P Dufour; Faith Schiro; Pyone P Aye; Oleksandr Kalyuzhniy; Alessia Liguori; Diane G Carnathan; Guido Silvestri; Xiaoying Shen; David C Montefiori; Ronald S Veazey; Andrew B Ward; Lars Hangartner; Dennis R Burton; Darrell J Irvine; William R Schief; Shane Crotty
Journal:  Nature       Date:  2022-09-21       Impact factor: 69.504

6.  HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design.

Authors:  Kim-Marie A Dam; Christopher O Barnes; Harry B Gristick; Till Schoofs; Priyanthi N P Gnanapragasam; Michel C Nussenzweig; Pamela J Bjorkman
Journal:  Nat Commun       Date:  2022-10-17       Impact factor: 17.694
  6 in total

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