| Literature DB >> 3427140 |
A G Gristina1, C D Hobgood, L X Webb, Q N Myrvik.
Abstract
This study addresses the problem of antibiotic resistance in adhesive, biomaterial-centred infections. It is suggested that this anionic, extracapsular, polysaccharide slime produced by bacteria protects them from antibiotics and sequesters critical ions from the surface of biomaterials. Biofilm-enclosed bacteria on the surface of stainless steel substrata in a test chamber were challenged with incremental levels of tobramycin. In this setting, the minimum inhibitory concentration and minimum bactericidal level of tobramycin for Staphylococcus epidermis were well above normal.Entities:
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Year: 1987 PMID: 3427140 DOI: 10.1016/0142-9612(87)90077-9
Source DB: PubMed Journal: Biomaterials ISSN: 0142-9612 Impact factor: 12.479