Literature DB >> 34269889

B3Pdb: an archive of blood-brain barrier-penetrating peptides.

Vinod Kumar1,2, Sumeet Patiyal1, Rajesh Kumar1,2, Sukriti Sahai3, Dilraj Kaur1, Anjali Lathwal1, Gajendra P S Raghava4.   

Abstract

The blood-brain barrier poses major hurdles in the treatment of brain-related ailments. Over the past decade, interest in peptides-based therapeutics has thrived a lot because of their higher benefit to risk ratio. However, a complete knowledgebase providing a well-annotated picture of the peptide as a therapeutic molecule to cure brain-related ailments is lacking. We have built up a knowledgebase B3Pdb on blood-brain barrier (BBB)-penetrating peptides in the present study. The B3Pdb holds clinically relevant experimental information on 1225 BBB-penetrating peptides, including mode of delivery, animal model, in vitro/in vivo experiments, chemical modifications, length. Hoping that drug delivery systems can improve central nervous system disorder-related therapeutics. In this regard, B3Pdb is an important resource to support the rational design of therapeutics peptides for CNS-related disorders. The complete ready-to-use and updated database with a user-friendly web interface is available to the scientific community at https://webs.iiitd.edu.in/raghava/b3pdb/ .
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Entities:  

Keywords:  Blood–brain barrier; Blood–brain barrier-penetrating peptides; Database; Drug delivery; Neurological disorders

Mesh：

Substances：

Year:  2021        PMID： 34269889     DOI： 10.1007/s00429-021-02341-5

Source DB:  PubMed          Journal:  Brain Struct Funct        ISSN： 1863-2653            Impact factor:   3.270


  23 in total

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3.  A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA.

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Journal:  Biomaterials       Date:  2011-04-13       Impact factor: 12.479

4.  New Angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration.

Authors:  Christian Ché; Gaoqiang Yang; Carine Thiot; Marie-Claude Lacoste; Jean-Christophe Currie; Michel Demeule; Anthony Régina; Richard Béliveau; Jean-Paul Castaigne
Journal:  J Med Chem       Date:  2010-04-08       Impact factor: 7.446

5.  Cost of disorders of the brain in Europe 2010.

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Journal:  Eur Neuropsychopharmacol       Date:  2011-09-15       Impact factor: 4.600

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Journal:  Nat Biotechnol       Date:  2011-03-20       Impact factor: 54.908

7.  Impact of 3-D printed PLA- and chitosan-based scaffolds on human monocyte/macrophage responses: unraveling the effect of 3-D structures on inflammation.

Authors:  Catarina R Almeida; Tiziano Serra; Marta I Oliveira; Josep A Planell; Mário A Barbosa; Melba Navarro
Journal:  Acta Biomater       Date:  2013-11-05       Impact factor: 8.947

8.  Identification and design of peptides as a new drug delivery system for the brain.

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Journal:  J Pharmacol Exp Ther       Date:  2007-12-21       Impact factor: 4.030

9.  Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2.

Authors:  Michel Demeule; Jean-Christophe Currie; Yanick Bertrand; Christian Ché; Tran Nguyen; Anthony Régina; Reinhard Gabathuler; Jean-Paul Castaigne; Richard Béliveau
Journal:  J Neurochem       Date:  2008-05-19       Impact factor: 5.372

10.  Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1.

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  4 in total

1.  BBPpredict: A Web Service for Identifying Blood-Brain Barrier Penetrating Peptides.

Authors:  Xue Chen; Qianyue Zhang; Bowen Li; Chunying Lu; Shanshan Yang; Jinjin Long; Bifang He; Heng Chen; Jian Huang
Journal:  Front Genet       Date:  2022-05-17       Impact factor: 4.772

Review 2.  Brain physiome: A concept bridging in vitro 3D brain models and in silico models for predicting drug toxicity in the brain.

Authors:  Yoojin Seo; Seokyoung Bang; Jeongtae Son; Dongsup Kim; Yong Jeong; Pilnam Kim; Jihun Yang; Joon-Ho Eom; Nakwon Choi; Hong Nam Kim
Journal:  Bioact Mater       Date:  2021-11-12

Review 3.  Biological Membrane-Penetrating Peptides: Computational Prediction and Applications.

Authors:  Ewerton Cristhian Lima de Oliveira; Kauê Santana da Costa; Paulo Sérgio Taube; Anderson H Lima; Claudomiro de Souza de Sales Junior
Journal:  Front Cell Infect Microbiol       Date:  2022-03-25       Impact factor: 5.293

4.  Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases.

Authors:  Anja Holm; Stine N Hansen; Henrik Klitgaard; Sakari Kauppinen
Journal:  RNA Biol       Date:  2021-12-31       Impact factor: 4.766
  4 in total

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